Phosphatase Subfamily ACP6 - Revision history

Gerard: /* Evolution */

2016-10-25T22:50:25Z

‎Evolution

2016-10-25T22:49:43Z

‎Function

2016-10-25T22:48:26Z

2016-10-25T22:44:28Z

‎Evolution

2016-10-25T22:42:27Z

2016-10-25T21:49:52Z

2015-06-04T04:49:35Z

2015-06-03T18:19:14Z

2015-06-03T18:09:30Z

‎Domain

2015-06-03T18:08:09Z

‎Function

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 === Evolution ===
-The ACP6 subfamily is found across [[holozoa]] and absent from [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]]. Both Drosophila and C. elegans lack ACP6, but both have expansions in the analogous [[Phosphatase_Subfamily_ACP2|ACP2]] subfamily. The ACP6 subfamily is also absent from S. cerevisiae but present in some other fungi, and detectable in some other basal eukaryotes.
+The ACP6 subfamily is found across [[holozoa]] and absent from [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]], including Drosophila and C. elegans. ACP6 is also absent from S. cerevisiae but present in some other fungi, and detectable in some other basal eukaryotes.
 === Domain ===

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 Human ACP6 is a lysophosphatidic acid (LPA)-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate <cite>Li13</cite>. LPA is a phospholipid involved in cell signaling as a secreted ligand for GPCRs. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including one through ACP6 <cite>Li13</cite>.
-ACP6 is localized in the mitochondria with ubiquitous expression throughout all tissues, and high expression levels in kidney, heart, small intestine, muscle, and liver <cite> Hiroyama99 </cite>. The active form of ACP6 is monomer, while human ACPP of [[Phosphatase_Subfamily_ACP2|ACP2 subfamily]] is active as dimer <cite>Li13</cite>.
+ACP6 is localized in the mitochondria with ubiquitous expression throughout all tissues, and high expression levels in kidney, heart, small intestine, muscle, and liver <cite> Hiroyama99 </cite>.
 === References ===

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 === Function ===
-Human ACP6 is a lysophosphatidic acid (LPA)-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate <cite>Li13</cite>. LPA is a phospholipid involved in cell signaling through GPCR pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including one through ACP6 <cite>Li13</cite>.
+Human ACP6 is a lysophosphatidic acid (LPA)-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate <cite>Li13</cite>. LPA is a phospholipid involved in cell signaling as a secreted ligand for GPCRs. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including one through ACP6 <cite>Li13</cite>.
 ACP6 is localized in the mitochondria with ubiquitous expression throughout all tissues, and high expression levels in kidney, heart, small intestine, muscle, and liver <cite> Hiroyama99 </cite>. The active form of ACP6 is monomer, while human ACPP of [[Phosphatase_Subfamily_ACP2|ACP2 subfamily]] is active as dimer <cite>Li13</cite>.

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 === Evolution ===
-The ACP6 subfamily is found across [[holozoa]] and absent from [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]]. Furthermore, BLASTing human and monosiga ACP6 against NR database showed the closest genes found in ecdysozoa belong to the ACP2 subfamily, so the ACP6 subfamily was indeed lost in ecdysozoa. And interestingly, both ''Drosophila melanogaster'' and ''C. elegans'' have remarkable expansions in another subfamily in HP1 family [[Phosphatase_Subfamily_ACP2|ACP2]]. The ACP6 subfamily is also absent from budding yeast, but reciprocal BLAST and internal orthology database showed many other fungi have ACP6. ACP6s were also found in some but not all basal eukaryotes, by BLAST and from internal database. In sum, the ACP6 subfamily probably emerged in [[Phosphatase_Glossary#Opisthokont|opisthokont]] or even earlier and was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]].
+The ACP6 subfamily is found across [[holozoa]] and absent from [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]]. Both Drosophila and C. elegans lack ACP6, but both have expansions in the analogous [[Phosphatase_Subfamily_ACP2|ACP2]] subfamily. The ACP6 subfamily is also absent from S. cerevisiae but present in some other fungi, and detectable in some other basal eukaryotes.
 === Domain ===

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 === Function ===
-Human ACP6 is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate <cite>Li13</cite>. Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through G-protein-coupled receptors pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including the one through ACP6 <cite>Li13</cite>.
+Human ACP6 is a lysophosphatidic acid (LPA)-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate <cite>Li13</cite>. LPA is a phospholipid involved in cell signaling through GPCR pathways. It is also involved in balancing the lipid composition inside the cell, and modulates the function of lipid rafts as an intermediate in phospholipid metabolism. LPA synthesis occurs through a number of pathways; LPA degradation occurs through three known pathways, including one through ACP6 <cite>Li13</cite>.
 ACP6 is localized in the mitochondria with ubiquitous expression throughout all tissues, and high expression levels in kidney, heart, small intestine, muscle, and liver <cite> Hiroyama99 </cite>. The active form of ACP6 is monomer, while human ACPP of [[Phosphatase_Subfamily_ACP2|ACP2 subfamily]] is active as dimer <cite>Li13</cite>.

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2]]: [[Phosphatase_Subfamily_ACP6|Subfamily ACP6]]
+[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]]: [[Phosphatase_Family_HP2|Family HP, branch 2]]: [[Phosphatase_Subfamily_ACP6|Subfamily ACP6]]
 === Evolution ===