88 169 CDC14A hpk-----------------Skiengy-plhapeaYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPS-DNI---VRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRF-THAEIIAWIRICRPGs---iIGPQQHFLEE----------- CDC14B wii-PD-RFIAF-cGP-H-SRarlesgyhqhspetYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPT-DAI---VKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRM-TAAETIAWVRICRPGs---vIGPQQQFL------------- CDKN3 rrn--------------V-QK--------------DTEELKSCGIQDIFVFCTRPNLLDLYQQCGIITHHHPIADGGTPD-IASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTiSPEQAIDSLRDLRGS----gAIQTIKQYNYLHEFRDKLAAH DUSP1 pveILP-FLYLG--SAYH-AS--------------RKDMLDALGITALINVSA--NCPNHF-EGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRV-KLDEAFEFVKQRRSI-----ISPNFSFMGQLLQFESQVL-- DUSP2 pveILP-YLFLG--SCSH-SS--------------DLQGLQACGITAVLNVSA--SCPNHF-EGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRV-RLDEAFDFVKQRRGV-----ISPNFSFMGQLLQFETQV--- DUSP4 pveILP-FLYLG--SAYH-AA--------------RRDMLDALGITALLNVSS--DCPNHF-EGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRV-RLEEAFEFVKQRRSI-----ISPNFSFMGQLLQFESQVL-- DUSP5 pveILP-FLYLG--SAYH-AS--------------KCEFLANLHITALLNVSRR--TSEAC-ATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQF-RLKEAFDYIKQRRSM-----VSPNFGFMGQLLQYESEILPS DUSP10 ltpILP-FLFLG--NEQD-AQ--------------DLDTMQRLNIGYVINVTTHLPLYHY-EKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRM-TMTDAYKFVKGKRPI-----ISPNLNFMGQLLEFEEDLNNG DUSP11 ecf-----------SPLD-LF--------------NKIREQNEELGLIIDLTYTQRYYKEDLPETVPYLKIFTVGHQVETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGV-RPDDAIELFNRCRGH-----CLERQNYIEDLQNG------- DUSP12 lev-QP-GLYFG--GAAA-VA--------------EPDHLREAGITAVLTVDSEEPSFKGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQL-PFEKAYEKLQILKPE-----AKMNEGFEWQLKLYQAMGYE- DUSP14 iaqITS-SLFLG--RGSV-AS--------------NRHLLQARGITCIVNATIEIPNFN---WPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNV-CLLEAYNWVKARRPV-----IRPNVGFWRQLIDYERQLFGK DUSP18 lsqITK-SLYIS--NGVA-AN--------------NKLMLSSNQITMVINVSVE--VVNTL-YEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAM-SLLDAHTWTKSCRPI-----IRPNSGFWEQLIHYEFQLFGK DUSP21 fsqITR-SLFLS--NGVA-AN--------------DKLLLSSNRITAIVNASVE--VVNF--FEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSM-SLLDAHTWTKSRRPI-----IRPNNGFWEQLINYEFKLFNN DUSP28 vrv-AP-SLFLG--SARA-AG--------------AEEQLARAGVTLCVNVSRQQPGPR---APGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGL-SLAKAFQMVKSARPV-----AEPNPGFWSQLQKYEEALQAQ DUSP15 mtkVLP-GLYLG--NFID-AK--------------DLDQLGRNKITHIISIHE--SPQPL--LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGL-GWRDVLEAIKATRPI-----ANPNPGFRQQLEEFSQK---- DUSP22 mnkILP-GLYIG--NFKD-AR--------------DAEQLSKNKVTHILSVHDSARPML----EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDF-GWEDALHTVRAGRSC-----ANPNVGFQRQLQEFEKHEV-- DUSP19 vgvIKP-WLLLG--SQDA-AH--------------DLDTLKKNKVTHILNVAYGVENAF---LSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQT-SFTSAFSLVKNARPS-----ICPNSGFMEQLRTYQEGKES- DUSP23 prl----------------PA--------------HYQFLLDLGVRHLVSLTERGPPHSD-SCPGLTLHRLRIPDFCPPA-PDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGL-AAGDAIAEIRRLRPG-----SIETYEQEKAVFQFYQR---- DUPD1 vneVWP-KLYIG--DEAT-AL--------------DRYRLQKAGFTHVLNAAHGDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDSKILVHCVMGRSRSATLVLAYLMIHKDM-TLVDAIQQVAKNRCV------LPNRGFLKQLRELDKQLVQQ DUSP13 dev-WP-SLFLG--DAYA-AR--------------DKSKLIQLGITHVVNAAAGDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSPQGRVLVHCAMGVSRSATLVLAFLMICENM-TLVEAIQTVQAHRNI------CPNSGFLRQLQVLDNRLGR- DUSP26 adeVWP-GLYLG--DQDM-AN--------------NRRELRRLGITHVLNASHSWRGTPAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSPGGKILVHCAVGVSRSATLVLAYLMLYHHL-TLVEAIKKVKDHRGI------IPNRGFLRQLLALDRRLRQ- DUSP27 dev-WP-NVFIA--EKSV-AV--------------NKGRLKRLGITHILNAAHGVYTGPFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTRGKVLVSSEMGISRSAVLVVAYLMIFHNM-AILEALMTVRKKRAI------YPNEGFLKQLRELNEKLMEE DUSP3 cneVTP-RIYVG--NASV-AQ--------------DIPKLQKLGITHVLNAAEGNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALQKNGRVLVHCREGYSRSPTLVIAYLMMRQKM-DVKSALSIVRQNREI------GPNDGFLAQLCQLNDRLAKE DUSP6 pveILP-FLYLG--CAKD-ST--------------NLDVLEEFGIKYILNVTPNLPNLFEN-AGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNL-SMNDAYDIVKMKKSN-----ISPNFNFMGQLLDFERTLG-- DUSP7 pvqILP-YLYLG--CAKD-ST--------------NLDVLGKYGIKYILNVTPNLPNAFEH-GGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNL-SLNDAYDFVKRKKSN-----ISPNFNFMGQLLDFERTLG-- DUSP9 pvqILP-NLYLG--SARD-SA--------------NLESLAKLGIRYILNVTPNLPNFFE-KNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHL-SLNDAYDLVKRKKSN-----ISPNFNFMGQLLDFERSLRLE DUSP16 ptrILP-NLYLG--CQRD-VL--------------NKELMQQNGIGYVLNASNTCPKPDF--IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDM-SLDEAYRFVKEKRPT-----ISPNFNFLGQLLDYEKKIKNQ DUSP8 ltrILP-HLYLG--SQKD-VL--------------NKDLMTQNGISYVLNASNSCPKPD-F-ICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGM-SSDDAYRFVKDRRPS-----ISPNFNFLGQLLEYERSLK-- EPM2A ysrILP-NIWLG--SCPR-QVe-----------hvTIKLKHELGITAVMNFQTEDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGW-NLRKVQYFLMAKRPA-----VYIDEEALA------------ PTP4A1 rfl------ITH--NPTN-ATl-----------nkFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPS-NQIVDDWLSLIKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGM-KYEDAVQFIRQKRRG------AFNSKQLLYLEKYRPKMRL- PTP4A2 rfl------ITH--NPTN-ATl-----------nkFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPP-NQIVDDWLNLLKTKEEPGCCVAVHCVAGLGRAPVLVALALIECGM--KYEDAVQFIRQKRRG------AFNSKQLLYLEKYRPKMR-- PTP4A3 rfl------ITH--NPTN-ATl-----------stFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPP-GKVVEDWLSLVKACEAPGSCVAVHCVAGLGRAPVLVALALIESGM--KYEDAIQFIRQKRRG------AINSKQLTYLEKYRPKQR-- PTPDC1 swv-TD-NILAM--ARPS-SElle--------kyhIIDQFLSHGIKTIINLQRPTYLPEAFMEAGIYFYNFGWKDYGVAS-LTTILDMVKVMTFALQEG-KVAIHCHAGLGRTGVLIACYLVFATRM-TADQAIIFVRAKRPN-----SIQTRGQLLCVREFTQFLTPL PTPMT1 yhrIDP-TVLLG--ALPL-RS-------------lTRQLVQDENVRGVITMNEELCNSSEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKW-SPEEAVRAIAKIRSY-----IHIRPGQLDVLKEFHKQITAR RNGTT enr--------F--HPSM-LS--------------NYLKSLKVKMGLLVDLTNTSRFYDDIEKEGIKYIKLQCKGHGEENTETFIRLCERFNER--NPPELIGVHCTHGFNRTGFLICAFLVEKMDW-SIEAAVATFAQARPP-----GIYKGDYLKELFRRYGDIEE- SSH1 pslIFD-HLYLG--SEWN-AS--------------NLEELQGSGVDYILNVTR--EIDNFF-PGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGW-PLEKAYNYVKQKRSI-----TRPNAGFMRQLSEYEGILDAS SSH2 ptqIFE-HVFLG--SEWN-AS--------------NLEDLQNRGVRYILNVTR--EIDNFF-PGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGW-NLDRAYDYVKERRTV-----TKPNPSFMRQLEEYQGILLAS SSH3 asrIFP-HLYLG--SEWN-AA--------------NLEELQRNRVTHILNMAR--EIDNFY-PERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYEC-SLEQALRHVQELRPI-----ARPNPGFLRQLQIYQGILTAS STYX mqeILP-GLFLGpySSAM-KS--------------KLPVLQKHGITHIICIRQNIEANFN-FQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGM-KYRDAFAYVQERRFC-----INPNAGFVHQLQEYEAIYLAK STYXL1 eiv--PgKVFVG--NFSQ-AC--------------DPKIQKDLKIKAHVNVSMDTGP--FFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQ-TLQRSWAYVKKCKNN-----MCPNRGLVSQLLEWEKTILGD Dm_cdc14 vpq----KFIAF-cGPHQ-KSktlpngypchaperYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPS-DAI---MKKFLSICETTKGAIAVHCKAGLGRTGSLIGAYIMKHYGF-TALEAIAWLRLCRPGs---vIGHQQQWMEDKQSWE------ Dm_puc pvf--P-HLLLG--NGRD-AD--------------DPS---SVGANCVLNVTCQSPNESH--LQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSL-SLLEAYKLVKVARPI-----ISPNLNFMGQLLELEQNLRKS Dm_CG13197 ivp----------------------------------------DMGLIIDLTNTNRYYHAITNHDVLHQKLMIPGKQTKLAQRFCAFVTDFLERNADNDKLIGVHCTHGVNRTGYLICYFMISVMNM-SPEEAIQTFSLARGH-----EIERDNYLSSLKTLPN----- Dm_MKP-4 dev-DT-GLFLG--NLTA-AT--------------HMETLRSFKITHILTLDSVPLPQHILEASFLTTKYIQIADMPREDILQHLEGCVDFISSALAQQGNVLVHCYFGVSRSSSTVIAYMMKRHNL-DFLPAYELVKAKRRF-----VQPNAGFVSQLKLFRRMGC-- Dm_CG15528 lsrITP-SLILC--GAA--AV--------------VPAYMDKLGVSCVINVAPELPDTPLPSQKNPLYLRIMAQDRSEVDLAKHFDEAADLIEEVHLSGGCTLIHCVAGVSRSASLCLAYLMKHAGM-SLREAYKHVQAIRPQ-----VRPNSGFFQQLRRYEQQLRGS Dm_CG10089 mnkVLP-GLYVG--NYRD-SK--------------DHAQLERFKISHIIAIHDS---PRRL-LPDKHYLCVMASDTPDQNLSQYFSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHL-NWKEALKVVRAGRAV-----ANPNAGFQSQLQEFEQFKLSE Dm_Mkp ils--D-FLYLG--SQDA-V---------------SADNIIKYKITHILSVGIQ-TPEVEW-PLPVNCTFLPCLDLPETNLMNYIPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDM-CYEDAYNLVKSWRPC-----IQPNAGFIQQLKR-------- Dm_CG7378 dev-YP-GIYIG--DAAA-AK--------------NKTYLRLMGITHVLNAAEGIRR--SHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKM-SAVDAIRTVRMRRDI------RPNDGFLQQLADLDMELKRK Dm_Mkp3 ipg----LLFLG--NATH-SC--------------DSEALKKYNIKYVLNVTPDLPNKFK-ESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGL-SLNDAFAMVRDRKPD-----VSPNFHFMQQLLSFESQLRLR Dm_PRL-1 iti----------------NH--------------YIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPP-QQVVDEWFEVLKDKQNPEACVAVHCVAGLGRAPVLVALALIE-LGL-KYEAAVEMIRDKRRG------AINAKQLSFLEKYKPKARLK Dm_Plip ydrIDE-HVILG--ALPF-RS--------------QANDLIEKNMKAVVSMNEDSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLKGSVYVHCKAGRTRSATLVGCYLMMKNGW-TPDQAVDHMRKCRPH-----ILLHTKQWDALRLFYTN---- Dm_mRNA-cap ctf-----------QPEM-LF--------------EYCKTLKVKLGLWVDLTNTKRFYDAVEELGAKYIKLQCRGHGEEQTHSFIEIVDNFINE--RPFDVIAVHCTHGFNRTGFLIVCYLVERLDC-SVSAALAIFASARPP-----GIYKQDYINELYKRYEDTNA- Dm_ssh ptkIFE-HVYLG--SEWN-AS--------------NLEELQKNGVRHILNVTR--EIDNFF-PGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQW-EFQQALEHVKKRRSC-----IKPNKNFLNQLETYSGMLDAM Ce_cdc-14 hne-----------------Sreengy-pyhapdvYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPS-DEI---MLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGL-TAGECMGWLRVCRPGs---vIGPQQPYLIEKQKF------- Ce_W09H1.1 ted---------------------------------------------------------------------------TKLNDMFDGFLDLVQRARRAKRNVLVCSTRGRNRAPAFASAYLMSKEQI-PRQAAVAKVRTAMGTmr-ppVNISDFMQRKLMRYQQ----- Ce_F54C8.4 ttn--------------D-LF--------------RQLSERGQYLGLVVDLSDTDRYYDDITGMCVQYEKVNCPGRGFDCVESFHQVIQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGW-SSHEAIDAFEQARGY-----SIEKGAYVMALHKAAKDKRDK Ce_T23G7.5 gvk--------------T-LI--------------SLAQQANKQIGLVIDLTNTDRYYKEWADHGVKYLKLNCPGHEVDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNY-SASDAISMFEYYRGH-----PMEREHYKKSLYEAERKKK-- Ce_C24F3.2 mwkITE-NLYLA--QLPM-IVg-----------ptSKQEFSKNDIKRVLTLTTE-PISEKQKIGGVDYKFLHLLDMPDEPILDILETAVLYINEGVEKEENVGVHCLAAVSRSVSICAAYLMYKNQW-PVEKALKMIESVRKT-----IGPNAGFLAQLKIWERSGM-- Ce_C04F12.8 mseIND-HLYLS--GAGV-LK---------------PDKIKQRKINMIVNATTE--EPSTY-MQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHM-TLRQAYHYVKAARPI-----IRPNVGFWKQMVDYEKRLRGT Ce_F13D11.3 gci--------------------------------TPSLLKQYNITHGVDCTN--LKTKP--IKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENL-SLEEAYLQVNQVRPI-----ISPNIGFWRQMIDFEKQRNGN Ce_F26A3.4 mseIVP-GLFIC--GVSA-LS---------------KDEMKKHKITHIINATTEVPNLRS--LGDIQRTKLWLEDTPQTYIYPHLELQSDQIQALIADGGKVLVHCVAGVSRSASICLAFLLKYRCR-NLREAYHLMKSKRSM-----VRPNLGFWRQLIAYEQNVKEN Ce_ZK757.2 lsa-----------------------------------------------------------PPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKK-TLHDSYKAVQLARNI-----ICPNVGFFQQLIDLEQKLRGK Ce_C16A3.2 iseILP-NLYLS--GRTV-SQ--------------NSELLKEKNITTVINVSDRV-NYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISALSI-NWRDAVDFIHHRRFS-----ANPNFGFLHQLKVYSTTKAK- Ce_Y54F10BM.13 eal--P-DLLFG--SQDV-AA--------------DLPILENRKITHIVNVGT--GIPNHF-PKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI-SCREAMDKCRETRSI------RPNTGFAQQLKEYEAILV-- Ce_lip-1 vkl-TN-FLYLG--NAET-AK--------------NRDVLKKYSISHVINVTSNLPNTFE-EDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMC-TLDSAYEWVQKRNAS-----IAPNFHFMGQLTDYEKMLGLN Ce_vhp-1 itlITP-NIYLG--SQID-SL--------------DETMLDALDISVVINLSMTCPKSVCI-KEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKM-GSDDAYRYVKERRPS-----ISPNFNFMGQLLEYENVLI-- Ce_PRL pnn-----------------Ssi----------qsYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPEVIKSWFQLCMTSFKE--HPDKSIAVHCVAGLGRAPVLVAIALIEAGM--KYEDAVEMIRTQRRG------ALNQKQLKFLETYKANGE-- Ce_PTPDC1 qve-----------------Hfd---------slgIVEKFKTNGIQSVINLQESSYDPENLMRNGIYHYNFPLPDFQACT-PNRLLDIVKVVDFALSHG-KIAVHCHAGHGRTGMVIAAWMMYALGM-SPSQAVDTVRSRRAK-----AVQSKEQVKTLHEFRLLIRN- Ce_PTPMT1 nrv-DE-TLILG--AMPFrSM--------------KDELIQKENVGGVVCCTEEA-MREDWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNW-MSNVAWEFLKDKRHQ-----VLLRNAHWRTVNEYRRFLDSN Ce_cel-1 nqi-AE-RRYQF--HPAE-VF--------------SHPHLHGKKIGLWIDLTNTDRYYFEVTEHECIYHKMKMAGRGVEDTDNFIKLVQEFHKK--YPDRVVGVHCTHGFNRTGFLIAAYLFQVEEY-GLDAAIGEFAENRQK-----GIYKQDYIDDLFARYDPTED- Sc_CDC14 vlt--P-DFIAF-aSPPF-KS--------------VLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPD-LSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGF-TANECIGFLRFIRPGm---vVGPQQH-WLYLH--------- Sc_YVH1 tri-LG-GIYLG-gIRPI-ID--------------HRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGL-SLSMAMHAVKRKKPS-----VEPNENFMEQLHLFEKMG--- Sc_MSG5 ppn-----LYLY--SEPK-LE--------------DI-----LSFDLVINVAKEIPNLEFLMAHKIKYYHIEWTH--TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGL-SLNDAYNKLKGVAKD-----ISPNMGLIFQLMEWGTMLSKN Sc_SDP1 llp-----------------------------------------FDVVINVAEEANDL-RMQVPAVEYHHYRWEHDSQ--IALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNL-SLRHSYDLLKSRADK-----INPSIGLIFQLMEWEVALNAK Sc_PPS1 cnk-------------------------------------SRNRADTVVSDKQENGSNVISENSGFQICQIENLDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQC-DLASAYLFVRVRRLNv---iIQPNLFFVYELFKWWKKHYNR DNAJC6 tyv-TS-RIIVM--SFPL-DNvdigfr-nqvddirSFLDSRHLDHYTVYNLSPKSYRTAKF-HSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQ-NPKNVCVVHCLDGRAASSILVGAMFIFCNLYsTPGPAIRLLYAKRPG-----IGLSPSHRRYLGYMCD----- GAK isyITS-RIAVM--SFPA-EGvesalk--nniedvRLFLDSKHGHYAVYNLSPRTYRPSRF-HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKN-VCVVHCMDGRAASAVAVCSFLCFCRLFsTAEAAVYMFSMKRCPp--giWPSHKRYIEYMCDMEEPITPH PTEN ltyIYP-NIIAM--GFPA-ERlegvyr-nniddvvRFLDSKHKNHYKIYNLCAERHYDTA--KFNCRVAQYPFEDHNPPQ-LELIKPFCEDLDQWLSENHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVRTRd--kkGVTIPSQRRYVYYYSYLLKNH TENC1 ela--------------------------------HVLQSKHRDKYLLFNLSEKRHDLTR---LNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSPQHVVVLYCKGNKGKLGVIVSAYMHYSKISaGADQALATLTMRKFCedkvaTELQPSQRRYISYFSGLLS-- TNS1 mdt----------------------------------------------------------------------------------------WLNA-DPHNVVVLHNKGNRGRIGVVIAAYMHYSNISaSADQALDRFAMKRFYedkivPIGQPSQRRYVHYFSGLLS-- TNS3 ltyITE-RIIAV--SFPA-GCseesyl-hnlqevtRMLKSKHGDNYLVLNLSEKRYDLT---KLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSNHVVVIHCRGGKGRIGVVISSYMHFTNVSaSADQALDRFAMKKFYddkvsALMQPSQKRYVQFLSGL---- TPTE ltyVTE-RIIAM--SFPS-SGrqsfy---rnpikeVVRFLDKKNHYRVYNLCSERAYDPK--HFHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWMAQENIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDktkfqGVETPSQKRYVAYFAQVKHLY TPTE2 ltyVTE-RIIAM--SFPS-SGrqsfy---rnpieeVVRFLDKKNHYRVYNLCSERAYDPK--HFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMAQENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNktkfqGVETPSQNRYVGYFAQVKHLY Dm_aux ppv--------------------------------------------------------R-TVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLrEPEDAVQVFAVKRHT-----INLRPSEFRYLYYFGDILRP- Dm_Pten ltyIND-NIIAM--GYPA-PDkleglfrnrledvfKLLEEN-HQHYKIYNLCSERSYDVA--KFRGRVAVYPFDDHNPPT-IELIQRFCSDVDMWLKEDNVVAVHCKAGKGRTGTMICAYLVFSGIKkSADEALAWYDEKRTKd--rkGVTIPSQRRYVQYFSKLVCS- Ce_daf-18 cayITD-RIIAI--GYQT-QQ--------------FLTRRHGKGNVKVFNLRGG-YYYDAD-NFDGNVICFDMTDHHPPS-LELMAPFCREAKEWLDDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILDYYSIIRTKn--nkGVTIPSQRRYIYYYHKLRER- Ce_tag-83 eyi-TS-RLIVL--SCTS-ETserkfvesllkasqQIQNAH-NKHIRVWNVSQRRHDIS----SSLDAIPFGWPSETAPS-LEKLCTICKNLDQWMLEHNIAVIFCKGGLERCAIVVNAFMRFNAIS------------------------------------------ Sc_TEP1 idl------------------------------------------------ET--RTLVEEETNNVICERIGWLDHFPPP-FELLEEIVDGIENYLSKNRVAVLHCRMGKGRSGMITVAYLMKYLQC-PLGEARLIFMQARFKygmtnGVTIPSQLRYLRYHEFFITHE