Phosphatase Subfamily DSP15 - Revision history

Gerard: /* Functions */

2017-03-22T18:58:21Z

‎Functions

Gerard at 18:52, 22 March 2017

2017-03-22T18:52:40Z

Mark at 17:59, 5 March 2015

2015-03-05T17:59:30Z

Mark: /* Evolution */

2015-03-05T17:56:09Z

‎Evolution

Mark at 04:59, 3 March 2015

2015-03-03T04:59:35Z

Mark: /* Function */

2015-03-03T03:47:27Z

‎Function

Mark: /* Evolution */

2015-03-03T03:44:49Z

‎Evolution

Mark: /* Domain */

2015-03-03T03:44:31Z

‎Domain

Mark at 03:42, 3 March 2015

2015-03-03T03:42:00Z

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

2015-03-03T03:39:58Z

Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

New page

__NOTOC__
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP15|Subfamily DSP15]]

summary

=== Evolution ===
DSP19 subfamily is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data from gOrtholog]).

=== Domain ===
DSP19 has a single domain: phosphatase domain.

=== Function ===

=== References ===
<biblio>

</biblio>

← Older revision		Revision as of 18:58, 22 March 2017
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	DUSP22 may represent a tumor-suppressor gene, since its loss may contribute to the pathogenesis of cutaneous anaplastic large-cell lymphomas (ALCLs) according to clinic cases <cite>Csikesz13</cite>.		DUSP22 may represent a tumor-suppressor gene, since its loss may contribute to the pathogenesis of cutaneous anaplastic large-cell lymphomas (ALCLs) according to clinic cases <cite>Csikesz13</cite>.
		+
		+	The C. elegans and Drosophila homologs of DSP15 have not been experimentally characterized.

	=== References ===		=== References ===

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP15|Subfamily DSP15]]
-DSP15 subfamily emerged in metazoan and duplicated in vertebrates. It is characterized by a N-termnal myristoylation site which targets it to plasma membrane. Limited is known about its molecular function.
+DSP15 subfamily emerged in metazoan and duplicated in vertebrates. It is characterized by a N-termnal myristoylation site which targets it to plasma membrane. Little is known about its molecular function.
 === Evolution ===
-DSP15 subfamily is found across metazoan, even in amoebozoan and excavate, there are DSP15-like genes. It usually has a single copy in invertebrate genomes and two copies in vertebrate genomes, which indicated the subfamily emerged in metazoan and duplicated in vertebrates.
+DSP15 subfamily is found across metazoa, and likely homologs exist in even in several protist lineages. It usually has a single copy in invertebrate genomes and two copies in vertebrate genomes (DUSP15 and DUSP22 in human).
 === Domain ===
@@ Line 11: / Line 11: @@
 === Functions ===
 ====== DUSP15 (VHY) ======

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP15|Subfamily DSP15]]
-summary...
+DSP15 subfamily emerged in metazoan and duplicated in vertebrates. It is characterized by a N-termnal myristoylation site which targets it to plasma membrane. Limited is known about its molecular function.
 === Evolution ===

@@ Line 5: / Line 5: @@
 === Evolution ===
-Pending..
+DSP15 subfamily is found across metazoan, even in amoebozoan and excavate, there are DSP15-like genes. It usually has a single copy in invertebrate genomes and two copies in vertebrate genomes, which indicated the subfamily emerged in metazoan and duplicated in vertebrates.
 === Domain ===

@@ Line 2: / Line 2: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP15|Subfamily DSP15]]
-summary
+summary...
 === Evolution ===
@@ Line 8: / Line 8: @@
 === Domain ===
-DSP15 has a N-terminal myristoylation site and a phosphatase domain.
+DSP15 has a N-terminal [http://en.wikipedia.org/wiki/Myristoylation myristoylation] site and a phosphatase domain. The two members in human genome DUSP15 and DUSP22 are myristoylated at Gly-2. The myristoylation site targets the protein to plasma memrane. Mutation of the myristoylation site Gly-2 of DUSP15 abrogated membrane location <cite>Alonso04</cite>.
 === Functions ===
@@ Line 14: / Line 14: @@
 ====== DUSP15 (VHY) ======
 === References ===
 <biblio>
+#Alonso04 pmid=15138252
 </biblio>

Phosphatase Subfamily DSP15 - Revision history

Gerard: /* Functions */

Gerard at 18:52, 22 March 2017

Mark at 17:59, 5 March 2015

Mark: /* Evolution */

Mark at 04:59, 3 March 2015

Mark: /* Function */

Mark: /* Evolution */

Mark: /* Domain */

Mark at 03:42, 3 March 2015

Mark: Created page with "__NOTOC__ Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."

Mark: Created page with "NOTOC Phosphatase Classification: Fold CC1: Superfamily CC1: Phosphatase_Family_..."