Phosphatase Subfamily PTPN3 - Revision history

Gerard: /* PTPN3 (PTPH1) */

2017-07-26T08:12:14Z

‎PTPN3 (PTPH1)

Gerard: /* Evolution */

2017-07-26T08:10:35Z

‎Evolution

Gerard at 08:09, 26 July 2017

2017-07-26T08:09:44Z

Mark: /* References */

2015-06-17T19:15:57Z

‎References

Mark: /* PTPN3 (PTPH1) */

2015-06-17T19:15:34Z

‎PTPN3 (PTPH1)

Mark: /* References */

2015-04-12T20:53:47Z

‎References

Mark at 20:53, 12 April 2015

2015-04-12T20:53:32Z

Mark: /* References */

2015-04-01T20:04:22Z

‎References

Mark: /* PTPN4 (PTPMEG) */

2015-04-01T20:03:56Z

‎PTPN4 (PTPMEG)

Mark at 23:25, 24 March 2015

2015-03-24T23:25:38Z

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 ===== PTPN3 (PTPH1) =====
 PTPN3/PTPH1 is widely expressed in different tissues; it is expressed at a relatively higher level in skin and skeletal muscle according to [http://www.gtexportal.org/home/gene/PTPN3 GTEx].
+Substrates include:
-PTPN3/PTPH1 substrates:
 * Cell cycle regulator VCP (p97/CDC48) <cite>Zhang99</cite>.
 * T cell receptor zeta subunit <cite>Sozio04</cite>.
@@ Line 22: / Line 21: @@
 * p38γ mitogen-activated protein kinase (MAPK). The interaction is mediated through PDZ binding <cite>Hou10</cite>, and vice versa, p38γ is also a kinase of PTPN3 <cite>Hou11</cite>.
-PTPN3/PTPH1 interacts with and regulates Cardiac sodium channel Na(v)1.5. The interaction is mediated by the PDZ domain of PTPN3 and the PDZ-domain binding motif of Na(v)1.5 <cite>Jespersen06</cite>. PTPN3/PTPH1 is a negative regulator of Tumor necrosis factor alpha-convertase (TACE), a metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical for proper murine development. The interaction is mediated via binding of the PDZ domain of PTPH1 to the COOH terminus of TACE <cite>Zheng02</cite>. PTPN3/PTPH1 interacts with adaptor protein 14-3-3beta in a manner dependent on the phosphorylation state of PTPN3 <cite>Zhang97</cite>. PTPN3/PTPH1 binds to vitamin D receptor (VDR) and increases VDR's cytoplasmic accumulation, leading to their mutual stabilization and stimulating breast cancer growth <cite>Zhi11</cite>. PTPN3/PTPH1 controls growth hormone receptor (GHR) signaling <cite>Pilecka07</cite>.
+PTPN3 interacts with and regulates Cardiac sodium channel Na(v)1.5. The interaction is mediated by the PDZ domain of PTPN3 and the PDZ-domain binding motif of Na(v)1.5 <cite>Jespersen06</cite>. PTPN3 is a negative regulator of Tumor necrosis factor alpha-convertase (TACE), a metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical for proper murine development. The interaction is mediated via binding of the PDZ domain of PTPN2 to the COOH terminus of TACE <cite>Zheng02</cite>. PTPN3 interacts with adaptor protein 14-3-3beta in a manner dependent on the phosphorylation state of PTPN3 <cite>Zhang97</cite>. PTPN3 binds to vitamin D receptor (VDR) and increases VDR's cytoplasmic accumulation, leading to their mutual stabilization and stimulating breast cancer growth <cite>Zhi11</cite>. PTPN3 controls growth hormone receptor (GHR) signaling <cite>Pilecka07</cite>.
-PTPN3/PTPH1 is implicated in breast cancer <cite>Suresh14, Zhi11</cite>, intrahepatic cholangiocarcinoma <cite>Gao14</cite>, and human hepatocellular carcinomas <cite>Ikuta94</cite>.
+PTPN3 is implicated in breast cancer <cite>Suresh14, Zhi11</cite>, intrahepatic cholangiocarcinoma <cite>Gao14</cite>, and human hepatocellular carcinomas <cite>Ikuta94</cite>.
 ===== PTPN4 (PTPMEG) =====

@@ Line 3: / Line 3: @@
 ===Evolution===
-The PTPN3 subfamily emerged in holozoa and duplicated in vertebrates. Human has two members of this subfamily, PTPN3/PTPH1 and PTPN4/PTPMEG.
+The PTPN3 subfamily emerged in holozoa and duplicated in vertebrates. Human has two members, PTPN3 (PTPH1) and PTPN4 (PTP-MEG).
 ===Domain ===

← Older revision		Revision as of 08:09, 26 July 2017
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN3\|Subfamily PTPN3]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN3\|Subfamily PTPN3]]

@@ Line 49: / Line 49: @@
 #Jespersen06 pmid=16930557
 #Maisonneuve14 pmid=25158884
 #Park00 pmid=11054567
 #Pilecka07 pmid=17921143

@@ Line 17: / Line 17: @@
 * T cell receptor zeta subunit <cite>Sozio04</cite>.
 * Estrogen receptor at Tyr-537 <cite>Suresh14</cite>.
-* Epidermal growth factor receptor (EGFR) pathway substrate 15 (Eps15)  at Tyr-849<cite>Chen15</cite> .
+* Epidermal growth factor receptor (EGFR) pathway substrate 15 (Eps15)  at Tyr-849<cite>Chen15</cite>.
 * p38γ mitogen-activated protein kinase (MAPK). The interaction is mediated through PDZ binding <cite>Hou10</cite>, and vice versa, p38γ is also a kinase of PTPN3 <cite>Hou11</cite>.

@@ Line 35: / Line 35: @@
 ===References===
 <biblio>
 #Gao14 pmid=24503127
 #Gu91 pmid=1648233

@@ Line 37: / Line 37: @@
 #Hou10 pmid=20332238
 #Hou11 pmid=22730326
 #Ikuta94 pmid=7874267
 #Itoh93 pmid=8253532

@@ Line 20: / Line 20: @@
 ===== PTPN4 (PTPMEG) =====
-PTPN4/PTPMEG has been shown to be specifically expressed in testis <cite>Park00</cite>. However, RNA-seq data in [http://www.gtexportal.org/home/gene/PTPN4 GTEx] shows it is widely expressed in different tissues, most abundantly in cerebellum and the expression level in testis is close to the average.
+PTPN4/PTPMEG primarily locates in the membrane and cytoskeleton <cite>Gu91, Gu96a</cite>. PTPN4/PTPMEG has been shown to be specifically expressed in testis <cite>Park00</cite>. However, RNA-seq data in [http://www.gtexportal.org/home/gene/PTPN4 GTEx] shows it is widely expressed in different tissues, most abundantly in cerebellum and the expression level in testis is close to the average.
 PTPN4 dephosphorylates T cell receptor (TCR) at ITAM motifs, a conserved signaling motif and are present in one or more copies in the cytoplasmic tails of the CD3 γ, δ, ε and TCR ζ subunits <cite>Young08</cite>.
-PTPN4/PTPMEG interacts with but does not directly phosphorylates glutamate receptor delta 2 and epsilon subunits <cite>Hironaka00</cite>.
+PTPN4 dephosphorylates  TRIF-related adaptor molecule (TRAM, also known as TICAM2), therefore inhibiting TRIF-dependent [http://en.wikipedia.org/wiki/TLR4 TLR4 pathway] <cite>Huai15</cite>.
-PTPN4/PTPMEG primarily locates in the membrane and cytoskeleton <cite>Gu91, Gu96a</cite>.
+PTPN4/PTPMEG interacts with but does not directly phosphorylates glutamate receptor delta 2 and epsilon subunits <cite>Hironaka00</cite>.
 ===References===

@@ Line 1: / Line 1: @@
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN3|Subfamily PTPN3]]
-===Evolution===
+===Functions===
-===Domain ===
+PTPN3/PTPH1 dephosphorylates cell cycle regulator VCP (p97/CDC48) <cite>Zhang99</cite>, the T cell receptor zeta subunit <cite>Sozio04</cite>, and estrogen receptor at Tyr-537 <cite>Suresh14</cite>. It is also a specific phosphatase of p38γ mitogen-activated protein kinase (MAPK) through PDZ binding <cite>Hou10</cite>, and vice versa, p38γ is also a kinase of PTPN3 <cite>Hou11</cite>.
-PTPN3 subfamily has a domain combination of FERM domain, PEST sequence, PDZ domain and phosphatase domain <cite>Gu96b</cite>.
-===Functions===
+PTPN3/PTPH1 interacts with and regulates Cardiac sodium channel Na(v)1.5. The interaction is mediated by the PDZ domain of PTPN3 and the PDZ-domain binding motif of Na(v)1.5 <cite>Jespersen06</cite>. PTPN3/PTPH1 is a negative regulator of Tumor necrosis factor alpha-convertase (TACE), a metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical for proper murine development. The interaction is mediated via binding of the PDZ domain of PTPH1 to the COOH terminus of TACE <cite>Zheng02</cite>. PTPN3/PTPH1 interacts with adaptor protein 14-3-3beta in a manner dependent on the phosphorylation state of PTPN3 <cite>Zhang97</cite>. PTPN3/PTPH1 binds to vitamin D receptor (VDR) and increases VDR's cytoplasmic accumulation, leading to their mutual stabilization and stimulating breast cancer growth <cite>Zhi11</cite>. PTPN3/PTPH1 controls growth hormone receptor (GHR) signaling <cite>Pilecka07</cite>.
 ===== PTPN4 (PTPMEG) =====
-PTPN4/PTPMEG has been shown to be specifically expressed in testis <cite>Park00</cite>. However, RNA-seq data in [http://www.gtexportal.org/home/gene/PTPN4 GTEx] shows it is most abundantly expressed in cerebellum and the expression level in testis is close to the average.
+PTPN4/PTPMEG has been shown to be specifically expressed in testis <cite>Park00</cite>. However, RNA-seq data in [http://www.gtexportal.org/home/gene/PTPN4 GTEx] shows it is widely expressed in different tissues, most abundantly in cerebellum and the expression level in testis is close to the average.
 PTPN4 dephosphorylates T cell receptor (TCR) at ITAM motifs, a conserved signaling motif and are present in one or more copies in the cytoplasmic tails of the CD3 γ, δ, ε and TCR ζ subunits <cite>Young08</cite>.
@@ Line 25: / Line 30: @@
 ===References===
 <biblio>
 #Gu91 pmid=1648233
 #Gu96a pmid=8910369
 #Gu96b pmid=8917530
 #Hironaka00 pmid=10748123
 #Park00 pmid=11054567
 #Young08 pmid=18614237
 </biblio>