>Aq_MTMR14_Myotubularin_MTMR14_AqueP029
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------ASLPYPGCEFFVHYRQN-KDSI-------
--------------GSVRYDWSMPSNDAVINVPSPLP-ESVGIDFTKYK--SWNIIQHTQ
NYIKLLLHYL----QY---EEGGILIHCVAGWDRTPLYISLLRLSLWADGHIHKSLCPIE
MLYLTLAYDWFMFGHKFEERLRKNE--------EVLYFCFDFLQHITS-----------D
DFS---------------------------------------------------------
----------------------------------------
>Dd_DDB_G0289807_Myotubularin_MTMR14_DdisP031
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SSTPYPGVEFFADFNRN-QHCG-------
--------------KDLFYSWDGIEDPAELNLHPDHQ--LPMIPWESYK--TWDLINLTQ
NYFKLLLKYVSD--DN---NPSGLLVHCISGWDRTPLFISLLRISLWADGEVHQSLKDWE
MLFLTVAYDWFLFSHQLCDRAGKGE--------DIFYFCFYFLDFISS-----------M
DFS---------------------------------------------------------
----------------------------------------
>Dm_EDTP_Myotubularin_MTMR14_DmelP029
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSLPYPGCEFFKKFRDN-NYMA-------
--------------RNLHYNWKQTFNDANINIPNMGPAADIDVAWSEYR--DWDLVAITQ
NYLRATLKYV----QE---ENSGLLIHCISGWDRTPLFVSLVRLSLWADGLIHQSLNAMQ
MAYFTLAYDWYLFGHQLPDRLKRGE--------DIMFFCFHVLKFITD-----------E
EFS---------------------------------------------------------
----------------------------------------
>Hs_MTMR14_Myotubularin_MTMR14_HsapP052
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSIPYPGCEFFKEYKDR-DYMA-------
--------------EGLIFNWKQDYVDAPLSIPDFLT-HSLNIDWSQYQ--CWDLVQQTQ
NYLKLLLSLV---NSD---DDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTE
ILYLTVAYDWFLFGHMLVDRLSKGE--------EIFFFCFNFLKHITS-----------E
EFS---------------------------------------------------------
----------------------------------------
>Mb_MTMR14_Myotubularin_MTMR14_MbreP022
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VALPYPGVEWFNSMREQ-HYNPFKIVRSL
PVLVPVSFLTIPCMACTFFNWSHPEVSVDLTIPKQAR-ALVDTDWSNYK--KWDLVTLTK
NYLKLMLAHIRTNKED---ADQGLLVHCISGWDRTPLFTSLLRLSLWADGLIHQSLSAEE
MLYLTVGYDWLLFGHLLPSRLNKGE--------EIFLFCFDVLQYLDS-----------D
EFS---------------------------------------------------------
----------------------------------------
>Nv_MTMR14_Myotubularin_MTMR14_NvecP028
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------CCVPYPGCEFFRDFKTK-GYSA-------
--------------DGLYFNWKQDYVDAQFTVPETLA-YRLGIEWHLYKASSWDLILLTQ
NYLLLLLNSI----MD---GEGGTLIHCISGWDRTPLFVSLLRLSLWADRKVHASLSASE
ILYLTIAYDWFLFGHDLPDRIQKGE--------EVFHFCFNFLKYIGS-----------D
TFS---------------------------------------------------------
----------------------------------------
>Sp_MTMR14_Myotubularin_MTMR14_SpurP032
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSLPYPGCEFFKDFRDN-GFNG-------
--------------INLFFDWSQDFVDADLSIPDRVA-TSTGIDWHMYR--QWDLVKITQ
NYLKLLLFLI----KD---GDSGVLVHCISGWDRTPLFISLLRLSLWADCKAHANLSAAE
ILYLTIAYDWLLYGHNLCDRLGKGE--------DVFFFCFNFLKHITS-----------D
DFS---------------------------------------------------------
----------------------------------------
>Aq_MTMR9_Myotubularin_MTMR9_AqueP034
--FSPENMTSLFTRYKC---------PPD------DWRVSDCNR-GYKLCSSHPEEVIIP
AKI---NDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLC--G-TTLKRCKEDIK
LLNSCLKIG---------------------------------------------------
----K-GRIFDIRTQQAAQHHMSK-GGGV-EFPSNYSQWRVEY-GS---MESITNIQSSY
LKLIDVCSD--------------------V---------NNSSWYGRLESSGWL--THVE
QLLRAVKHVV-HSVYQ---EGTSVVLHGTNGCDGTLQVSSLAILLMDPQART------IR
GFLQLIEREWLQGGHPFSLRHNIVSAA------PEKQKGPIFLLFLDAVWQIMRQYPLSF
EFNELLLHILFVHSYSSSYGTFLYDNPAERDRH--KLREKTESLWDYILLSPDVMSSIIN
PLYSKN--S----TLLVVSVHPCSIVFWKRLYLRTDLSPT
>Ce_mtm-9_Myotubularin_MTMR9_CeleP133
-GWSAFDLEQEFARLML---------STD------AFRISSVNE-NFAICPTYPEKLIVP
KGI---GDDYLKISATFREGGRFPVLSYFHKETKSPLVRCSQPLI--G-PTNRRCREDET
ILNSMITVN---------------------------------------------------
----R-GYIIDTRSKSSATAAKAK-GGGA-EPQGNYRQWRYIQ-CP---IPRQREIHDAL
TRMVDVCSE--------------------RK-V------TSDRWVSRVGQAGWL--SSVA
ASLEAAANVA-QCIYNERLEEVPVVIHGGDGLDSTLIASSLAQILLDADART------IR
GFESVIEREWICGGHPFSLRNNHCAYAEG--TVTGPFESPVFLVFLDAVHQMIAQYPMSF
EFDENFLIFLFEHAYASEFGSFLGNCEKEKKDN--GIRKKTVSLWSHVHH-PENMKQFVN
VCYDPT--P----GVIWPSIAPQCIKIWDRLFFRWQRPD-
>Dm_CG5026_Myotubularin_MTMR9_DmelP033
---------GGALQSPQ---------ASC------EWRITNVNR-DFSVCATYGATLIVP
KAI---TDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLS--I-QGIKRCRADEA
ILNLVLGRS---------------------------------------------------
---RK-GFIVDTWGKG---------KSNT-ETDLHYSQWKKVN-RSIGNVSSPASILDSF
ARLIEACND--------------------LG-C------STDKWLSRLENSGWL--SLVL
NSLNASCVVA-QCLDQ---EGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRT------VR
GLQALIEREWIQAGHPFASRHRYSCYTPN--QTRNKTSGATFVLFLDCIYQLYTQFPCSF
EFSTQLLILLFEHSHFSQYGTFLCDSERERNEL--NVHTRTTSLWSYLNR-PDVLQTFLN
PLYEPN--A----NVIWPSVAPISLELWSDLYLRWVIDQ-
>Hs_MTMR9_Myotubularin_MTMR9_HsapP060
-GWHSFLPEQEFELYSS---------ATS------EWRLSYVNK-EFAVCPSYPPIVTVP
KSI---DDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLT--G-TNGRRCKEDEK
LINATLRAG---------------------------------------------------
---KR-GYIIDTRSLNVAQQTRAK-GGGF-EQEAHYPQWRRIH-KS---IERYHILQESL
IKLVEACND--------------------QT-H------NMDRWLSKLEASNWL--THIK
EILTTACLAA-QCIDR---EGASILIHGTEGTDSTLQVTSLAQIILEPRSRT------IR
GFEALIEREWLQAGHPFQQRCAQSAYC----NTKQKWEAPVFLLFLDCVWQILRQFPCSF
EFNENFLIMLFEHAYASQFGTFLGNNESERCKL--KLQQKTMSLWSWVNQ-PSELSKFTN
PLFEAN--N----LVIWPSVAPQSLPLWEGIFLRWNRSS-
>Mb_MTMR9_Myotubularin_MTMR9_MbreP025
------------------------------------------------------------
---------FSRSVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLA--G-SSGKRKYEDEQ
MLRMVLSTAD--------------------------------------------------
--VKQ-GLILDTRTSSVASTHRSK-GGGL-EVIDKYYGWSRKM-LD---IAAWPILADSL
SKLLEACQD--------------------PS-L------DASKFLEKLNASNWL--STVR
DALSAALQAV-TCLEH---EQQPVVVHGSHGTDITCIVVALAQLYMDPYFRT------LE
GFCKLVEKEWLHAGHPFASRWSPLTRH------NKTERAPVFLLFLDCVYQSYFQFCAAF
EFNESFLMELYMQSYSCVFGTFVGDCEAMRAAE--QLDKKTRCFWRHALS-PEQRPRFAN
PLYDAAVNK----GTICPSPRPQAIVLWRNLYCWRSYWEL
>Nv_MTMR9-2_Myotubularin_MTMR9_NvecP033
-GWDMFSNDLDFAKVCS---------STQ------SWRISHVNI-NYEVCASYPTSVIVP
LGV---SDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLC--GSMSNKRCKEDEK
LVNSALGSM---------------------------------------------------
---KK-GMIVDTRSTPAVMNSRSK-GGGL-EPESNYPQWKRSN-HN---IEKHTVLIDSV
CKLMEACFD--------------------QN-L------SMNAYLSRLESCGWM--DQIQ
AVLGTACYVA-HCLHT---DGIPVLVHDGAGLDATLQVTSLSQVILDPDCRT------VR
GFQSLVDREWIRGGHPFSNRCTRVGFS----STKYKGQGPVFLLFLDCVWQIYQQFPCSF
EFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTV--KLKEKTISLWSYLNQ-DEILEDMLN
PMYERN--E----SVLWPSVAPQSLVLWPGLYLKWQKQQ-
>Nv_MTMR9-1_Myotubularin_MTMR9_NvecP034
-----------------------------------------INL-FFQVCASYPTSVIVP
LGV---SDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLC--GSMSNKRCKEDEK
LVNSALGSM---------------------------------------------------
---KK-GMIVDTRSTPAVMNSRSK-GLKI-A-------------LT---TPNVLSFKDCH
PLLFLWETP--------------------H---------------LRLSAPHHA--SVVQ
FLI--------------------------------VVVVLFAIVPLEVYLGH----CLGS
RFQSLVDREWIRGGHPFSNRCTRVGFS----STKYKGQGPVFLLFLDCVWQIYQQFPCSF
EFHDSFLICLFEHAYYSQFVAPLTSCASQQV-----------------------------
--------------------------LWPGLYLKW-----
>Sp_MTMR9_Myotubularin_MTMR9_SpurP038
-GWHAFLPENEFARLAS-----------D------DWRISYVNK-NFQVCPSYPPAVIVP
KSI---DDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLT--G-TNTKRCKDDER
LLNAALSVG---------------------------------------------------
---KR-GYIIDTRSMNGAMAARTK-GGGF-ETEVNYPQWRRVN-KP---LDKPSILQESL
CKLLEACMD--------------------TG-C------SADKWISRLTNCGWL--HHVK
ETLTTACLVA-QCVDR---ENSAVLVHGSEGLDASLQVTSLAQVILDADCRT------VR
GFEALIEREWIQAGHPFLSRCSKSVFS----QNKNKYAGPVYLLFLDCVWQIFQQFPCSF
EFSEKFLIMLFENAYASRFGTFLCNNENERKMA--RVSEKTVSLWTYVNR-PQILQTFFN
PLYQPN--Q----QVIWPSVAPQSLALWSSLYMRWTMSD-
>Aq_MTMR3_Myotubularin_MTMR3_AqueP030
-SLSTELLTSEYSRLGF------------NK--PGTWRITDANA-KYELCSSYPKVFVVP
QSV---TDSDLLQVSKFRSLSRLPAVVWRHKGNGCVLARASQPLV--G-FLGWRCQEDEQ
FLKALSKSCHPHAPPMEVMS---HGE-------KIT---------------------NGV
GQTPS-LLVVDLRSYTAAFGNRAK-GGGC-EHQDYYSNCEIVY-KG---LPNIHSVRTSF
GSLRNLLSG--------------------N---------EQIRFFSQLEGTHWL--QNIS
QLLQTAVEVS-NTLHH---HSRPVLIHCSDGWDRTTQITSLAQLLLDPYYRS------LE
GFRVLVEREWLSFGHKFSDRCGFGP----D-----GEQSPVFLQWLDCLYQISNQFPTSF
EFNSIFLVKLAQHCYSQLYGTFLGNCEQERERE--LVRLQTLSLWDCL---EK-EREITN
AIYKENGDE----VVLCPNYQVRSLKLWRELFLHLPLTRY
>Ce_mtm-3_Myotubularin_MTMR3_CeleP130
-SVAQEITHIDFNRLGM----------------SEHFQISSVNE-NFEVCPTYPEKIIVP
KGI---TDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRSSQPQV--G-ILSWRNPTDEK
IIEEAVKASRIEGE----------------------------------------------
-EKKQ-FIIMDARGYTSAFANRAR-SGGF-ENTEYYQQAKLEF-LG---LPNIHAVRGSF
NNVRTMLHN--------------------L--G------PNEQLLTSLQTTGWL--LNLS
NLLVNAANCA-DHLSK----GHSVLVHCSDGWDRTTQVTTLAKIMLDEYYRT------VK
GFEELIRRDWIAFGHKLYDRQLVAF----GNWGTSDERSPVFLQFLEAVRHLQREQPTLF
QFTHAYLIKLAKHAYSGLFGSFLFNSHKERREAMEKCKGTLVDIWRFI---GPHNEEYVN
QSFDEHYTG----AVKPVNVSVINLRVWHEVFADEEEHY-
>Dm_CG3632_Myotubularin_MTMR3_DmelP030
-VRYESDFKNEVARLGF------------DL--KGSWRISTANA-DFKLCPSYPPKLLVP
CCI---TDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEV--G-WLGWRNTRDEQ
LLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTL
DEIKK-ILIVDARSYTSAVTNRAR-GGGC-ECIEYYPCAEIEF-MN---LGNIHAIRKSF
HAVRQLCAS--------------------S--P------DDPNWYGQLEKTMWM--QHLS
GLLGATMTVV-HTIEK---NGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT------VE
GFRVLVEREWLNFGHKFADRSGNGP----N-SDEVNERCPVFLQWLDLVHQIHRQYPCSF
EFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN--SVFDRTFSVWPFL---A--ETMYRN
PLYKHET-E----KVLWPAHSVRFLYFWSDVYLGSLGNK-
>Hs_MTMR3_Myotubularin_MTMR3_HsapP053
-EHVTSRFKNEVERMGF------------DM--NNAWRISNINE-KYKLCGSYPQELIVP
AWI---TDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV--S-WWGWRNADDEH
LVQSVAKACASDSRS--SGSKLSTRNTSRD-F-PNGGDLSDV--EFDSSLSNASGAESLA
IQPQK-LLILDARSYAAAVANRAK-GGGC-ECPEYYPNCEVVF-MG---MANIHSIRRSF
QSLRLLCTQ--------------------M--P------DPGNWLSALESTKWL--HHLS
VLLKSALLVV-HAVDQ---DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRT------IE
GFQVLVEMEWLDFGHKFADRCGHGE----N-SDDLNERCPVFLQWLDCVHQLQRQFPCSF
EFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEK--HTQERTCSVWSLL---RAGNKAFKN
LLYSSQS-E----AVLYPVCHVRNLMLWSAVYLPCPSPT-
>Hs_MTMR4_Myotubularin_MTMR3_HsapP054
-EHIRCRQEAELARMGF------------DL--QNVWRVSHINS-NYKLCPSYPQKLLVP
VWI---TDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEI--S-WWGWRNADDEY
LVTSIAKACALDPGTRATGGSLSTGN-------NDTSEACDA--DFDSSLTACSGVESTA
-APQK-LLILDARSYTAAVANRAK-GGGC-ECEEYYPNCEVVF-MG---MANIHAIRNSF
QYLRAVCSQ--------------------M--P------DPSNWLSALESTKWL--QHLS
VMLKAAVLVA-NTVDR---EGRPVLVHCSDGWDRTPQIVALAKILLDPYYRT------LE
GFQVLVESDWLDFGHKFGDRCGHQE----N-VEDQNEQCPVFLQWLDSVHQLLKQFPCLF
EFNEAFLVKLVQHTYSCLYGTFLANNPCEREKR--NIYKRTCSVWALL---RAGNKNFHN
FLYTPSS-D----MVLHPVCHVRALHLWTAVYLPASSPC-
>Nv_MTMR3_Myotubularin_MTMR3_NvecP029
-SATPYSFLEEVHRMGF------------ETGVDSPWRISDANS-SFEVCRTYPRLHVIP
SSI---SDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQV--G-WLGWRSAEDEL
LLQAIGQACTSDRYPSVA--KLLNGITVNG-I-NKKHDMGDV--LNG--PADMSEDGPIA
RNPKQ-VLIVDARSYTAAYANRGK-GGGF-EYTEYYPNCEVMF-MN---LANIHGIRRSF
HSLRALCSG--------------------S--Y------DVPNWWSLIEKTNWL--HHIS
MLIKSAVTIV-HAVHT---DGRPVVVHCSDGWDRTTQIVALAELLLDPFYRT------IE
GFKILIDREWLQFGHRFADRCGHGS----D-I-DENERCPVFLQWLDCVHQLQKQFPSSF
EFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTD--AIKARTLSVWSYI---LPRKKDFRN
LLYAGGG-D----QV-------------------------
>Sp_MTMR3_Myotubularin_MTMR3_SpurP033
-KVTHCKFGTEIDRQGF------------DL--KKAWRIFDN-S-DFKYCTTYPTQHIVP
KEI---EDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAV--G-WLGWRSEEDER
FMSAILDACAMDDPRKNKKSCHSNGYVKSEQY-RVTDDQ----------DEMRRGEYERS
NQSKT-ILIIDARSYAAAFANRAK-GGGC-EYPEYYTCCDIEF-MG---LANIHSVRKSF
NTVHALCSN--------------------NS-L------DQTTWLSNLEATKWL--QNLS
MLLKAAIKVV-TAVDQ---EARPVIVHCSDGWDRTPQIVALAEIMLDPYYRT------MQ
GFQALVEREWLDFGHKFADRCGHRP----G-QDDANERCPVFLQWLDCIHQLLRQYPTAF
EFNETFLVKLVQHTYSCLFGTFLCNSLKARLKN--SIKERTCSVWSLI---VVEGNKYRN
FLYDPKT-Y----KVLYPTCNIRELDLWIAVYLSETSHS-
>Aq_MTMR1-3_Myotubularin_MTMR1_AqueP024
-DWNVEAQLH-TDMARM---------MSD------NWKESPLNC-LYTLCPTYPPVVYIP
KVV----------------RGRVPSLVWMDKVNGTFLLRSAQPLP--G-LSDKHSTEDET
LLKYAITCYE--------------------------------------------------
--GEG-LMIFDARSSSAATGNRIM-GKGT-EDVSRYYRCKLTH-LD---IPNIHAVRESY
EGLKQLALS--------------------T---------SSTRWYSSLESTQWI--EYIS
LILKGSYLIA-RLIKI---HSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRT------ID
GFLTLIAKEWLSYGHKFKERLGHPL--------NPNERSPIFLQFLDCVHQLMNQYPHAF
QFNLSFLLTIAEHLNTGWFGTFLFNCHKERIEN--DVFVSTVPITAHF---NAMRDVYIN
LNYRET-K-----EIIMPTWTIRRLRLWEEYFLAWDGTS-
>Aq_MTMR1-4_Myotubularin_MTMR1_AqueP025
-GWEVYDPEAELKRMGV---------GND----GVPWRICHLNK-NYELCDTYTSTFSVP
LNC---SDEMVQGVAQFRSKGRIPVLSWLHPVTQASITRCSQPLV--G-TMNRRSKEDEQ
YMQEILKAND--------------------------------------------------
-KSNK-LYILDARPKINAMTNVAM-GGGY-EHEDCYVNMDFSF-LD---IGNIHVMRESL
KKLREICYP--------------------D--V------DDQRWFSNLESSHWL--DHIK
AILCGAVKVV-ECVET---HKSSVVVHCTDGWDRTAQITSLSMLMMDSYFRT------IK
GFEVLVEKEWLGCGHKFSQRTGHGD-----KNHSDDQRSPIFLQFIDCVWQLMEQFPTAF
EFNEHFLITILDHLYSCLFGTFLFNCERLRVEA--GVKDKTVSLWSFV---NSQIDVYKN
PLYAELMN----NKVLFPRTSIRILKLWTGYYMRWNPRM-
>Aq_MTMR1-1_Myotubularin_MTMR1_AqueP022
-GWEVYDPEAELKRMGV---------GND----GVPWRICHLNK-NYELCDTYTSTFSVP
LNC---SDEMVQGVAQFRSKGRIPVIQF--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------
>Aq_MTMR1-2_Myotubularin_MTMR1_AqueP023
KLPNFFHFNAEMERTGI---------LNAKIGNTSLWRITTITKTNPDLCPSYPEKLVVL
LCI---PDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSERG-LQSSKLPVDEA
ILQAIRGCNA--------------------------------------------------
-NSRL--FVFTEKSDTSGFQDPNKLTKEA-ARSYYYHNCHFIYSVN---PPTYKSVRHSF
NKLQAMLQS--------------------N--I------SDDEYMVTLDGTKWL--SRVG
DLLDTAHKVV-EALTV---ESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRT------MD
GFQVLIQKEWLWFGHPFQSRHSRSRAAVGGASSKIKEDGPVFLQWIDCVWQITRQCPFAF
EFNENLLICFMI---------------PDHYHQ--SIYTNTISFWTWVSMVNSSNNIFFN
NYYDPDFHK----GAIYPKFYQTCLEIWRTHYDRHKLRQE
>Ce_mtm-1_Myotubularin_MTMR1_CeleP129
-GWKIYSAEKEYERLGI---------PNS-----RLWKEVDINK-DYKFSETYPRTFVIP
TVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMT--G-ISGKRSAEDER
HLTNIMNANA--------------------------------------------------
-NCRE-LLILDARPAVNAKLNKAK-GGGY-E--ENYVNAPLTF-LN---IHNIHVVRDSL
KRLLAALIP--------------------R--V------DEKGYYKALDESKWL--NHVQ
SILEGAVKAV-FNVDT---EKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRT------IE
GFIVLIEKEWCSFGHKFGERIGHGD-----DNYSDGERSPVFVQFCDCLWQIMRQFPWAF
EFTQELLICMLDELYACRYGTFLYNSEKIRLKD-KKCDETTISFWSYV---LENKKKFRN
PMFKHGKS----NKVINVNPSLCGLHVWIDYYARSNPYV-
>Dm_mtm_Myotubularin_MTMR1_DmelP027
-GWAVYEPLAELRRLGV---------PND------MWRATKLNE-SYAICDSYPAVWAVP
KAA---SDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLV--G-VSGKRNSDDEA
YLSFIMEANA--------------------------------------------------
-QSDK-LTIMDARPSANAIANKAK-GGGY-ESEDAYKNVEINF-LD---IHNIHVMRESL
RKVKEACFP--------------------T--T------DDSKWQTAIDNTLWL--KHIR
CILAGAVRIV-DKVET---MSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRT------VR
GFEVLIEKEWLSFGHKFQQRIGHGD-----NKHSDADRSPVFLQFIDSVWQVSQQFNNAF
EFNEHFLITIVDHLYSCRFGTFLCNTEAERVAE--DLKHKTTSLWTHI---NSSLDQYLN
PLFPSFTHG--AELVLRPIASVRSVRLWKGLYCRWNPGL-
>Hs_MTMR1_Myotubularin_MTMR1_HsapP047
-GWKVYDPVSEYKRQGL---------PNE------SWKISKINS-NYEFCDTYPAIIVVP
TSV---KDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLV--G-PNDKRCKEDEK
YLQTIMDANA--------------------------------------------------
-QSHK-LIIFDARQNSVADTNKTK-GGGY-ESESAYPNAELVF-LE---IHNIHVMRESL
RKLKEIVYP--------------------S--I------DEARWLSNVDGTHWL--EYIR
MLLAGAVRIA-DKIES---GKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRT------IK
GFETLVEKEWISFGHRFALRVGHGN-----DNHADADRSPIFLQFVDCVWQMTRQFPSAF
EFNELFLITILDHLYSCLFGTFLCNCEQQRFKE--DVYTKTISLWSYI---NSQLDEFSN
PFFVNYE-----NHVLYPVASLSHLELWVNYYVRWNPRM-
>Hs_MTMR2_Myotubularin_MTMR1_HsapP048
-GWKLYDPLLEYRRQGI---------PNE------SWRITKINE-RYELCDTYPALLVVP
ANI---PDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMV--G-VSGKRSKEDEK
YLQAIMDSNA--------------------------------------------------
-QSHK-IFIFDARPSVNAVANKAK-GGGY-ESEDAYQNAELVF-LD---IHNIHVMRESL
RKLKEIVYP--------------------N--I------EETHWLSNLESTHWL--EHIK
LILAGALRIA-DKVES---GKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRT------IR
GFEVLVEKEWLSFGHRFQLRVGHGD-----KNHADADRSPVFLQFIDCVWQMTRQFPTAF
EFNEYFLITILDHLYSCLFGTFLCNSEQQRGKE--NLPKRTVSLWSYI---NSQLEDFTN
PLYGSYS-----NHVLYPVASMRHLELWVGYYIRWNPRM-
>Hs_MTM1_Myotubularin_MTMR1_HsapP046
-GWTVYNPVEEYRRQGL---------PNH------HWRITFINK-CYELCDTYPALLVVP
YRA---SDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLV--G-MSGKRNKDDEK
YLDVIRETNK--------------------------------------------------
-QISK-LTIYDARPSVNAVANKAT-GGGY-ESDDAYHNAELFF-LD---IHNIHVMRESL
KKVKDIVYP--------------------N--V------EESHWLSSLESTHWL--EHIK
LVLTGAIQVA-DKVSS---GKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRS------IE
GFEILVQKEWISFGHKFASRIGHGD-----KNHTDADRSPIFLQFIDCVWQMSKQFPTAF
EFNEQFLIIILDHLYSCRFGTFLFNCESARERQ--KVTERTVSLWSLI---NSNKEKFKN
PFYTKEI-----NRVLYPVASMRHLELWVNYYIRWNPRI-
>Mb_MTMR1_Myotubularin_MTMR1_MbreP021
-DWSRYDPMAEMRRQGLVFEEDVFSGSLS------AWMKSDLNR-DYELCPTYPPILFLP
RMV---SESVIRGSAAFRSKQRLPVLTWYSDRGGRRR-----------------------
-------SIV--------------------------------------------------
--RDQ-IAVFDARSMIAAGGNQIM-GKGS-ENSAFYVGAQVFF-ME---IGNIHTMRASH
DKLLELCIG--------------------V---------SDVQWYSQLENTGWL--SHIK
AVLSAARAIA-RKVEN---LAITALVHCSDGWDRTSQLVSLAQIMLDPYFRT------ID
GLIVVIEKDWLAFGHKFDERHGGAD--------SVTERSPIFLQFLDCLYQMTVQHPTAF
EYNSRLLVFLADYSRAGWFGNFQCNSHRERRAR--RLSQTTTSIWSAV---EADRPRFTS
SQYAPGGS-----DVIMPTCSLKRIELWSDYFLRYDASV-
>Nv_MTMR1-2_Myotubularin_MTMR1_NvecP025
-GWDVYDAEKEFERLGL---------PTD------CWYVTRINE-KYELSDTYPAVVGVP
SSV---SDEDIKKVAVFRSRNRLPVLCWLHPTNNASITRASQPNR--G-L-LARNKDDEK
YFQAILEANP--------------------------------------------------
-QCHK-LLIFDARPRINAVANQAK-GGGY-ETEENYQNTEVIF-LD---IANIHVMRESL
RKLKDICFP--------------------N--I------DDTHWLTNLENTKWL--DHIK
MIMAGAVRIA-DAVDR---CRTSVVVHCSDGWDRTPQLTALAMLLMDPYYRT------II
GFEVLIEKEWLSFGHKFNQRYGHGD-----KNHADDQRSPVFLQFIDCVWQVTRQFPCAF
EFNETFLITILDHLYSCMFGTFLYNSESQREKE--DVKTRTTSLWSYI---NTSMMEFKN
PLYAPYLH----QHVLFPVPSLRRLELWTRYYIRWNPRM-
>Nv_MTMR1-1_Myotubularin_MTMR1_NvecP024
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------IFGMSGRPLCTFFCVQ---GKGTEDTLNRYQGCSLVF-LD---IPNIHAVRDSL
DRLQAVCES--------------------S---------SQKKWLSHLESTQWL--AYIA
AILKGATTIA-RFVDK---G-VSTLVHCSDGWDRTSQLTLLAQLLLDPYYRT------FT
GFQVLIEKEWISFGHRFRDRLGHPT--------CPSQRSPIFLQFLDCVWQVHKQFPSAF
QFTANYLLKLADHVNSQWFGNFLYNNVQERHHA--FITRTTVSLWSHL---NAVKDNYTN
SIYQPT-------ETLVPVSSLRRLQLWSDYFLRYD----
>Nv_MTMR1-3_Myotubularin_MTMR1_NvecP026
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RF------IS
LFQVLIEKEWISFGHRFRDRLGHPT--------CPSQRSPIFLQFLDCVWQVHKQFPSAF
QFTANYLLKLADHVNSQWFGNFLYNNVQERHHA--FITRTTVSLWSHL---NAVKDNYTN
SIY-------------------------------------
>Sp_MTMR1_Myotubularin_MTMR1_SpurP029
-GWAVFDPVAEYKRQGL---------PTE------SWRISRINE-NFTFCDTYPAVLAIP
AAA---DDELLRQVAAFRSRNRLPIMSWLHPQSQATITRCSQPLV--G-VGGKRSKEDEK
YVQMILDANA--------------------------------------------------
-QSHK-LVIMDARPTVNAVANKAK-GGGY-ENEDTYQNAEICF-LD---IHNIHVMRESL
RKLKDICFP--------------------S--I------DEHHWLANLEATHWL--EHVK
MVLAGAVRIA-ERVEG---QKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRT------IR
GFEVLIEKEWLACGHKMAQRHGHGD-----KNYTDADRSPIFQQFIDCVWQVTRQFPNAF
EFNEHFLITILDHLYSCLFGTFLFNCERERVKE--QVKTKTVSLWSYI---NSSMEEFIN
PMYASYMH----QHVLFPVASMRRIELWTSYYIRWNPRM-
>Aq_MTMR6_Myotubularin_MTMR6_AqueP033
-GWNLYDSVVEYGRMGV---------PNE------HWVCTELNK-DYELCETYSNTLFVP
AKA---EKSVVLGSAKFRSKGRLPVLSYYCQAKNSALCRSSQPLT--Y-I-TRRSQEDEA
MIQAIIDANP--------------------------------------------------
-NSSS-LHLLDSRPKINAVANKAAHKGGY-ETTDNYPNIVYQF-NN---IQNIHVMRESL
QKLLEALHS--------------------P--A------GVSSVLQGLDASSWL--RHIH
LVLEAGAFIA-KALYT---EGINVLVHCSDGWDRTAQTCSLASLMIDKYYRT------IH
GFMILIEKEWLSFGHKFTIRSGHIN-------SDSKEVSPIFTQFLDAVWQIMVQFPKSF
EFNELFLLTIHDHLFSCQFGTFLGNNERDRKIN--KFSEKTYSLWGYI---WSRLDDFTN
PLFDNDTE-----NYIMPKTEVSILSLWRGLYCCYETG--
>Ce_mtm-6_Myotubularin_MTMR6_CeleP132
-GWRRLDWNSEMTRQGI---------TKS------QWTESNINE-GYTICDTYPNKLWFP
TAA---STSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLT--G-F-SARCVEDEK
LMELVGKANT--------------------------------------------------
-NSDN-LFLVDTRPRVNAMVNKVQ-GKGF-EDERNYSNMRFHF-FD---IENIHVMRASQ
ARLLDAVTK--------------------C--R------DVTEYWKTLEASGWL--KHVR
SVVECSLFLA-ESISR----GTSCVVHCSDGWDRTSQVVALCQLLLDPYYRT------IH
GFQVLIEKDWLGFGHKFDDRCGHVGA---LNDEAGKEVSPIFTQWLDCIWQIMQQKPRAF
QFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDL--NLSKRTKSLWTWM---DARHDDYMN
PFYSPTAHV----ALLDLDTRAARFTVWTAMYNRFDNGL-
>Dm_CG3530_Myotubularin_MTMR6_DmelP032
-GWDYFKLEAEFKHMLV---------PNE------AWTLCSMNE-KYELCDTYPRQIYVP
KEA---TTLMLISSSRFRSKGRLPVLTYLHN-NKASICRCSQPLS--G-F-SARCLEDEQ
MLEAIRKTNS--------------------------------------------------
-NTDY-MYVVDTRPRINAMANRAA-GKGY-ENEAFYENIKFHF-LG---IENIHVQRASL
QKVLEACEQ--------------------KS-P------TMSAFINALESSGWL--KHIR
SILDTSSFIA-NAVDK----GVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRT------IK
GFQALIEKDWLAFGHKFSERCGHIQ-------TDAREVSPIFTQFLDCTWQLMSQRSEAF
EFNERFLLILHDHVHSCQFGTFVGNCEKDRLDL--KLAERTFSLWGYM---ANHLNEYIN
PLYKPNVD-----EAIKANLAPQCIKFWRGMYSRFESGI-
>Hs_MTMR8_Myotubularin_MTMR6_HsapP059
-GWKLIDPISDFGRMGI---------PNR------NWTITDANR-NYEICSTYPPEIVVP
KSV---TLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLS--G-F-YTRCVDDEL
LLEAISQTNP--------------------------------------------------
-GSQF-MYVVDTRPKLNAMANRAA-GKGY-ENEDNYANIRFRF-MG---IENIHVMRSSL
QKLLEVCEL--------------------KT-P------TMSEFLSGLESSGWL--RHIK
AIMDAGIFIT-KAVKV---EKASVLVHCSDGWDRTAQVCSVASILLDPFYRT------FK
GLMILIEKEWISMGHKFSQRCGHLD-------GDSKEVSPIFTQFLDCIWQLMEQFPCAF
EFNENFLLEIHDHVFSCQFGNFLGNCQKDREDL--RVYEKTHSVWPFL---VQRKPDFRN
PLYKGFTMY----GVLNPSTVPYNIQFWCGMYNRFDKGL-
>Hs_MTMR7_Myotubularin_MTMR6_HsapP058
-GWVLIDLSEEYTRMGL---------PNH------YWQLSDVNR-DYRVCDSYPTELYVP
KSA---TAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLS--G-F-SARCLEDEQ
MLQAIRKANP--------------------------------------------------
-GSDF-VYVVDTRPKLNAMANRAA-GKGY-ENEDNYSNIKFQF-IG---IENIHVMRNSL
QKMLEVCEL--------------------KS-P------SMSDFLWGLENSGWL--RHIK
AIMDAGIFIA-KAVSE---EGASVLVHCSDGWDRTAQVCSVASLLLDPHYRT------LK
GFMVLIEKDWISFGHKFNHRYGNLD-------GDPKEISPVIDQFIECVWQLMEQFPCAF
EFNERFLIHIQHHIYSCQFGNFLCNSQKERREL--KIQERTYSLWAHL---WKNRADYLN
PLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGM-
>Hs_MTMR6_Myotubularin_MTMR6_HsapP057
-GWQLIDLAEEYKRMGV---------PNS------HWQLSDANR-DYKICETYPRELYVP
RIA---SKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLS--G-F-SARCLEDEH
LLQAISKANP--------------------------------------------------
-VNRY-MYVMDTRPKLNAMANRAA-GKGY-ENEDNYSNIRFQF-VG---IENIHVMRSSL
QKLLEVNGT--------------------KG-L------SVNDFYSGLESSGWL--RHIK
AVMDAAIFLA-KAITV---ENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT------IK
GFMVLIEKDWISFGHKFSERCGQLD-------GDPKEVSPVFTQFLECVWHLTEQFPQAF
EFSEAFLLQIHEHIHSCQFGNFLGNCQKEREEL--KLKEKTYSLWPFL---LEDQKKYLN
PLYSSESHR---FTVLEPNTVSFNFKFWRNMYHQFDRTL-
>Mb_MTMR6_Myotubularin_MTMR6_MbreP023
-GWALYSPMAEYGRMGV---------PNP------QWQQVDYNN-TYNLCPTYGRTLYLP
SSV---TMEQAFASAKFRSKQRLPVLSYLFQRNQAAICRCAQPLT--G-VQAKRSEDDEA
LLEFIRLCNP--------------------------------------------------
-HSELPLIIVDTRPRMNAMANKAA-GKGF-ENMEGYTNCRLEF-HG---IENIHTMRGSL
NALVKASKR--------------------N--S------PCHDHQIGIQECAWL--KHIQ
AVLKTTMVIT-RYIQD----GHSVLVHCSDGWDRTAQTCSLAGLMLDPYYRT------IE
GYIVLIEKEWLSFGHKFLDRNGFLK-------GSGREVSPIFLQLLECTWCLQRQFPLAF
EFNESFLIAMHDCLHSCKFGTFLGNCEQARRDA--KLHERTQSAWSYL---YSRKSEFIN
PFYDASQDP--EGGVLNPSLAPQHFELWSAMYCRWESAS-
>Nv_MTMR6_Myotubularin_MTMR6_NvecP031
-GWALFDIKSDYTRMGV---------PSD------LWTATQLNK-DYELCDTYPNILYVP
KSA---TKEVLVGSSRFRSRGRLPVLSFYHKSTQAAVCRCSQPLG--G-F-KGRCPEDEQ
MIQALLNSNP--------------------------------------------------
-NSKF-IYIVDTRPRLNALANRAA-GKGY-ESEDFYENVKFQF-VG---IENIHVMRQSL
FKMLEVVGE--------------------SPKT------PAGAFYSGLEASNWL--KHIK
NILDTSVFIA-KAVAM---EKASVLVHCSDGWDRTAQTCSLASIILDPYYRT------IH
GFQVLIEKEWLSFGHKFTDRCGLLQ-------SDQKEFSPVFLQFLESIWQLLQQFPFSF
QFNERFLLTLHDHVYSCQFGTFLGNCQKERRDL--GLPKRTYSLWGYM---WQNISDYAN
PLYREVTQ----DDALWPDTSPQAIRFWRAMYNRYDNEV-
>Sp_MTMR6_Myotubularin_MTMR6_SpurP036
-GWDQFDLQAEYARMGI---------PNA------HWCSTAINK-NYEICDTYSRTLYVP
THA---SPPVLVGSSRFRSRGRLPVLSYLHQENNKRLRGRVTFD----------------
------------------------------------------------------------
--------------------------------------------------VNQNLALEIL
RPLSDNFSL--------------------KN-P------SMEAFLSGLESSQWM--KHIK
AVLDTSLFIA-KAIAD---EGLSVLVHCSDGWDRTAQTCSLASIILDPYYRT------IQ
GFQVLIEKEWLAFGHKFLHRCGLLA-------YDPREVSPVFTQFIECTWQLCQQFPCAF
QFNERFLLELHDHVFSSQFGNFLGNCERERQDK--KLSQKTFSLWQYM---QARMSDYIN
PLYKANHPSA--NGILKPNFSPQMLKFWRGMYNRYENGV-