Phosphatase Family AP - Revision history

Gerard at 23:07, 14 May 2016

2016-05-14T23:07:22Z

Mark at 19:04, 3 June 2015

2015-06-03T19:04:27Z

Mark: /* Evolution */

2015-01-05T15:46:57Z

‎Evolution

Mark at 04:58, 4 January 2015

2015-01-04T04:58:39Z

Mark: Created page with "Phosphatase Classification: Fold AP: Superfamily AP: Family AP..."

2014-12-30T21:01:44Z

Created page with "Phosphatase Classification: Fold AP: Superfamily AP: Family AP..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_AP|Fold AP]]: [[Phosphatase_Superfamily_AP|Superfamily AP]]: [[Phosphatase_Family_AP|Family AP]] (Alkaline phosphatase)

Alkaline phosphatases are a superfamily ([http://pfam.xfam.org/family/PF00245 Pfam]) with a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear.

Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold ([http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bah.A.html SCOP]), which contains other enzymes, such as phosphoesterases and sulfatases.

It has a single [[Phosphatase_Subfamily_AP|subfamily AP]].

===References===
<biblio>
#Swarup pmid=6167574
#Telfer pmid=8396040
#Chan pmid=3011792
</biblio>

← Older revision		Revision as of 19:04, 3 June 2015
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_AP\|Fold AP]]: [[Phosphatase_Superfamily_AP\|Superfamily AP]]: [[Phosphatase_Family_AP\|Family AP]] (Alkaline phosphatase)		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_AP\|Fold AP]]: [[Phosphatase_Superfamily_AP\|Superfamily AP]]: [[Phosphatase_Family_AP\|Family AP]] (Alkaline phosphatase)

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_AP|Fold AP]]: [[Phosphatase_Superfamily_AP|Superfamily AP]]:  [[Phosphatase_Family_AP|Family AP]] (Alkaline phosphatase)
 === Evolution ===
 Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold ([http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bah.A.html SCOP]), which contains other enzymes, such as phosphoesterases and sulfatases.
 === Functions ===

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_AP|Fold AP]]: [[Phosphatase_Superfamily_AP|Superfamily AP]]:  [[Phosphatase_Family_AP|Family AP]] (Alkaline phosphatase)
-Alkaline phosphatase is a conserved phosphatase that has a broad of substrates, including proteins. It is used in [http://labtestsonline.org/understanding/analytes/alp/tab/test/ clinical lab test], [http://en.wikipedia.org/wiki/Alkaline_phosphatase diary industry and biomedical research].
+Alkaline phosphatase is a conserved phosphatase that has a broad of substrates, including proteins. This family consists of a single subfamily, also called  [[Phosphatase_Subfamily_AP|AP]].
-−
-=== Evolution ===
-Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold ([http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bah.A.html SCOP]), which contains other enzymes, such as phosphoesterases and sulfatases.
-−
-=== Functions ===
-Alkaline phosphatases are a superfamily ([http://pfam.xfam.org/family/PF00245 Pfam]) with a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear.
-−
-=== Subfamily ===
-It has a single [[Phosphatase_Subfamily_AP|subfamily AP]].
-−
-===References===
-<biblio>
-#Swarup pmid=6167574
-#Telfer pmid=8396040
-#Chan pmid=3011792
-</biblio>