Phosphatase Fold CC1 - Revision history

Gerard: /* Structure */

2024-04-02T13:03:53Z

‎Structure

2015-11-11T19:57:36Z

2015-11-11T19:57:01Z

2015-10-28T21:16:59Z

‎Structure

2015-10-28T20:43:09Z

2015-10-28T20:42:52Z

2015-10-28T20:38:42Z

2014-12-31T22:56:10Z

2014-12-17T20:45:49Z

Created page with "This is a page stub."

New page

This is a page stub.

@@ Line 4: / Line 4: @@
 === Structure ===
-We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).
+A structural alignment analysis of the crystal structures of five phosphatases of different families, including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses; Paladin and OCA have no structure). showed that all five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP <cite> Andersen01</cite>).
-−
-All the five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP <cite> Andersen01</cite>).
 === References ===

← Older revision		Revision as of 19:57, 11 November 2015
Line 7:		Line 7:

	All the five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP <cite> Andersen01</cite>).		All the five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP <cite> Andersen01</cite>).
		+
		+	=== References ===
		+	<biblio>
		+	#Andersen01 pmid=11585896
		+	</biblio>

@@ Line 6: / Line 6: @@
 We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).
-All the five phosphatases share the same SSs combination of BBHBBHBHHH (B - sheet, H - helix). The phosphatases have different N-terminal SSs. All phosphatases ends at the same SS, helix 5 (H5), except MTMR2, which has additional 4 helices at C terminus. The sheets and helices are inserted at:
+All the five phosphatases share the same secondary structure (SS) combination of E2, E3, H2, E4, E11, H3, E12, H4, H5, H6 (E denotes beta strand, H denotes helix, SS numbered by PTP <cite> Andersen01</cite>).
-* B2-H1: Sac1p
-* H1-B3: MTMR2
-* B3-B4: PTPN1, MTMR2, Sac1p
-* B4-H2: PTPN1, MTMR2
-* H2-B5: Sac1p
-* H3-H4: MTMR2
-−
-We are uncertain about whether Sac1p has helix 5, because the region is not included in the available crystal structures (3LWT and 4TU3). However, we know the region is necessary for its catalytic activity (see [[Phosphatase_Family_Sac|Sac]]).

← Older revision		Revision as of 21:16, 28 October 2015
Line 14:		Line 14:
	* H3-H4: MTMR2		* H3-H4: MTMR2

−	We are uncertain about whether Sac1p has helix 5, because the region is not included in the available crystal structures (3LWT and 4TU3).	+	We are uncertain about whether Sac1p has helix 5, because the region is not included in the available crystal structures (3LWT and 4TU3). However, we know the region is necessary for its catalytic activity (see [[Phosphatase_Family_Sac\|Sac]]).

@@ Line 3: / Line 3: @@
 Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1|CC1]].
-=== Comparing the secondary structure across families ===
+=== Structure ===
 We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).

← Older revision		Revision as of 20:38, 28 October 2015
Line 1:		Line 1:
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]
−

	Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1\|CC1]].		Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1\|CC1]].
		+
		+	=== Comparing the secondary structure across families ===
		+	We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).
		+
		+	All CC1 families share the same SSs combination of BBHBBHBHHH (B - sheet, H - helix). The families have different N-terminal SSs. The sheets and helices are inserted at:
		+	* B2-H1: Sac1p
		+	* H1-B3: MTMR2
		+	* B3-B4: PTPN1, MTMR2, Sac1p
		+	* B4-H2: PTPN1, MTMR2
		+	* H2-B5: Sac1p
		+	* H3-H4: MTMR2
		+
		+	MTMR2 has additional 4 helices at C terminus.

← Older revision		Revision as of 22:56, 31 December 2014
Line 1:		Line 1:
−	~~This is~~ a ~~page stub~~.	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]
		+
		+
		+	Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1\|CC1]].