Phosphatase Subfamily CUT - Revision history

Gerard at 00:13, 14 April 2017

2017-04-14T00:13:19Z

Mark: /* Function */

2015-03-22T01:02:08Z

‎Function

Gerard: /* Evolution */

2015-03-21T19:51:50Z

‎Evolution

Gerard: /* Function */

2015-03-11T05:44:17Z

‎Function

Mark at 04:59, 9 March 2015

2015-03-09T04:59:47Z

Mark at 04:59, 9 March 2015

2015-03-09T04:59:09Z

Mark at 04:58, 9 March 2015

2015-03-09T04:58:50Z

Mark: /* References */

2015-03-09T04:58:04Z

‎References

Mark at 04:57, 9 March 2015

2015-03-09T04:57:51Z

Mark at 18:57, 16 June 2014

2014-06-16T18:57:43Z

@@ Line 5: / Line 5: @@
 === Evolution ===
-This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods.
+This family is present throughout eukaryotes, mostly single-copy but with several duplications <cite>Chen</cite>. It is lost from Drosophila but present in other arthropods.
 === Domain ===
@@ Line 11: / Line 11: @@
 === Function ===
-Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
+Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. A PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
 === References ===
 <biblio>
 #Barbe pmid=18029348
 #Reinders pmid=16823961
 #Richter pmid=20186120
 #Youssar pmid=16807008
 </biblio>

@@ Line 11: / Line 11: @@
 === Function ===
-Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
+Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
 === References ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-This family is present throughout eukaryotes (while it is absent from fruit fly, it is found in other arthropods). It has a single copy in mammals, 2 copies in chicken (but single copy in turkey), 2-3 copies in fishes, 2-3 copies in fungi, 2-3 copies Discicristates, and even 6 copies in Tetrahymena. Phylogenetic tree shows these copies are due to different duplication events.
+This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods.
 === Domain ===

@@ Line 11: / Line 11: @@
 === Function ===
-Various Cut genes have been localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
+Cut proteins are localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
 === References ===

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 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_CUT|CUT]]
+[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]: [[Phosphatase_Subfamily_CUT|Subfamily CUT]]
 Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.

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 == Notes ==
-Various Cut genes have been localized to the mitochondria <cite>Barbe, Reinders</cite>. CRCR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
+Various Cut genes have been localized to the mitochondria <cite>Barbe, Reinders</cite>. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase <cite>Richter</cite> and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress <cite>Youssar</cite>. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
 == References ==