Biological Significance of Phosphorylation

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Phosphorylation regulates protein folding. 4E binding proteins (4E-BPs) play an important role in the regulation of translation by binding to eukaryotic translation initiation factor 4E (eIF4E) and inhibiting assembly of the eIF4F complex. Phosphorylation of 4E-BPs results in a disorder-to-order transition, bringing them from their binding-competent disordered state to a folded state incompatible with eIF4E binding [1].


  1. Metskas LA and Rhoades E. Folding upon phosphorylation: translational regulation by a disorder-to-order transition. Trends Biochem Sci. 2015 May;40(5):243-4. DOI:10.1016/j.tibs.2015.02.007 | PubMed ID:25769422 | HubMed [Metskas15]