49 296 PTPN1 NKNRNRYRDVSPFDHSRIKLHQ---------------ED--------NDYINASLIK------MEEAQ----RSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSL-KCAQYWPQKEEKEMIFEDTNLKLTLISEDIK-SYYTVRQLELENLT-----------TQETREILHFHYTTWPDFGVP--ESPASFLNFLFKVRESGSLSPEHG-----------PVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE PTPN2 NRNRNRYRDVSPYDHSRVKLQN---------------AE--------NDYINASLVD------IEEAQ----RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESV-KCAQYWP-TDDQEMLFKETGFSVKLLSEDVK-SYYTVHLLQLENIN-----------SGETRTISHFHYTTWPDFGVP--ESPASFLNFLFKVRESGSLNPDHG-----------PAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE PTPN3 NLDKNRYKDVLPYDTTRVLLQ----------------GN--------EDYINASYVN------MEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT-KCHQYWPDP---PDVMNHGGFHIQCQSEDCT-IAYVSREMLVTNTQ-----------TGEEHTVTHLQYVAWPDHGVP--DDSSDFLEFVNYVRSLRVD--------------SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR PTPN4 NISKNRYRDISPYDATRVILK----------------GN--------EDYINANYIN------MEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRV-KCHQYWPEP---TGSSSYGCYQVTCHSEEGN-TAYIFRKMTLFNQE-----------KNESRPLTQIQYIAWPDHGVP--DDSSDFLDFVCHVRNKRAGK-------------EEPVVVHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK PTPN5 LVRKNRYKTILPNPHSRVCLTSPDPD-----------DPL-------SSYINANYIR------GYGGEEK---VYIATQGPIVSTVADFWRMVWQEHTPIIVMIT-NIEEMNE-KCTEYWP---EE--QVAYDGVEITVQKVIHT-EDYRLRLISLK-------------SGTEERGLKHYWFTSWPDQKTP--DRAPPLLHLVREVEEAAQQEGPH----------CAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL PTPN6 NKGKNRYKNILPFDHSRVILQGRDSN-----------IPG-------SDYINANYIKNQLL--GPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN-KCVPYWP---EVGMQRAYGPYSVTNCGEHDT-TEYKLRTLQVSPL----------DNGDLIREIWHYQYLSWPDHGVP--SEPGGVLSFLDQINQRQ-ESLPH----------AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ PTPN7 HASKDRYKTILPNPQSRVCLGRAQSQ-----------ED--------GDYINANYIR------GYDGKEK---VYIATQGPMPNTVSDFWEMVWQEEVSLIVMLT-QLREGKE-KCVHYWP---TE--EETYGPFQIRIQDMKEC-PEYTVRQLTIQ-------------YQEERRSVKHILFSAWPDHQTP--ESAGPLLRLVAEVEESP-ETAAH----------PGPIVVHCSAGIGRTGCFIATRIGCQQLKARGE---VDILGIVCQLRLDRGGMIQTAEQYQFLHHTLAL PTPN9 NLEKNRYGDVPCLDQTRVKLTKRSGH-----------TQ--------TDYINASFMD------GYKQK----NAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRR-KCGQYWPLEKDSRIRFG--FLTVTNLGVENM-NHYKKTTLEIHNTE-----------ERQKRQVTHFQFLSWPDYGVP--SSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE PTPN11 NKNKNRYKNILPFDHTRVVLHDGDPN-----------EPV-------SDYINANIIMPEFE--TKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKS-KCVKYWP---DEYALKEYGVMRVRNVKESAA-HDYTLRELKLSKV----------GQGNTERTVWQYHFRTWPDHGVP--SDPGGVLDFLEEVHHKQ-ESIMD----------AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQH PTPN12 NVKKNRYKDILPFDHSRVKLTLKTPS-----------QD--------SDYINANFIK------GVYGP----KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRK-KCERYWP--LYGEDPITFAPFKISCEDEQAR-TDYFIRTLLLEFQ-------------NESRRLYQFHYVNWPDHDVP--SSFDSILDMISLMRKYQEHE-------------DVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ PTPN13 NRRKNRYKNILPYDATRVPLG----------------DE--------GGYINASFIK------IPVGK--EEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI-KCQRYWPNILGKTTMVSN-RLRLALVRMQQL-KGFVVRAMTLEDIQ-----------TREVRHISHLNFTAWPDHDTP--SQPDDLLTFISYMRHIHRSG---------------PIITHCSAGIGRSGTLICIDVVLGLISQDLD---FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY PTPN14 NAERSRIREVVPYEENRVELIPTK-E-----------NN--------TGYINASHIK------VVVGG--AEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT-KSHRYWPKLGSKHSSATYGKFKVTTKFRTDS-VCYATTGLKVKHLL-----------SGQERTVWHLQYTDWPDHGCP--EDVQGFLSYLEEIQSVRRHTNSMLEG---TKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK---VEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ PTPN18 NVRKNRYKDVLPYDQTRVILSLLQEE-----------GH--------SDYINGNFIR------GVDGS----LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRK-RCERYWA--QEQE-PLQTGLFCITLIKEKWLNEDIMLRTLKVTFQ-------------KESRSVYQLQYMSWPDRGVP--SSPDHMLAMVEEARRLQGSG-------------PEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ PTPN20 NREKNRYRDILPYDSTRVPLG----------------KS--------KDYINASYIR------IVNCG--EEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII-KCYHYWP-ISLKKPLELK-HFRVFLENYQIL-QYFIIRMFQVVEKS-----------TGTSHSVKQLQFTKWPDHGTP--ASADSFIKYIRYARKSHLTG---------------PMVVHCSAGIGRTGVFLCVDVVFCAIVKNCS---FNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE PTPN21 NAERNRFQDVLPYDDVRVELVPTK-E-----------NN--------TGYINASHIK------VSVSG--IEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGRE-KSFRYWPRLGSRHNTVTYGRFKITTRFRTDS-GCYATTGLKMKHLL-----------TGQERTVWHLQYTDWPEHGCP--EDLKGFLSYLEEIQSVRRHTNSTSD----PQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ PTPN22 NIKKNRYKDILPYDYSRVELSLITSD-----------ED--------SSYINANFIK------GVYGP----KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKK-KCERYWA--EPGEMQLEFGPFSVSCEAEKRK-SDYIIRTLKVKFN-------------SETRTIYQFHYKNWPDHDVP--SSIDPILELIWDVRCYQEDD-------------SVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE PTPN23 YSLKNRHQDVMPYDSNRVVLRS---------------GK--------DDYINASCVE------GLSPYC---PPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQ-KVARYFPTERGQPMVHG--ALSLALSSVRST-ETHVERVLSLQFRD-----------QSLKRSLVHLHFPTWPELGLP--DSPSNLLRFIQEVH-AHYLHQRPL---------HTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNG--IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR PTPRA-D1 NKEKNRYVNILPYDHSRVHLTPVEGV-----------PD--------SDYINASFIN------GYQEKNK----FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEC-KCAQYWP----DQGCWTYGNIRVSVEDVTVL-VDYTVRKFCIQQVGDM-------TNRKPQRLITQFHFTSWPDFGVP--FTPIGMLKFLKKVKACN-PQY------------AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE PTPRA-D2 NMKKNRVLQIIPYEFNRVIIPVKRGE---------ENTD----------YVNASFID------GYRQKDS----YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQE-KCAQYWPS----DGLVSYGDITVELKKEEEC-ESYTVRDLLVTNTR-----------ENKSRQIRQFHFHGWPEVGIP--SDGKGMISIIAAVQKQQQQSG------------NHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE PTPRB NRGKNRYNNILPYDATRVKLSNVDDD-----------PC--------SDYINASYIP------GNNFRRE----YIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRV-KCDHYWP---ADQDSLYYGDLILQMLSESVL-PEWTIREFKICGE----------EQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYI-NRSPG----------AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDS---VDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD PTPRC-D1 NQNKNRYVDILPYDYNRVELSEINGD-----------AG--------SNYINASYID------GFKEPRK----YIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPS--MEEGTRAFGDVVVKINQHKRC-PDYIIQKLNIVNK----------KEKATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFS-NFF------------SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK---VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE PTPRC-D2 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEV----MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWG-----EGKQTYGDIEVDLKDTDKS-STYTLRVFELRHSK-----------RKDSRTVYQYQYTNWSVEQLP--AEPKELISMIQVVKQKLPQKNSSEGN---KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEV---VDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS PTPRD-D1 NKPKNRYANVIAYDHSRVLLSAIEGI-----------PG--------SDYVNANYID------GYRKQNA----YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV-KCDQYWP----SRGTETHGLVQVTLLDTVEL-ATYCVRTFALYK-----------NGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCN-PPD------------AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE PTPRD-D2 NKFKNRLVNIMPYESTRVCLQPIRGV---------EGSD----------YINASFID------GYRQQKA----YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPA----ERSARYQYFVVDPMAEYNM-PQYILREFKVTDAR-----------DGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQ-----------DGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE PTPRE-D1 NREKNRYPNILPNDHSRVILSQLDGI-----------PC--------SDYINASYID------GYKEKNK----FIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEE-KCHQYWP----DQGCWTYGNIRVCVEDCVVL-VDYTIRKFCIQPQLPD-------GCKAP-RLVSQLHFTSWPDFGVP--FTPIGMLKFLKKVKTLN-PVH------------AGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE PTPRE-D2 NMKKARVIQIIPYDFNRVILSMKRGQ---------EYTD----------YINASFID------GYRQKDY----FIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQD-KCYQYWPT----EGSVTHGEITIEIKNDTLS-EAISIRDFLVTLNQPQA------RQEEQVRVVRQFHFHGWPEIGIP--AEGKGMIDLIAAVQKQQQQTG------------NHPITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD PTPRF-D1 NKPKNRYANVIAYDHSRVILTSIDGV-----------PG--------SDYINANYID------GYRKQNA----YIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRV-KCDQYWP----ARGTETCGLIQVTLLDTVEL-ATYTVRTFALHK-----------SGSSEKRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACN-PLD------------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE PTPRF-D2 NKFKNRLVNIMPYELTRVCLQPIRGV---------EGSD----------YINASFLD------GYRQQKA----YIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPA----ERSARYQYFVVDPMAEYNM-PQYILREFKVTDAR-----------DGQSRTIRQFQFTDWPEQGVP--KTGEGFIDFIGQVHKTKEQFGQ-----------DGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE PTPRG-D1 NKHKNRYINILAYDHSRVKLRPLPGK-----------DSKH------SDYINANYVD------GYNKAKA----YIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRR-KCDQYWP----TENSEEYGNIIVTLKSTKIH-ACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP--EYALPVLTFVRRSSAAR-MPE------------TGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE PTPRG-D2 NKEKNRNSSVVPSERARVGLAPLPGM-------------------KGTDYINASYIM------GYYRSNE----FIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED--EFVYWPS---REESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEAT-------QDDYVLEVRHFQCPKWPNP-DAP-ISST-----FELINVIKEEALT----------RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS PTPRH NNAKNRYRNVLPYDWSRVPLKPIHEE-----------PG--------SDYINASFMP------GLWSPQE----FIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRV-KCEHYWPL--DSQPC-THGHLRVTLVGEEVM-ENWTVRELLLLQ-----------VEEQKTLSVRQFHYQAWPDHGVP--SSPDTLLAFWRMLRQWL-DQTME----------GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGL---LGPFSFVRKMRESRPLMVQTEAQYVFLHQCILR PTPRJ NRGKNRYNNVLPYDISRVKLS-VQTH-----------ST--------DDYINANYMP------GYHSKKD----FIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRT-KCEEYWP---SKQ-AQDYGDITVAMTSEIVL-PEWTIRDFTVKNI----------QTSESH-PLRQFHFTSWPDHGVP--DTTDLLINFRYLVRDYM-KQSPP----------ESPILVHCSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD PTPRK-D1 NRAKNRYGNIIAYDHSRVILQPVEDD-----------PS--------SDYINANYIDIWLYRDGYQRPSH----YIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRV-KCYKYWP----D-DTEVYGDFKVTCVEMEPL-AEYVVRTFTLER-----------RGYNEIREVKQFHFTGWPDHGVP--YHATGLLSFIRRVKLSN-PPS------------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYIFIHDAILE PTPRK-D2 NHDKNRFMDMLPPDRCLPFLITIDG--------------------ESSNYINAALMD------SYRQPAA----FIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ---GCPQYWP----EEGMLRYGPIQVECMSCS---MDCDVINRIFRICNLTR-------PQEGYLMVQQFQYLGWASHREVP-GSKRSFLKLILQVEKWQEECEE----------GEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE PTPRM-D1 NRMKNRYGNIIAYDHSRVRLQTIEGD-----------TN--------SDYINGNYID------GYHRPNH----YIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRV-KCCKYWP----D-DTEIYKDIKVTLIETELL-AEYVIRTFAVEK-----------RGVHEIREIRQFHFTGWPDHGVP--YHATGLLGFVRQVKSKS-PPS------------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE PTPRM-D2 NHEKNRCMDILPPDRCLPFLITIDG--------------------ESSNYINAALMD------SYKQPSA----FIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ---LCPQYWP----ENGVHRHGPIQVEFVSAD---LEEDIISRIFRIYNAAR-------PQDGYRMVQQFQFLGWPMYRDTP-VSKRSFLKLIRQVDKWQEEYNG----------GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE PTPRN NIKKNRHPDFLPYDHARIKLKVESSP-----------SR--------SDYINASPII------EHDPRM---PAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK-QCDRYWPDE-GASLYHV--YEVNLVSEHIWC-EDFLVRSFYLKNVQ-----------TQETRTLTQFHFLSWPAEGTP--ASTRPLLDFRRKVN-KCYRGR------------SCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK--EIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE PTPRN2 NVPKNRSLAVLTYDHSRVLLKAENSH-----------SH--------SDYINASPIM------DHDPRN---PAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVR-QCYHYWPDE-GSNLYHI--YEVNLVSEHIWC-EDFLVRSFYLKNLQ-----------TNETRTVTQFHFLSWYDRGVP--SSSRSLLDFRRKVN-KCYRGR------------SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAK--EIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE PTPRO NRCKNRYTNILPYDFSRVRLVSMNEE-----------EG--------ADYINANYIP------GYNSPQE----YIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRV-KCDHYWPF--TEEPI-AYGDITVEMISEEEQ-DDWACRHFRIN-------------YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQA-TKS------------KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL PTPRQ NRAKNRFPNIKPYNNNRVKLIADASV-----------PG--------SDYINASYIS------GYLCPNE----FIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRI-RCHQYWPE--DNKPVTVFGDIVITKLMEDVQ-IDWTIRDLKIE-------------RHGDCMTVRQCNFTAWPEHGVP-ENSAP-LIHFVKLVRASR-AHD------------TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILD PTPRR HGTKNRYKTILPNPLSRVCLRPKNVT-----------DSL-------STYINANYIR------GYSGKEK---AFIATQGPMINTVDDFWQMVWQEDSPVIVMIT-KLKEKNE-KCVLYWP---EK--RGIYGKVEVLVISVNEC-DNYTIRNLVLK-------------QGSHTQHVKHYWYTSWPDHKTP--DSAQPLLQLMLDVEEDR-LASQG----------RGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL PTPRS-D1 NKPKNRYANVIAYDHSRVILQPIEGI-----------MG--------SDYINANYVD------GYRCQNA----YIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI-KCDQYWP----NRGTETYGFIQVTLLDTIEL-ATFCVRTFSLHK-----------NGSSEKREVRQFQFTAWPDHGVP--EYPTPFLAFLRRVKTCN-PPD------------AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE PTPRS-D2 NKFKNRLVNIMPYESTRVCLQPIRGV---------EGSD----------YINASFID------GYRQQKA----YIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYWPA----ERSARYQYFVVDPMAEYNM-PQYILREFKVTDAR-----------DGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQ-----------DGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE PTPRT-D1 NRNKNRYGNIISYDHSRVRLLVLDGD-----------PH--------SDYINANYID------GYHRPRH----YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRV-KCVRYWP----D-DTEVYGDIKVTLIETEPL-AEYVIRTFTVQK-----------KGYHEIRELRLFHFTSWPDHGVP--CYATGLLGFVRQVKFLN-PPE------------AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE PTPRT-D2 NHDKNRSMDVLPLDRCLPFLISVDG--------------------ESSNYINAALMD------SHKQPAA----FVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ---FCMQYWP----EKTSGCYGPIQVEFVSAD---IDEDIIHRIFRICNMAR-------PQDGYRIVQHLQYIGWPAYRDTP-PSKRSLLKVVRRLEKWQEQYDG----------REGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE PTPRU-D1 KVKGSRQEPMPAYDRHRVKLHPMLGD-----------PN--------ADYINANYID------GYHRSNH----FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV-KCSRYWP----E-DSDTYGDIKIMLVKTETL-AEYVVRTFALER-----------RGYSARHEVRQFHFTAWPEHGVP--YHATGLLAFIRRVKAST-PPD------------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE PTPRU-D2 NRDKNRSMDVLPPDRCLPFLISTDG--------------------DSNNYINAALTD------SYTRSAA----FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP----EPGRQQYGLMEVEFMSGT---ADEDLVARVFRVQNISR-------LQEGHLLVRHFQFLRWSAYRDTP-DSKKAFLHLLAEVDKWQAES------------GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNL---VDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE PTPRZ1-D1 NKHKNRYINIVAYDHSRVKLAQLAEK-----------DGKL------TDYINANYVD------GYNRPKA----YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRR-KCDQYWP----ADGSEEYGNFLVTQKSVQVL-AYYTVRNFTLRNTKIKKGSQ---KGRPSGRVVTQYHYTQWPDMGVP--EYSLPVLTFVRKAAYAK-RHA------------VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE PTPRZ1-D2 NREKNRTSSIIPVERSRVGISSLSG--------------------EGTDYINASYIM------GYYQSNE----FIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED--EFVYWPN---KDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEAT-------QDDYVLEVRHFQCPKWPNP-DSP-ISKT-----FELISVIKEEAAN----------RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILS