15 948 MTMR1 LTVTD---FKLYFKNVERD-----------------------PHFILDVPLGVISRVEKI-GAQSH-------------------------------------------------------------GDNS--CGIEIVCKDMRNLRLAYK-----------------------QEEQSKLGIFENLNKH-----AFPL-----------------------SNGQALFAFSYKEKFP----------------------------------------------------------------INGWKVY----------DPVSEYK--RQGLPN-ESWKIS-KINSNYEF-------CDTYPAI-----IVVPTSVK----DDD-LSKV--AAFRAKGRVPVLSWI-----------------HPESQATITRCSQPLVGPND-KEDEKYLQTIMDANAQSHKLIIFDAR-------------QNSV-ADTNKTKGGG--YESESAYPNAELVFLEI------------------HNIHVMRESLRKLKEIVYPSIDE----ARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKT------SVVVHCSDGW----------DRTAQLTSLAML----------MLD------SYYRTIKGFETL---VEKEWISFGHRFALRVGHGNDN----------HADADRSPIFLQFV--DCVWQMTRQFPSAFEFNEL----FLITIL------DHLYSCLFGTFLCNCEQQRFKE--DVYT---------------------KTISLWSYINSQ-----------------LDEFSNPFFVNYE-NHVLYPVA-SLSHLELWVN-----------------YYVRW-----NPRMR---------PQMPI-HQNLKE--------LLAVRAELQ--KRVEGLQREVATR MTMR2 LTVTN---YRLYFKSMERD-----------------------PPFVLDASLGVINRVEKIGGASSR-------------------------------------------------------------GENS--YGLETVCKDIRNLRFAHK-----------------------PEGRTRRSIFENLMKY-----AFPV-----------------------SNNLPLFAFEYKEVFP----------------------------------------------------------------ENGWKLY----------DPLLEYR--RQGIPN-ESWRIT-KINERYEL-------CDTYPAL-----LVVPANIP----DEE-LKRV--ASFRSRGRIPVLSWI-----------------HPESQATITRCSQPMVGVSG-KEDEKYLQAIMDSNAQSHKIFIFDAR-------------PSVN-AVANKAKGGG--YESEDAYQNAELVFLDI------------------HNIHVMRESLRKLKEIVYPNIEE----THWLSNLESTHWLEHIKLILAGALRIADKVESGKT------SVVVHCSDGW----------DRTAQLTSLAML----------MLD------GYYRTIRGFEVL---VEKEWLSFGHRFQLRVGHGDKN----------HADADRSPVFLQFI--DCVWQMTRQFPTAFEFNEY----FLITIL------DHLYSCLFGTFLCNSEQQRGKE--NLPK---------------------RTVSLWSYINSQ-----------------LEDFTNPLYGSYS-NHVLYPVA-SMRHLELWVG-----------------YYIRW-----NPRMK---------PQEPI-HNRYKE--------LLAKRAELQ--KKVEELQREISNR MTM1 VYITN---YRLYLRSLETD-----------------------SSLILDVPLGVISRIEKMGGATSR-------------------------------------------------------------GENS--YGLDITCKDMRNLRFALK-----------------------QEGHSRRDMFEILTRY-----AFPL-----------------------AHSLPLFAFLNEEKFN----------------------------------------------------------------VDGWTVY----------NPVEEYR--RQGLPN-HHWRIT-FINKCYEL-------CDTYPAL-----LVVPYRAS----DDD-LRRV--ATFRSRNRIPVLSWI-----------------HPENKTVIVRCSQPLVGMSG-KDDEKYLDVIRETNKQISKLTIYDAR-------------PSVN-AVANKATGGG--YESDDAYHNAELFFLDI------------------HNIHVMRESLKKVKDIVYPNVEE----SHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKS------SVLVHCSDGW----------DRTAQLTSLAML----------MLD------SFYRSIEGFEIL---VQKEWISFGHKFASRIGHGDKN----------HTDADRSPIFLQFI--DCVWQMSKQFPTAFEFNEQ----FLIIIL------DHLYSCRFGTFLFNCESARERQ--KVTE---------------------RTVSLWSLINSN-----------------KEKFKNPFYTKEI-NRVLYPVA-SMRHLELWVN-----------------YYIRW-----NPRIK--------QQQPNPVEQRYME--------LLALRDEYI--KRLEELQLANSAK MTMR10 LICSN---FKISFITDDPMPLQKFH-------------YRNLLLGEHDVPLTCIEQIVTVNDHKRKQ---------------------------------------------------KVLGPNQKLKFNP--TELIIYCKDFRIVRFRFD----------------------ESGPESAKKVCLAIAHY-----SQPT------------------------DLQLLFAFEYVGKKYHNSANKINGIPSGDGGGGGG-------------------------------GGNGAGGGSSQKTPLFETYS----------DWDREIK--RTGA---SGWRVC-SINEGYMI-------STCLPEY-----IVVPSSLA----DQD-LKIF--SHSFVGRRMPLWCWS-----------------HSN-GSALVRMALIKDVL---KIDQRICNAITKSHPQ-SDVYKSDLD--------------------------------------------KTL------------------PNIQEVQAAFVKLKQLCVNEETE----EKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHL------SVVLQEEEGR----------DLSCCVASLVQV----------MLD------PYFRTITGFQSL---IQKEWVMAGYQFLDRCNHLKR-------------SEKESPLFLLFL--DATWQLLEQYPAAFEFSET----YLAVLY------DSTRISLFGTFLFNSPHQRVKQ--STEFAISKNIQ-------LGDEKGLKFPSVWDWSLQFT-------------AKDRTLFHNPFYIGKSTHGVILPRV-SGTHIKLWKL-----------------CYFRW-----VPEAQ---------ISLGG----SIT--------AFHKLSLLADE--VDVLSRMLRQQ MTMR12 LVCTD---FKIAFLGDDESALDNDET-----------QFKNKVIGENDITLHCVDQIYGVFDEKKKT-------------------------------------------------------LFGQLKKYP--EKLIIHCKDLRVFQFCLR----------------------YTKEEEVKRIVSGIIHH-----TQAP-----------------------KLLKRLFLFSYATAAQNNTVTDPKN-----------------------------------------------------HTVMFDTLK----------DWCWELE--RTKGN--MKYKAV-SVNEGYKV-------CERLPAY-----FVVPTPLP----EEN-VQR------FQGHGIPIWCWS-----------------CHNGSALLKMSALPK------EQDDGILQIQKSFLD---GIYKTIHR-------------PPYE-IVKT-------------EDLSS--NFLSL------------------QEIQTAYSKFKQLFLIDNSTDTD----IKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNM------NVLLLEENAS----------DLCCLISSLVQL----------MMD------PHCRTRIGFQSL---IQKEWVMGGHCFLDRCNHLRQ------------NDKEEVPVFLLFL--DCVWQLVHQHPPAFEFTET----YLTVLS------DSLYIPIFSTFFFNSPHQKDTN--MGREGQDTQ----------SKPLNLLTVWDWSVQFEP---------------KAQTLLKNPLYVEKPKHGLLLPHI-EGPEIKVWAQ-----------------RYLRW-----IPEAQ---------ILGGG----QVA--------TLSKLLEMMEE--VQSLQEKIDER MTMR11 ---MP---PRVTFQPCGWQWNQD-----------------TPLNSEYDFALVNIGRLEAVSGLSRVQ----------------------------------------------------LLRPGSLHKFIP--EEILIHGRDFRLLRVGFEA---------------------GGLEPQAFQVTMAIVQA-----RAQS------------------------NQAQQYSGITLSKAGQGSGSRKP------------------------------------------------------PIPLMETAE----------DWETERK--KQAA---RGWRVS-TVNERFDV-------ATSLPRY-----FWVPNRIL----DSE-VRRA--FGHFHQGRGPRLSWH-----------------HPG-GSDLLRCGGFYTAS---KEDIRAVELMLQAGH--SDVVLVDTM--------------------------------------------DEL------------------PSLADVQLAHLRLRALCLPDVAE----DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVR------SVILQERGDR----------DLNGLLSSLVQL----------LSA------PEARTLFGFQSL---VQREWVAAGHPFLTRLGGTG--------------ASEEAPVFLLFL--DCVWQLLQQFPADFEFSEF----FLLALH------DSVRVPDTLTFLRNTPWERGKQ--SGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYS-------------NAQILQFQNPGYDPEHCPGLLLPGY-LGPQIRLWRR-----------------CYLRG-----RPEVQ---------MGLSA-----------------PTISGLQDE--LSHLQELLRKW MTMR14 -------------------------------------------------------------------------------------------------------------------------------------------ASSGNQPPQ-------------------------------ELGLGELLEEF-----SRTQ---------------------------------YRAKDGS------GTG--------------------------------------------------------GSKVE----------RIEKRCL--ELFG---RDYCFSVIPNTNGDI-------CGHYPRH-----IVFLEYESSEKEQDL-IHRSKMARCRGRFVCPVILFK---------------------GKHICRSATLAGWGELY-GDTHLFDKVRGYDIKLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQ-------------RYADFTLLSIPY------------------PGCE----FFKEYKDRDYMAHSL----NIDWSQYQ--CWD-LVQQTQNYLKLLLSLVNSDDD-----SGLLVHCISGW----------DRTPLFISLLRL----------SLWA---DGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEE-------------IFFFCFNFLKHITSEEFSALKTQRRKSLPARDG----GFTLED------ICMLRRKDRGSTTSLGS------------------------------------DFSLVMES-----------------SPGATGSFTYEAVE------------------SFPD-----------ELPN-------------------------------SCLLAA----------LSDRETR--LQEVRSA---- MTMR3 IALSN---YRLHIKFKE---------------------------SLVNVPLQLIESVECRDI-----------------------------------------------------------------------FQLHLTCKDCKVIRCQFS------------------------TFEQCQEWLKRLNNA-----IRPP-----------------------AKIEDLFSFAYHAWCMEVYASEKEQHG-------------------------------------------------DLCRPGEHVTS----------RFKNEVE--RMGF---NAWRIS-NINEKYKL-------CGSYPQE-----LIVPAWIT----DKE-LESV--SSFRSWKRIPAVIYR-----------------HQSNGAVIARCGQPEVSWWG-ADDEHLVQSVAKACASPQKLLILDAR-------------SYAA-AVANRAKGGG--CECPEYYPNCEVVFMGM------------------ANIHSIRRSFQSLRLLCTQMPDP----GNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQR------PVLVHCSDGW----------DRTPQIVALAKL----------LLD------PYYRTIEGFQVL---VEMEWLDFGHKFADRCGHGENS----------DDLNERCPVFLQWL--DCVHQLQRQFPCSFEFNEA----FLVKLV------QHTYSCLFGTFLCNNAKERGEK--HTQE---------------------RTCSVWSLLRAG-----------------NKAFKNLLYSSQS-EAVLYPVC-HVRNLMLWSA-----------------VYLPC-----PSPTT---------PVDDS-CAPYPA--------PGTSPDDPPLSKQVQELKSRLESQ MTMR4 IAISN---YRLHIKFKD---------------------------SVINVPLRMIDSVESRDM-----------------------------------------------------------------------FQLHISCKDSKVVRCHFS------------------------TFKQCQEWLSRLSRA-----TARP-----------------------AKPEDLFAFAYHAWCLGL--TEEDQHT-------------------------------------------------HLCQPGEHIRC----------RQEAELA--RMGF---NVWRVS-HINSNYKL-------CPSYPQK-----LLVPVWIT----DKE-LENV--ASFRSWKRIPVVVYR-----------------HLRNGAAIARCSQPEISWWG-ADDEYLVTSIAKACALPQKLLILDAR-------------SYTA-AVANRAKGGG--CECEEYYPNCEVVFMGM------------------ANIHAIRNSFQYLRAVCSQMPDP----SNWLSALESTKWLQHLSVMLKAAVLVANTVDREGR------PVLVHCSDGW----------DRTPQIVALAKI----------LLD------PYYRTLEGFQVL---VESDWLDFGHKFGDRCGHQENV----------EDQNEQCPVFLQWL--DSVHQLLKQFPCLFEFNEA----FLVKLV------QHTYSCLYGTFLANNPCEREKR--NIYK---------------------RTCSVWALLRAG-----------------NKNFHNFLYTPSS-DMVLHPVC-HVRALHLWTA-----------------VYLPA-----SSPCT---------LGEEN-MDLYLS--------PVAQSQERSLDRQVRELQMRLDIR MTMR8 LYLTA---THLIYVEASGAA-----------------------RKETWIALHHIATVEKLPITSLG-------------------------------------------------------------------CPLTLRCKNFRVAHFVLD------------------------SDLVCHEVYISLLKL-----SQPA------------------------LPEDLYAFSYNPKSSKEM------------------------------------------------------------RESGWKLI----------DPISDFG--RMGIPN-RNWTIT-DANRNYEI-------CSTYPPE-----IVVPKSVT----LGT-VVGS--SKFRSKERVPVLSYL-----------------YKENNAAICRCSQPLSGFY--VDDELLLEAISQTNPGSQFMYVVDTR-------------PKLN-AMANRAAGKG--YENEDNYANIRFRFMGI------------------ENIHVMRSSLQKLLEVCELKPTM----SEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKA------SVLVHCSDGW----------DRTAQVCSVASI----------LLD------PFYRTFKGLMIL---IEKEWISMGHKFSQRCGHLDG------------DSKEVSPIFTQFL--DCIWQLMEQFPCAFEFNEN----FLLEIH------DHVFSCQFGNFLGNCQKDREDL--RVYE---------------------KTHSVWPFLVQR-----------------KPDFRNPLYKGFTMYGVLNPST-VPYNIQFWCG-----------------MYNRF-----DKGLQ---------PKQSM-LESLLE--------IKKQRAMLET--DVHELEKKLKVR MTMR6 LYLTA---THLLFIDSH--------------------------QKETWILHHHIASVEKLALTTSG-------------------------------------------------------------------CPLVIQCKNFRTVHFIVP------------------------RERDCHDIYNSLLQL-----SKQA------------------------KYEDLYAFSYNPKQNDSE------------------------------------------------------------RLQGWQLI----------DLAEEYK--RMGVPN-SHWQLS-DANRDYKI-------CETYPRE-----LYVPRIAS----KPI-IVGS--SKFRSKGRFPVLSYY-----------------HQDKEAAICRCSQPLSGFS--LEDEHLLQAISKANPVNRYMYVMDTR-------------PKLN-AMANRAAGKG--YENEDNYSNIRFQFVGI------------------ENIHVMRSSLQKLLEVNGTKLSV----NDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENA------SVLVHCSDGW----------DRTSQVCSLGSL----------LLD------SYYRTIKGFMVL---IEKDWISFGHKFSERCGQLDG------------DPKEVSPVFTQFL--ECVWHLTEQFPQAFEFSEA----FLLQIH------EHIHSCQFGNFLGNCQKEREEL--KLKE---------------------KTYSLWPFLLED-----------------QKKYLNPLYSSESHFTVLEPNT-VSFNFKFWRN-----------------MYHQF-----DRTLH---------PRQSV-FNIIMN--------MNEQNKQLEK--DIKDLESKIKQR MTMR7 LYLTA---THVIFVENSPDP-----------------------RKETWILHSQISTIEKQATTATG-------------------------------------------------------------------CPLLIRCKNFQIIQLIIP------------------------QERDCHDVYISLIRL-----ARPV------------------------KYEELYCFSFNPMLDKEE------------------------------------------------------------REQGWVLI----------DLSEEYT--RMGLPN-HYWQLS-DVNRDYRV-------CDSYPTE-----LYVPKSAT----AHI-IVGS--SKFRSRRRFPVLSYY-----------------YKDNHASICRSSQPLSGFS--LEDEQMLQAIRKANPGSDFVYVVDTR-------------PKLN-AMANRAAGKG--YENEDNYSNIKFQFIGI------------------ENIHVMRNSLQKMLEVCELKPSM----SDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGA------SVLVHCSDGW----------DRTAQVCSVASL----------LLD------PHYRTLKGFMVL---IEKDWISFGHKFNHRYGNLDG------------DPKEISPVIDQFI--ECVWQLMEQFPCAFEFNER----FLIHIQ------HHIYSCQFGNFLCNSQKERREL--KIQE---------------------RTYSLWAHLWKN-----------------RADYLNPLFRADHSGTLHLPTTPCNFMYKFWSG-----------------MYNRF-----EKGMQ---------PRQSV-TDYLMA--------VKEETQQLEE--ELEALEERLEKI MTMR9 LCLTG---HHLILSSRQDN------------------------TEELWLLHSNIDAIDKRFV------------------------------------------------------------------GSL--GTIIIKCKDFRIIQLDIP------------------------GMEECLNIASSIEAL-----STLD------------------------SITLMYPFFYRPMFEV--------------------------------------------------------------IEDGWHSF----------LPEQEFELYSSAT---SEWRLS-YVNKEFAV-------CPSYPPI-----VTVPKSID----DEA-LRKV--ATFRHGGRFPVLSYY-----------------HKKNGMVIMRSGQPLTGTNG-KEDEKLINATLRAG---KRGYIIDTR-------------SLNV-AQQTRAKGGG--FEQEAHYPQWRRIHKSI------------------ERYHILQESLIKLVEACNDQHNM----DRWLSKLEASNWLTHIKEILTTACLAAQCIDREGA------SILIHGTEGT----------DSTLQVTSLAQI----------ILE------PRSRTIRGFEAL---IEREWLQAGHPFQQRCAQSAYC---------NTKQKWEAPVFLLFL--DCVWQILRQFPCSFEFNEN----FLIMLF------EHAYASQFGTFLGNNESERCKL--KLQQ---------------------KTMSLWSWVNQP---------------SELSKFTNPLFEAN--NLVIWPSV-APQSLPLWEG-----------------IFLRW-----NRSSK---------YLDEA-YEEMVN--------IIEYNKELQAK--VNILRRQLAEL SBF1 AVLTD----------INSER-------------------------HYCACLTFWEPAEPSQETTRVEDATER-----------------------------------------EEEGDEGGQTHLSPTAPA--PSAQLFAPKTLVLVSRLD------------------------HTEVFRNSLGLIYAI-----HVEG-------------------------------------------------------------------------------------------------------LNVCLEN----------VIGNLLT---CTVPLAGGSQRTISLGAG-DRQVIQTPLADSLPVSRCSVALLFRQLGITNV-----LSLF--CAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPA------------QLLEVLSTPTP-----FIIGVN-------------AAFQAETQ--------------ELLDVIVADLDGGTVTIPEC--VHIPPLPEPLQSQTHSVLSMVLDPELELTSS----LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPE------PVIRFHKAAFLGQRGVNSARRLEVVRNCISYVFE------GKMLEAKKLLPAVLRALKGRAA--------RRCLAQELHLHVQQNRAVL-----------DHQQFDFVVRMM--NCCLQDCTSL---DEHGIAAALLPLVTAF------CRKLSPGVTQFAYSCVQEHVVW---------------------------STPQFWEAMFYG---------------DVQ-THIRALYLEPTENSMAGSVA-ESYD-TESGFEDAETCD---VAGAVVRFINRF-----VDKVC---------TESGVT---SDHLKGL-HVMVPDIVQMHIET--LEAVQRESRRL SBF2 VVLTD----------IDSDR-------------------------HYCSCLTFYE-AEINLQGTKKEEIE----------------------------------------------GEAKVSGLIQP--------AEVFAPKSLVLVSRLY------------------------YPEIFRACLGLIYTV-----YVDS-------------------------------------------------------------------------------------------------------LNVSLES----------LIANLCA---CLVPAAGGSQKLFSLGAG-DRQLIQTPLHDSLPITGTSVALLFQQLGIQNV-----LSLF--CAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPA------------QLLEVLSSPTP-----FIIGVH-------------SVFKTDVH--------------ELLDVIIADLDGGTIKIPEC--IHLSSLPEPLLHQTQSALSLILHPDLEVLSH----SKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAE------PVIHFHKTAFLGQRGFNSAQRLEVVRNCISFIFE------NKILETEKTLPAALRALKGKAA--------RQCLTDELGLHVQQNRAIL-----------DHQQFDYIIRMM--NCTLQDCSSL---EEYNIAAALLPLTSAF------YRKLAPGVSQFAYTCVQDHPIW---------------------------TNQQFWETTFYN---------------AVQ-EQVRSLYLSAKENSIAGSVA-ESYD-TESGFEDSENTD---IANSVVRFITRF-----IDKVC---------TESGVT---QDHIKSL-HCMIPGIVAMHIET--LEAVHRESRRL