Phosphatase Family HP1 - Revision history

Gerard at 21:54, 25 October 2016

2016-10-25T21:54:22Z

2016-10-25T21:52:39Z

2016-10-25T21:52:07Z

2016-05-15T16:52:40Z

‎PFKFB

2016-05-15T16:39:09Z

‎HP1LE

2016-05-09T03:40:34Z

‎STS (TULA or UBASH3): tyrosine phosphatase

2016-05-09T03:40:02Z

‎TIGAR: TP53 Induced Glycolysis and Apoptosis Regulatory phosphatase

2016-05-09T03:38:41Z

2016-05-09T03:38:17Z

2016-05-09T03:37:51Z

← Older revision		Revision as of 21:54, 25 October 2016
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−	HP1 ~~has~~ two protein phosphatase subfamilies: PGAM5 is a serine phosphatase and STS (TULA or UBASH3) is a tyrosine phosphatase.	+	HP1 is one of two major families within the Histidine Phosphatase fold, that uses a pHis intermediate during catalysis. HP1 includes several non-protein phosphatases, and two protein phosphatase subfamilies: PGAM5 is a serine phosphatase and STS (TULA or UBASH3) is a tyrosine phosphatase.

	=== Subfamilies found in human ===		=== Subfamilies found in human ===

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]]:  [[Phosphatase_Family_HP1|HP, branch1 family]]
-The HP1 family has two protein phosphatase subfamilies: PGAM5 is a serine phosphatase and STS (TULA or UBASH3) is a tyrosine phosphatase.
 === Subfamilies found in human ===

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase):  [[Phosphatase_Family_HP1|HP, branch1 family]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]]:  [[Phosphatase_Family_HP1|HP, branch1 family]]
 The HP1 family has two protein phosphatase subfamilies: PGAM5 is a serine phosphatase and STS (TULA or UBASH3) is a tyrosine phosphatase.

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 ======[[Phosphatase_Subfamily_PFKFB|PFKFB]]======
-PFKFB is a bifunctional enzyme responsible for the synthesis (as kinase) and degradation (as phosphatase) of [[Phosphatase_Glossary#Fructose-2.2C6-bisphosphatase|fructose-2,6-bisphosphate]] a metabolite that controls glycolysis. Its two opposite enzymatic activities are encoded in two separate domains, N-terminal kinase domain and C-terminal phosphatase domain. PFKFB is found in most eukaryotes, often multiple copies per genome (human has four copies with different tissue expression). It emerged by gene fusion of the ancestors of the gene containing kinase domain and that containing phosphatase domain.
+PFKFB is a bifunctional enzyme responsible for the synthesis (as kinase) and degradation (as phosphatase) of [[Phosphatase_Glossary#Fructose-2.2C6-bisphosphatase|fructose-2,6-bisphosphate]] a glycolytic regulator.
 === Other subfamilies ===

← Older revision		Revision as of 16:39, 15 May 2016
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	======[[Phosphatase_Subfamily_HP1LE\|HP1LE]]======		======[[Phosphatase_Subfamily_HP1LE\|HP1LE]]======
−	HP1LE subfamily is found in choanoflagellates and sponge, but is absent from ~~eumetazoan~~. Its function is unclear.	+	HP1LE subfamily is found in choanoflagellates and sponge, but is absent from eumetazoa. Its function is unclear.

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 ======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3): tyrosine phosphatase ======
-STS is a protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoa, but ''C. elegans'' lost the signature domains, SH3 and H2 domain, which are common among STSs.
+STS is a protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates the Syk subfamily kinases Syk and ZAP-70. STS is conserved in metazoa, but ''C. elegans'' lost the signature domains, SH3 and H2 domain, which are common among STSs.
 ======[[Phosphatase_Subfamily_PFKFB|PFKFB]]======

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 ======[[Phosphatase_Subfamily_TIGAR|TIGAR]]: TP53 Induced Glycolysis and Apoptosis Regulatory phosphatase======
-TIGAR inhibits glycolysis and negatively modulates the level of intracellular reactive oxygen species (ROS), therefore regulating autophagy and apoptosis. TIGAR is found in chordates some basal [[Phosphatase_Glossary#Eumetazoa|eumetazoan]], but is absent from nematodes and arthropoda.
+TIGAR inhibits glycolysis and negatively modulates the level of intracellular reactive oxygen species (ROS), therefore regulating autophagy and apoptosis. TIGAR is found in chordates some basal [[Phosphatase_Glossary#Eumetazoa|eumetazoa]], but is absent from nematodes and arthropods.
 ======[[Phosphatase_Subfamily_STS|STS]] (TULA or UBASH3): tyrosine phosphatase ======

← Older revision		Revision as of 03:37, 9 May 2016
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HP\|Fold HP]]: [[Phosphatase_Superfamily_HP\|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP1\|HP, branch1 family]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_HP\|Fold HP]]: [[Phosphatase_Superfamily_HP\|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP1\|HP, branch1 family]]