Phosphatase Family PTEN - Revision history

Gerard at 18:56, 4 May 2018

2018-05-04T18:56:24Z

Gerard at 18:52, 4 May 2018

2018-05-04T18:52:02Z

Gerard at 21:39, 7 April 2015

2015-04-07T21:39:45Z

Gerard at 18:43, 30 December 2014

2014-12-30T18:43:31Z

Mark at 05:48, 29 December 2014

2014-12-29T05:48:29Z

Gerard at 04:08, 29 December 2014

2014-12-29T04:08:26Z

Gerard: /* Auxlin subfamily */

2014-12-28T06:53:23Z

‎Auxlin subfamily

Gerard: /* Auxlin subfamily */

2014-12-28T06:53:10Z

‎Auxlin subfamily

Gerard at 03:36, 28 December 2014

2014-12-28T03:36:37Z

Gerard: /* TPIP subfamily */

2014-12-28T03:35:47Z

‎TPIP subfamily

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 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]]
-PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulator of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.
+PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulator of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins. All subfamilies have a specialized C2 domain (C2_PTEN) immediately following the phosphatase domain.
 ===== [[Phosphatase_Subfamily_PTEN|PTEN subfamily]] =====

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]]
-PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulatory of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.
+PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulator of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.
 ===== [[Phosphatase_Subfamily_PTEN|PTEN subfamily]] =====

← Older revision		Revision as of 21:39, 7 April 2015
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−	~~[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTEN\|Family PTEN]]~~
	__NOTOC__		__NOTOC__
		+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTEN\|Family PTEN]]

	PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP\|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulatory of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.		PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP\|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulatory of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.

@@ Line 2: / Line 2: @@
 __NOTOC__
-PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulatory of PI3K signaling. Other defined subfamilies are largely holozoan-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.
+PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulatory of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins.
 ===== [[Phosphatase_Subfamily_PTEN|PTEN subfamily]] =====
@@ Line 8: / Line 8: @@
 ===== [[Phosphatase_Subfamily_VSP|VSP subfamily]] =====
-The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments <cite>Iwasaki08</cite>, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
+The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments <cite>Iwasaki08</cite>, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in [[holozoa]] but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
 ===== [[Phosphatase_Subfamily_Tensin|Tensin subfamily]] =====

@@ Line 8: / Line 8: @@
 ===== [[Phosphatase_Subfamily_VSP|VSP subfamily]] =====
-The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
+The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments <cite>Iwasaki08</cite>, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
 ===== [[Phosphatase_Subfamily_Tensin|Tensin subfamily]] =====
@@ Line 18: / Line 18: @@
 === References ===
 <biblio>
-#keyse06 pmid=17093265
+#Iwasaki08 pmid=18524949
-#farhan13 pmid=23847209
-#schiebel10 pmid=20720150
 </biblio>

@@ Line 15: / Line 15: @@
 Tensin subfamily consists three tensins in human, TNS1, TNS3 and TENC1/TNS2. TNS4 is a distant relative but lacks a phosphatase domain. The subfamily is found in holozoa.
-===== [[Phosphatase_Subfamily_Auxilin|Auxlin subfamily]] =====
+===== [[Phosphatase_Subfamily_Auxilin|Auxilin subfamily]] =====
 Inactive phosphatases that bind phospholipids during clathrin-coated vesicle formation and uncoating. Most also have a kinase domain.

@@ Line 10: / Line 10: @@
 PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001193/overview unpublished data from gOrtholog]).
-===== [[Subfamily_TPIP|TPIP subfamily]] =====
+===== [[Subfamily_VSP|VSP subfamily]] =====
-TPIP subfamily is also known as Voltage Sensitive Phosphatase (VSP). It consists of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE lost its catalytic activity. The subfamily is conserved in holozoan but absent from nematodes and most arthropoda. It usually has a single copy in each species, and the two human copies may arise through duplication after primate emerged.
+The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
 ===== [[Subfamily_Tensin|Tensin subfamily]] =====