Phosphatase Fold AP - Revision history

Mark: /* Evolution */

2015-01-05T15:47:33Z

‎Evolution

Mark at 04:59, 4 January 2015

2015-01-04T04:59:49Z

Mark at 20:59, 30 December 2014

2014-12-30T20:59:11Z

Mark: Created page with "Phosphatase Classification: Fold AP: Superfamily AP (Alkaline phosphatase) Fold AP (Alka..."

2014-12-30T20:58:52Z

Created page with "Phosphatase Classification: Fold AP: Superfamily AP (Alkaline phosphatase) Fold AP (Alka..."

New page

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_AP|Fold AP]]: [[Phosphatase_Superfamily_AP|Superfamily AP]] (Alkaline phosphatase)

Fold AP (Alkaline phosphatase) has a single superfamily, [[Phosphatase_Superfamily_AP|AP]], which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear.

Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold ([http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bah.A.html SCOP]), which contains other enzymes, such as phosphoesterases and sulfatases.

===References===
<biblio>
#Swarup pmid=6167574
#Telfer pmid=8396040
#Chan pmid=3011792
</biblio>

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 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_AP|Fold AP]]
 === Evolution ===
 Alkaline phosphatases are found in metazoa, fungi, some protists, and bacteria, but are absent from most plants. They belong to the alkaline phosphatase-like fold ([http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bah.A.html SCOP]), which contains other enzymes, such as phosphoesterases and sulfatases.
 === Functions ===

← Older revision		Revision as of 20:59, 30 December 2014
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_AP\|Fold AP]]~~: [[Phosphatase_Superfamily_AP\|Superfamily AP]] (Alkaline phosphatase)~~	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_AP\|Fold AP]]

	Fold AP (Alkaline phosphatase) has a single superfamily, [[Phosphatase_Superfamily_AP\|AP]], which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear.		Fold AP (Alkaline phosphatase) has a single superfamily, [[Phosphatase_Superfamily_AP\|AP]], which has a wide variety of substrates, possibly including phosphoproteins. There are four human alkaline phosphatases, named by their tissue expression: [http://www.ncbi.nlm.nih.gov/gene/248 ALPI] (alkaline phosphatase, intestinal), [http://www.ncbi.nlm.nih.gov/gene/250 ALPP] (alkaline phosphatase, placental), [http://www.ncbi.nlm.nih.gov/gene/251 ALPPL2] (alkaline phosphatase, placental-like 2), and [http://www.ncbi.nlm.nih.gov/gene/249 ALPL] (alkaline phosphatase, liver/bone/kidneytissue). Early reports found that ALPL and ALPI can dephosphorylate Histone H2A <cite>Swarup, Chan</cite> and that PLAP is a protein tyrosine phosphatase <cite>Telfer</cite>, but their physiological relevance as protein phosphatases is still unclear.