45 520 Aq_MTMR14_Myotubularin_MTMR14_AqueP029 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASLPYPGCEFFVHYRQN-KDSI---------------------GSVRYDWSMPSNDAVINVPSPLP-ESVGIDFTKYK--SWNIIQHTQNYIKLLLHYL----QY---EEGGILIHCVAGWDRTPLYISLLRLSLWADGHIHKSLCPIEMLYLTLAYDWFMFGHKFEERLRKNE--------EVLYFCFDFLQHITS-----------DDFS------------------------------------------------------------------------------------------------- Dd_DDB_G0289807_Myotubularin_MTMR14_DdisP031 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTPYPGVEFFADFNRN-QHCG---------------------KDLFYSWDGIEDPAELNLHPDHQ--LPMIPWESYK--TWDLINLTQNYFKLLLKYVSD--DN---NPSGLLVHCISGWDRTPLFISLLRISLWADGEVHQSLKDWEMLFLTVAYDWFLFSHQLCDRAGKGE--------DIFYFCFYFLDFISS-----------MDFS------------------------------------------------------------------------------------------------- Dm_EDTP_Myotubularin_MTMR14_DmelP029 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSLPYPGCEFFKKFRDN-NYMA---------------------RNLHYNWKQTFNDANINIPNMGPAADIDVAWSEYR--DWDLVAITQNYLRATLKYV----QE---ENSGLLIHCISGWDRTPLFVSLVRLSLWADGLIHQSLNAMQMAYFTLAYDWYLFGHQLPDRLKRGE--------DIMFFCFHVLKFITD-----------EEFS------------------------------------------------------------------------------------------------- Hs_MTMR14_Myotubularin_MTMR14_HsapP052 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSIPYPGCEFFKEYKDR-DYMA---------------------EGLIFNWKQDYVDAPLSIPDFLT-HSLNIDWSQYQ--CWDLVQQTQNYLKLLLSLV---NSD---DDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGE--------EIFFFCFNFLKHITS-----------EEFS------------------------------------------------------------------------------------------------- Mb_MTMR14_Myotubularin_MTMR14_MbreP022 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VALPYPGVEWFNSMREQ-HYNPFKIVRSLPVLVPVSFLTIPCMACTFFNWSHPEVSVDLTIPKQAR-ALVDTDWSNYK--KWDLVTLTKNYLKLMLAHIRTNKED---ADQGLLVHCISGWDRTPLFTSLLRLSLWADGLIHQSLSAEEMLYLTVGYDWLLFGHLLPSRLNKGE--------EIFLFCFDVLQYLDS-----------DEFS------------------------------------------------------------------------------------------------- Nv_MTMR14_Myotubularin_MTMR14_NvecP028 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CCVPYPGCEFFRDFKTK-GYSA---------------------DGLYFNWKQDYVDAQFTVPETLA-YRLGIEWHLYKASSWDLILLTQNYLLLLLNSI----MD---GEGGTLIHCISGWDRTPLFVSLLRLSLWADRKVHASLSASEILYLTIAYDWFLFGHDLPDRIQKGE--------EVFHFCFNFLKYIGS-----------DTFS------------------------------------------------------------------------------------------------- Sp_MTMR14_Myotubularin_MTMR14_SpurP032 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSLPYPGCEFFKDFRDN-GFNG---------------------INLFFDWSQDFVDADLSIPDRVA-TSTGIDWHMYR--QWDLVKITQNYLKLLLFLI----KD---GDSGVLVHCISGWDRTPLFISLLRLSLWADCKAHANLSAAEILYLTIAYDWLLYGHNLCDRLGKGE--------DVFFFCFNFLKHITS-----------DDFS------------------------------------------------------------------------------------------------- Aq_MTMR9_Myotubularin_MTMR9_AqueP034 --FSPENMTSLFTRYKC---------PPD------DWRVSDCNR-GYKLCSSHPEEVIIPAKI---NDQEIGAVASFRQHGKFPILSYYNSKQRSVILRCGEPLC--G-TTLKRCKEDIKLLNSCLKIG-------------------------------------------------------K-GRIFDIRTQQAAQHHMSK-GGGV-EFPSNYSQWRVEY-GS---MESITNIQSSYLKLIDVCSD--------------------V---------NNSSWYGRLESSGWL--THVEQLLRAVKHVV-HSVYQ---EGTSVVLHGTNGCDGTLQVSSLAILLMDPQART------IRGFLQLIEREWLQGGHPFSLRHNIVSAA------PEKQKGPIFLLFLDAVWQIMRQYPLSFEFNELLLHILFVHSYSSSYGTFLYDNPAERDRH--KLREKTESLWDYILLSPDVMSSIINPLYSKN--S----TLLVVSVHPCSIVFWKRLYLRTDLSPT Ce_mtm-9_Myotubularin_MTMR9_CeleP133 -GWSAFDLEQEFARLML---------STD------AFRISSVNE-NFAICPTYPEKLIVPKGI---GDDYLKISATFREGGRFPVLSYFHKETKSPLVRCSQPLI--G-PTNRRCREDETILNSMITVN-------------------------------------------------------R-GYIIDTRSKSSATAAKAK-GGGA-EPQGNYRQWRYIQ-CP---IPRQREIHDALTRMVDVCSE--------------------RK-V------TSDRWVSRVGQAGWL--SSVAASLEAAANVA-QCIYNERLEEVPVVIHGGDGLDSTLIASSLAQILLDADART------IRGFESVIEREWICGGHPFSLRNNHCAYAEG--TVTGPFESPVFLVFLDAVHQMIAQYPMSFEFDENFLIFLFEHAYASEFGSFLGNCEKEKKDN--GIRKKTVSLWSHVHH-PENMKQFVNVCYDPT--P----GVIWPSIAPQCIKIWDRLFFRWQRPD- Dm_CG5026_Myotubularin_MTMR9_DmelP033 ---------GGALQSPQ---------ASC------EWRITNVNR-DFSVCATYGATLIVPKAI---TDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLS--I-QGIKRCRADEAILNLVLGRS------------------------------------------------------RK-GFIVDTWGKG---------KSNT-ETDLHYSQWKKVN-RSIGNVSSPASILDSFARLIEACND--------------------LG-C------STDKWLSRLENSGWL--SLVLNSLNASCVVA-QCLDQ---EGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRT------VRGLQALIEREWIQAGHPFASRHRYSCYTPN--QTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNEL--NVHTRTTSLWSYLNR-PDVLQTFLNPLYEPN--A----NVIWPSVAPISLELWSDLYLRWVIDQ- Hs_MTMR9_Myotubularin_MTMR9_HsapP060 -GWHSFLPEQEFELYSS---------ATS------EWRLSYVNK-EFAVCPSYPPIVTVPKSI---DDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLT--G-TNGRRCKEDEKLINATLRAG------------------------------------------------------KR-GYIIDTRSLNVAQQTRAK-GGGF-EQEAHYPQWRRIH-KS---IERYHILQESLIKLVEACND--------------------QT-H------NMDRWLSKLEASNWL--THIKEILTTACLAA-QCIDR---EGASILIHGTEGTDSTLQVTSLAQIILEPRSRT------IRGFEALIEREWLQAGHPFQQRCAQSAYC----NTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKL--KLQQKTMSLWSWVNQ-PSELSKFTNPLFEAN--N----LVIWPSVAPQSLPLWEGIFLRWNRSS- Mb_MTMR9_Myotubularin_MTMR9_MbreP025 ---------------------------------------------------------------------FSRSVSKYRQNGRFPMLCFLHPKTKMPLLRSGQPLA--G-SSGKRKYEDEQMLRMVLSTAD----------------------------------------------------VKQ-GLILDTRTSSVASTHRSK-GGGL-EVIDKYYGWSRKM-LD---IAAWPILADSLSKLLEACQD--------------------PS-L------DASKFLEKLNASNWL--STVRDALSAALQAV-TCLEH---EQQPVVVHGSHGTDITCIVVALAQLYMDPYFRT------LEGFCKLVEKEWLHAGHPFASRWSPLTRH------NKTERAPVFLLFLDCVYQSYFQFCAAFEFNESFLMELYMQSYSCVFGTFVGDCEAMRAAE--QLDKKTRCFWRHALS-PEQRPRFANPLYDAAVNK----GTICPSPRPQAIVLWRNLYCWRSYWEL Nv_MTMR9-2_Myotubularin_MTMR9_NvecP033 -GWDMFSNDLDFAKVCS---------STQ------SWRISHVNI-NYEVCASYPTSVIVPLGV---SDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLC--GSMSNKRCKEDEKLVNSALGSM------------------------------------------------------KK-GMIVDTRSTPAVMNSRSK-GGGL-EPESNYPQWKRSN-HN---IEKHTVLIDSVCKLMEACFD--------------------QN-L------SMNAYLSRLESCGWM--DQIQAVLGTACYVA-HCLHT---DGIPVLVHDGAGLDATLQVTSLSQVILDPDCRT------VRGFQSLVDREWIRGGHPFSNRCTRVGFS----STKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTV--KLKEKTISLWSYLNQ-DEILEDMLNPMYERN--E----SVLWPSVAPQSLVLWPGLYLKWQKQQ- Nv_MTMR9-1_Myotubularin_MTMR9_NvecP034 -----------------------------------------INL-FFQVCASYPTSVIVPLGV---SDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLC--GSMSNKRCKEDEKLVNSALGSM------------------------------------------------------KK-GMIVDTRSTPAVMNSRSK-GLKI-A-------------LT---TPNVLSFKDCHPLLFLWETP--------------------H---------------LRLSAPHHA--SVVQFLI--------------------------------VVVVLFAIVPLEVYLGH----CLGSRFQSLVDREWIRGGHPFSNRCTRVGFS----STKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQV-------------------------------------------------------LWPGLYLKW----- Sp_MTMR9_Myotubularin_MTMR9_SpurP038 -GWHAFLPENEFARLAS-----------D------DWRISYVNK-NFQVCPSYPPAVIVPKSI---DDDTLVQSAAFRYGGRFPILSYMHTAQKTVILRSSQPLT--G-TNTKRCKDDERLLNAALSVG------------------------------------------------------KR-GYIIDTRSMNGAMAARTK-GGGF-ETEVNYPQWRRVN-KP---LDKPSILQESLCKLLEACMD--------------------TG-C------SADKWISRLTNCGWL--HHVKETLTTACLVA-QCVDR---ENSAVLVHGSEGLDASLQVTSLAQVILDADCRT------VRGFEALIEREWIQAGHPFLSRCSKSVFS----QNKNKYAGPVYLLFLDCVWQIFQQFPCSFEFSEKFLIMLFENAYASRFGTFLCNNENERKMA--RVSEKTVSLWTYVNR-PQILQTFFNPLYQPN--Q----QVIWPSVAPQSLALWSSLYMRWTMSD- Aq_MTMR3_Myotubularin_MTMR3_AqueP030 -SLSTELLTSEYSRLGF------------NK--PGTWRITDANA-KYELCSSYPKVFVVPQSV---TDSDLLQVSKFRSLSRLPAVVWRHKGNGCVLARASQPLV--G-FLGWRCQEDEQFLKALSKSCHPHAPPMEVMS---HGE-------KIT---------------------NGVGQTPS-LLVVDLRSYTAAFGNRAK-GGGC-EHQDYYSNCEIVY-KG---LPNIHSVRTSFGSLRNLLSG--------------------N---------EQIRFFSQLEGTHWL--QNISQLLQTAVEVS-NTLHH---HSRPVLIHCSDGWDRTTQITSLAQLLLDPYYRS------LEGFRVLVEREWLSFGHKFSDRCGFGP----D-----GEQSPVFLQWLDCLYQISNQFPTSFEFNSIFLVKLAQHCYSQLYGTFLGNCEQERERE--LVRLQTLSLWDCL---EK-EREITNAIYKENGDE----VVLCPNYQVRSLKLWRELFLHLPLTRY Ce_mtm-3_Myotubularin_MTMR3_CeleP130 -SVAQEITHIDFNRLGM----------------SEHFQISSVNE-NFEVCPTYPEKIIVPKGI---TDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRSSQPQV--G-ILSWRNPTDEKIIEEAVKASRIEGE-----------------------------------------------EKKQ-FIIMDARGYTSAFANRAR-SGGF-ENTEYYQQAKLEF-LG---LPNIHAVRGSFNNVRTMLHN--------------------L--G------PNEQLLTSLQTTGWL--LNLSNLLVNAANCA-DHLSK----GHSVLVHCSDGWDRTTQVTTLAKIMLDEYYRT------VKGFEELIRRDWIAFGHKLYDRQLVAF----GNWGTSDERSPVFLQFLEAVRHLQREQPTLFQFTHAYLIKLAKHAYSGLFGSFLFNSHKERREAMEKCKGTLVDIWRFI---GPHNEEYVNQSFDEHYTG----AVKPVNVSVINLRVWHEVFADEEEHY- Dm_CG3632_Myotubularin_MTMR3_DmelP030 -VRYESDFKNEVARLGF------------DL--KGSWRISTANA-DFKLCPSYPPKLLVPCCI---TDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEV--G-WLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKK-ILIVDARSYTSAVTNRAR-GGGC-ECIEYYPCAEIEF-MN---LGNIHAIRKSFHAVRQLCAS--------------------S--P------DDPNWYGQLEKTMWM--QHLSGLLGATMTVV-HTIEK---NGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRT------VEGFRVLVEREWLNFGHKFADRSGNGP----N-SDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN--SVFDRTFSVWPFL---A--ETMYRNPLYKHET-E----KVLWPAHSVRFLYFWSDVYLGSLGNK- Hs_MTMR3_Myotubularin_MTMR3_HsapP053 -EHVTSRFKNEVERMGF------------DM--NNAWRISNINE-KYKLCGSYPQELIVPAWI---TDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV--S-WWGWRNADDEHLVQSVAKACASDSRS--SGSKLSTRNTSRD-F-PNGGDLSDV--EFDSSLSNASGAESLAIQPQK-LLILDARSYAAAVANRAK-GGGC-ECPEYYPNCEVVF-MG---MANIHSIRRSFQSLRLLCTQ--------------------M--P------DPGNWLSALESTKWL--HHLSVLLKSALLVV-HAVDQ---DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRT------IEGFQVLVEMEWLDFGHKFADRCGHGE----N-SDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEK--HTQERTCSVWSLL---RAGNKAFKNLLYSSQS-E----AVLYPVCHVRNLMLWSAVYLPCPSPT- Hs_MTMR4_Myotubularin_MTMR3_HsapP054 -EHIRCRQEAELARMGF------------DL--QNVWRVSHINS-NYKLCPSYPQKLLVPVWI---TDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEI--S-WWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGN-------NDTSEACDA--DFDSSLTACSGVESTA-APQK-LLILDARSYTAAVANRAK-GGGC-ECEEYYPNCEVVF-MG---MANIHAIRNSFQYLRAVCSQ--------------------M--P------DPSNWLSALESTKWL--QHLSVMLKAAVLVA-NTVDR---EGRPVLVHCSDGWDRTPQIVALAKILLDPYYRT------LEGFQVLVESDWLDFGHKFGDRCGHQE----N-VEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKR--NIYKRTCSVWALL---RAGNKNFHNFLYTPSS-D----MVLHPVCHVRALHLWTAVYLPASSPC- Nv_MTMR3_Myotubularin_MTMR3_NvecP029 -SATPYSFLEEVHRMGF------------ETGVDSPWRISDANS-SFEVCRTYPRLHVIPSSI---SDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQV--G-WLGWRSAEDELLLQAIGQACTSDRYPSVA--KLLNGITVNG-I-NKKHDMGDV--LNG--PADMSEDGPIARNPKQ-VLIVDARSYTAAYANRGK-GGGF-EYTEYYPNCEVMF-MN---LANIHGIRRSFHSLRALCSG--------------------S--Y------DVPNWWSLIEKTNWL--HHISMLIKSAVTIV-HAVHT---DGRPVVVHCSDGWDRTTQIVALAELLLDPFYRT------IEGFKILIDREWLQFGHRFADRCGHGS----D-I-DENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTD--AIKARTLSVWSYI---LPRKKDFRNLLYAGGG-D----QV------------------------- Sp_MTMR3_Myotubularin_MTMR3_SpurP033 -KVTHCKFGTEIDRQGF------------DL--KKAWRIFDN-S-DFKYCTTYPTQHIVPKEI---EDDAMKKSINFRTSKRFPSVVWRHKGNGAVIARCSQPAV--G-WLGWRSEEDERFMSAILDACAMDDPRKNKKSCHSNGYVKSEQY-RVTDDQ----------DEMRRGEYERSNQSKT-ILIIDARSYAAAFANRAK-GGGC-EYPEYYTCCDIEF-MG---LANIHSVRKSFNTVHALCSN--------------------NS-L------DQTTWLSNLEATKWL--QNLSMLLKAAIKVV-TAVDQ---EARPVIVHCSDGWDRTPQIVALAEIMLDPYYRT------MQGFQALVEREWLDFGHKFADRCGHRP----G-QDDANERCPVFLQWLDCIHQLLRQYPTAFEFNETFLVKLVQHTYSCLFGTFLCNSLKARLKN--SIKERTCSVWSLI---VVEGNKYRNFLYDPKT-Y----KVLYPTCNIRELDLWIAVYLSETSHS- Aq_MTMR1-3_Myotubularin_MTMR1_AqueP024 -DWNVEAQLH-TDMARM---------MSD------NWKESPLNC-LYTLCPTYPPVVYIPKVV----------------RGRVPSLVWMDKVNGTFLLRSAQPLP--G-LSDKHSTEDETLLKYAITCYE----------------------------------------------------GEG-LMIFDARSSSAATGNRIM-GKGT-EDVSRYYRCKLTH-LD---IPNIHAVRESYEGLKQLALS--------------------T---------SSTRWYSSLESTQWI--EYISLILKGSYLIA-RLIKI---HSGSALIHCSDGWDRTAQLTSLTQIIIDSYYRT------IDGFLTLIAKEWLSYGHKFKERLGHPL--------NPNERSPIFLQFLDCVHQLMNQYPHAFQFNLSFLLTIAEHLNTGWFGTFLFNCHKERIEN--DVFVSTVPITAHF---NAMRDVYINLNYRET-K-----EIIMPTWTIRRLRLWEEYFLAWDGTS- Aq_MTMR1-4_Myotubularin_MTMR1_AqueP025 -GWEVYDPEAELKRMGV---------GND----GVPWRICHLNK-NYELCDTYTSTFSVPLNC---SDEMVQGVAQFRSKGRIPVLSWLHPVTQASITRCSQPLV--G-TMNRRSKEDEQYMQEILKAND---------------------------------------------------KSNK-LYILDARPKINAMTNVAM-GGGY-EHEDCYVNMDFSF-LD---IGNIHVMRESLKKLREICYP--------------------D--V------DDQRWFSNLESSHWL--DHIKAILCGAVKVV-ECVET---HKSSVVVHCTDGWDRTAQITSLSMLMMDSYFRT------IKGFEVLVEKEWLGCGHKFSQRTGHGD-----KNHSDDQRSPIFLQFIDCVWQLMEQFPTAFEFNEHFLITILDHLYSCLFGTFLFNCERLRVEA--GVKDKTVSLWSFV---NSQIDVYKNPLYAELMN----NKVLFPRTSIRILKLWTGYYMRWNPRM- Aq_MTMR1-1_Myotubularin_MTMR1_AqueP022 -GWEVYDPEAELKRMGV---------GND----GVPWRICHLNK-NYELCDTYTSTFSVPLNC---SDEMVQGVAQFRSKGRIPVIQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Aq_MTMR1-2_Myotubularin_MTMR1_AqueP023 KLPNFFHFNAEMERTGI---------LNAKIGNTSLWRITTITKTNPDLCPSYPEKLVVLLCI---PDVDLLRGGRIYEEGRFPTATWMNKSNGSVLLRAAATTSERG-LQSSKLPVDEAILQAIRGCNA---------------------------------------------------NSRL--FVFTEKSDTSGFQDPNKLTKEA-ARSYYYHNCHFIYSVN---PPTYKSVRHSFNKLQAMLQS--------------------N--I------SDDEYMVTLDGTKWL--SRVGDLLDTAHKVV-EALTV---ESAHVLVCYEKGWDRTTQIVSLAQLLCDPYYRT------MDGFQVLIQKEWLWFGHPFQSRHSRSRAAVGGASSKIKEDGPVFLQWIDCVWQITRQCPFAFEFNENLLICFMI---------------PDHYHQ--SIYTNTISFWTWVSMVNSSNNIFFNNYYDPDFHK----GAIYPKFYQTCLEIWRTHYDRHKLRQE Ce_mtm-1_Myotubularin_MTMR1_CeleP129 -GWKIYSAEKEYERLGI---------PNS-----RLWKEVDINK-DYKFSETYPRTFVIPTVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMT--G-ISGKRSAEDERHLTNIMNANA---------------------------------------------------NCRE-LLILDARPAVNAKLNKAK-GGGY-E--ENYVNAPLTF-LN---IHNIHVVRDSLKRLLAALIP--------------------R--V------DEKGYYKALDESKWL--NHVQSILEGAVKAV-FNVDT---EKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRT------IEGFIVLIEKEWCSFGHKFGERIGHGD-----DNYSDGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKD-KKCDETTISFWSYV---LENKKKFRNPMFKHGKS----NKVINVNPSLCGLHVWIDYYARSNPYV- Dm_mtm_Myotubularin_MTMR1_DmelP027 -GWAVYEPLAELRRLGV---------PND------MWRATKLNE-SYAICDSYPAVWAVPKAA---SDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLV--G-VSGKRNSDDEAYLSFIMEANA---------------------------------------------------QSDK-LTIMDARPSANAIANKAK-GGGY-ESEDAYKNVEINF-LD---IHNIHVMRESLRKVKEACFP--------------------T--T------DDSKWQTAIDNTLWL--KHIRCILAGAVRIV-DKVET---MSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRT------VRGFEVLIEKEWLSFGHKFQQRIGHGD-----NKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAE--DLKHKTTSLWTHI---NSSLDQYLNPLFPSFTHG--AELVLRPIASVRSVRLWKGLYCRWNPGL- Hs_MTMR1_Myotubularin_MTMR1_HsapP047 -GWKVYDPVSEYKRQGL---------PNE------SWKISKINS-NYEFCDTYPAIIVVPTSV---KDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLV--G-PNDKRCKEDEKYLQTIMDANA---------------------------------------------------QSHK-LIIFDARQNSVADTNKTK-GGGY-ESESAYPNAELVF-LE---IHNIHVMRESLRKLKEIVYP--------------------S--I------DEARWLSNVDGTHWL--EYIRMLLAGAVRIA-DKIES---GKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRT------IKGFETLVEKEWISFGHRFALRVGHGN-----DNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKE--DVYTKTISLWSYI---NSQLDEFSNPFFVNYE-----NHVLYPVASLSHLELWVNYYVRWNPRM- Hs_MTMR2_Myotubularin_MTMR1_HsapP048 -GWKLYDPLLEYRRQGI---------PNE------SWRITKINE-RYELCDTYPALLVVPANI---PDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMV--G-VSGKRSKEDEKYLQAIMDSNA---------------------------------------------------QSHK-IFIFDARPSVNAVANKAK-GGGY-ESEDAYQNAELVF-LD---IHNIHVMRESLRKLKEIVYP--------------------N--I------EETHWLSNLESTHWL--EHIKLILAGALRIA-DKVES---GKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRT------IRGFEVLVEKEWLSFGHRFQLRVGHGD-----KNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKE--NLPKRTVSLWSYI---NSQLEDFTNPLYGSYS-----NHVLYPVASMRHLELWVGYYIRWNPRM- Hs_MTM1_Myotubularin_MTMR1_HsapP046 -GWTVYNPVEEYRRQGL---------PNH------HWRITFINK-CYELCDTYPALLVVPYRA---SDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLV--G-MSGKRNKDDEKYLDVIRETNK---------------------------------------------------QISK-LTIYDARPSVNAVANKAT-GGGY-ESDDAYHNAELFF-LD---IHNIHVMRESLKKVKDIVYP--------------------N--V------EESHWLSSLESTHWL--EHIKLVLTGAIQVA-DKVSS---GKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRS------IEGFEILVQKEWISFGHKFASRIGHGD-----KNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQ--KVTERTVSLWSLI---NSNKEKFKNPFYTKEI-----NRVLYPVASMRHLELWVNYYIRWNPRI- Mb_MTMR1_Myotubularin_MTMR1_MbreP021 -DWSRYDPMAEMRRQGLVFEEDVFSGSLS------AWMKSDLNR-DYELCPTYPPILFLPRMV---SESVIRGSAAFRSKQRLPVLTWYSDRGGRRR------------------------------SIV----------------------------------------------------RDQ-IAVFDARSMIAAGGNQIM-GKGS-ENSAFYVGAQVFF-ME---IGNIHTMRASHDKLLELCIG--------------------V---------SDVQWYSQLENTGWL--SHIKAVLSAARAIA-RKVEN---LAITALVHCSDGWDRTSQLVSLAQIMLDPYFRT------IDGLIVVIEKDWLAFGHKFDERHGGAD--------SVTERSPIFLQFLDCLYQMTVQHPTAFEYNSRLLVFLADYSRAGWFGNFQCNSHRERRAR--RLSQTTTSIWSAV---EADRPRFTSSQYAPGGS-----DVIMPTCSLKRIELWSDYFLRYDASV- Nv_MTMR1-2_Myotubularin_MTMR1_NvecP025 -GWDVYDAEKEFERLGL---------PTD------CWYVTRINE-KYELSDTYPAVVGVPSSV---SDEDIKKVAVFRSRNRLPVLCWLHPTNNASITRASQPNR--G-L-LARNKDDEKYFQAILEANP---------------------------------------------------QCHK-LLIFDARPRINAVANQAK-GGGY-ETEENYQNTEVIF-LD---IANIHVMRESLRKLKDICFP--------------------N--I------DDTHWLTNLENTKWL--DHIKMIMAGAVRIA-DAVDR---CRTSVVVHCSDGWDRTPQLTALAMLLMDPYYRT------IIGFEVLIEKEWLSFGHKFNQRYGHGD-----KNHADDQRSPVFLQFIDCVWQVTRQFPCAFEFNETFLITILDHLYSCMFGTFLYNSESQREKE--DVKTRTTSLWSYI---NTSMMEFKNPLYAPYLH----QHVLFPVPSLRRLELWTRYYIRWNPRM- Nv_MTMR1-1_Myotubularin_MTMR1_NvecP024 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFGMSGRPLCTFFCVQ---GKGTEDTLNRYQGCSLVF-LD---IPNIHAVRDSLDRLQAVCES--------------------S---------SQKKWLSHLESTQWL--AYIAAILKGATTIA-RFVDK---G-VSTLVHCSDGWDRTSQLTLLAQLLLDPYYRT------FTGFQVLIEKEWISFGHRFRDRLGHPT--------CPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHA--FITRTTVSLWSHL---NAVKDNYTNSIYQPT-------ETLVPVSSLRRLQLWSDYFLRYD---- Nv_MTMR1-3_Myotubularin_MTMR1_NvecP026 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RF------ISLFQVLIEKEWISFGHRFRDRLGHPT--------CPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHA--FITRTTVSLWSHL---NAVKDNYTNSIY------------------------------------- Sp_MTMR1_Myotubularin_MTMR1_SpurP029 -GWAVFDPVAEYKRQGL---------PTE------SWRISRINE-NFTFCDTYPAVLAIPAAA---DDELLRQVAAFRSRNRLPIMSWLHPQSQATITRCSQPLV--G-VGGKRSKEDEKYVQMILDANA---------------------------------------------------QSHK-LVIMDARPTVNAVANKAK-GGGY-ENEDTYQNAEICF-LD---IHNIHVMRESLRKLKDICFP--------------------S--I------DEHHWLANLEATHWL--EHVKMVLAGAVRIA-ERVEG---QKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRT------IRGFEVLIEKEWLACGHKMAQRHGHGD-----KNYTDADRSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLYSCLFGTFLFNCERERVKE--QVKTKTVSLWSYI---NSSMEEFINPMYASYMH----QHVLFPVASMRRIELWTSYYIRWNPRM- Aq_MTMR6_Myotubularin_MTMR6_AqueP033 -GWNLYDSVVEYGRMGV---------PNE------HWVCTELNK-DYELCETYSNTLFVPAKA---EKSVVLGSAKFRSKGRLPVLSYYCQAKNSALCRSSQPLT--Y-I-TRRSQEDEAMIQAIIDANP---------------------------------------------------NSSS-LHLLDSRPKINAVANKAAHKGGY-ETTDNYPNIVYQF-NN---IQNIHVMRESLQKLLEALHS--------------------P--A------GVSSVLQGLDASSWL--RHIHLVLEAGAFIA-KALYT---EGINVLVHCSDGWDRTAQTCSLASLMIDKYYRT------IHGFMILIEKEWLSFGHKFTIRSGHIN-------SDSKEVSPIFTQFLDAVWQIMVQFPKSFEFNELFLLTIHDHLFSCQFGTFLGNNERDRKIN--KFSEKTYSLWGYI---WSRLDDFTNPLFDNDTE-----NYIMPKTEVSILSLWRGLYCCYETG-- Ce_mtm-6_Myotubularin_MTMR6_CeleP132 -GWRRLDWNSEMTRQGI---------TKS------QWTESNINE-GYTICDTYPNKLWFPTAA---STSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLT--G-F-SARCVEDEKLMELVGKANT---------------------------------------------------NSDN-LFLVDTRPRVNAMVNKVQ-GKGF-EDERNYSNMRFHF-FD---IENIHVMRASQARLLDAVTK--------------------C--R------DVTEYWKTLEASGWL--KHVRSVVECSLFLA-ESISR----GTSCVVHCSDGWDRTSQVVALCQLLLDPYYRT------IHGFQVLIEKDWLGFGHKFDDRCGHVGA---LNDEAGKEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDL--NLSKRTKSLWTWM---DARHDDYMNPFYSPTAHV----ALLDLDTRAARFTVWTAMYNRFDNGL- Dm_CG3530_Myotubularin_MTMR6_DmelP032 -GWDYFKLEAEFKHMLV---------PNE------AWTLCSMNE-KYELCDTYPRQIYVPKEA---TTLMLISSSRFRSKGRLPVLTYLHN-NKASICRCSQPLS--G-F-SARCLEDEQMLEAIRKTNS---------------------------------------------------NTDY-MYVVDTRPRINAMANRAA-GKGY-ENEAFYENIKFHF-LG---IENIHVQRASLQKVLEACEQ--------------------KS-P------TMSAFINALESSGWL--KHIRSILDTSSFIA-NAVDK----GVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRT------IKGFQALIEKDWLAFGHKFSERCGHIQ-------TDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDL--KLAERTFSLWGYM---ANHLNEYINPLYKPNVD-----EAIKANLAPQCIKFWRGMYSRFESGI- Hs_MTMR8_Myotubularin_MTMR6_HsapP059 -GWKLIDPISDFGRMGI---------PNR------NWTITDANR-NYEICSTYPPEIVVPKSV---TLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLS--G-F-YTRCVDDELLLEAISQTNP---------------------------------------------------GSQF-MYVVDTRPKLNAMANRAA-GKGY-ENEDNYANIRFRF-MG---IENIHVMRSSLQKLLEVCEL--------------------KT-P------TMSEFLSGLESSGWL--RHIKAIMDAGIFIT-KAVKV---EKASVLVHCSDGWDRTAQVCSVASILLDPFYRT------FKGLMILIEKEWISMGHKFSQRCGHLD-------GDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDL--RVYEKTHSVWPFL---VQRKPDFRNPLYKGFTMY----GVLNPSTVPYNIQFWCGMYNRFDKGL- Hs_MTMR7_Myotubularin_MTMR6_HsapP058 -GWVLIDLSEEYTRMGL---------PNH------YWQLSDVNR-DYRVCDSYPTELYVPKSA---TAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLS--G-F-SARCLEDEQMLQAIRKANP---------------------------------------------------GSDF-VYVVDTRPKLNAMANRAA-GKGY-ENEDNYSNIKFQF-IG---IENIHVMRNSLQKMLEVCEL--------------------KS-P------SMSDFLWGLENSGWL--RHIKAIMDAGIFIA-KAVSE---EGASVLVHCSDGWDRTAQVCSVASLLLDPHYRT------LKGFMVLIEKDWISFGHKFNHRYGNLD-------GDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERREL--KIQERTYSLWAHL---WKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGM- Hs_MTMR6_Myotubularin_MTMR6_HsapP057 -GWQLIDLAEEYKRMGV---------PNS------HWQLSDANR-DYKICETYPRELYVPRIA---SKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLS--G-F-SARCLEDEHLLQAISKANP---------------------------------------------------VNRY-MYVMDTRPKLNAMANRAA-GKGY-ENEDNYSNIRFQF-VG---IENIHVMRSSLQKLLEVNGT--------------------KG-L------SVNDFYSGLESSGWL--RHIKAVMDAAIFLA-KAITV---ENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT------IKGFMVLIEKDWISFGHKFSERCGQLD-------GDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREEL--KLKEKTYSLWPFL---LEDQKKYLNPLYSSESHR---FTVLEPNTVSFNFKFWRNMYHQFDRTL- Mb_MTMR6_Myotubularin_MTMR6_MbreP023 -GWALYSPMAEYGRMGV---------PNP------QWQQVDYNN-TYNLCPTYGRTLYLPSSV---TMEQAFASAKFRSKQRLPVLSYLFQRNQAAICRCAQPLT--G-VQAKRSEDDEALLEFIRLCNP---------------------------------------------------HSELPLIIVDTRPRMNAMANKAA-GKGF-ENMEGYTNCRLEF-HG---IENIHTMRGSLNALVKASKR--------------------N--S------PCHDHQIGIQECAWL--KHIQAVLKTTMVIT-RYIQD----GHSVLVHCSDGWDRTAQTCSLAGLMLDPYYRT------IEGYIVLIEKEWLSFGHKFLDRNGFLK-------GSGREVSPIFLQLLECTWCLQRQFPLAFEFNESFLIAMHDCLHSCKFGTFLGNCEQARRDA--KLHERTQSAWSYL---YSRKSEFINPFYDASQDP--EGGVLNPSLAPQHFELWSAMYCRWESAS- Nv_MTMR6_Myotubularin_MTMR6_NvecP031 -GWALFDIKSDYTRMGV---------PSD------LWTATQLNK-DYELCDTYPNILYVPKSA---TKEVLVGSSRFRSRGRLPVLSFYHKSTQAAVCRCSQPLG--G-F-KGRCPEDEQMIQALLNSNP---------------------------------------------------NSKF-IYIVDTRPRLNALANRAA-GKGY-ESEDFYENVKFQF-VG---IENIHVMRQSLFKMLEVVGE--------------------SPKT------PAGAFYSGLEASNWL--KHIKNILDTSVFIA-KAVAM---EKASVLVHCSDGWDRTAQTCSLASIILDPYYRT------IHGFQVLIEKEWLSFGHKFTDRCGLLQ-------SDQKEFSPVFLQFLESIWQLLQQFPFSFQFNERFLLTLHDHVYSCQFGTFLGNCQKERRDL--GLPKRTYSLWGYM---WQNISDYANPLYREVTQ----DDALWPDTSPQAIRFWRAMYNRYDNEV- Sp_MTMR6_Myotubularin_MTMR6_SpurP036 -GWDQFDLQAEYARMGI---------PNA------HWCSTAINK-NYEICDTYSRTLYVPTHA---SPPVLVGSSRFRSRGRLPVLSYLHQENNKRLRGRVTFD------------------------------------------------------------------------------------------------------------------------------VNQNLALEILRPLSDNFSL--------------------KN-P------SMEAFLSGLESSQWM--KHIKAVLDTSLFIA-KAIAD---EGLSVLVHCSDGWDRTAQTCSLASIILDPYYRT------IQGFQVLIEKEWLAFGHKFLHRCGLLA-------YDPREVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDK--KLSQKTFSLWQYM---QARMSDYINPLYKANHPSA--NGILKPNFSPQMLKFWRGMYNRYENGV-