Phosphatase Subfamily PTPN6 - Revision history

Mark: /* References */

2017-01-07T20:36:53Z

‎References

Mark: /* PTPN11/SHP2 */

2017-01-07T20:36:24Z

‎PTPN11/SHP2

Gerard at 04:30, 10 May 2016

2016-05-10T04:30:07Z

Gerard: /* PTPN11 */

2016-05-10T03:07:13Z

‎PTPN11

Gerard: /* PTPN6 */

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‎PTPN6

Gerard: /* Drosophila Corkscrew (csw) */

2016-05-10T03:03:35Z

‎Drosophila Corkscrew (csw)

Gerard at 03:02, 10 May 2016

2016-05-10T03:02:43Z

Gerard at 03:00, 10 May 2016

2016-05-10T03:00:20Z

Mark at 19:12, 5 July 2015

2015-07-05T19:12:29Z

Mark: /* References */

2015-07-05T19:11:33Z

‎References

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 #Perino14 pmid=25100060
 #Poole05 pmid=16084691
 #Xiao15 pmid=25790452
 </biblio>

← Older revision		Revision as of 20:36, 7 January 2017
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	PTPN11 (SHP-2) can operate as a scaffold, facilitating the recruitment of kinase Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.		PTPN11 (SHP-2) can operate as a scaffold, facilitating the recruitment of kinase Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.
		+
		+	PTPN11 (SHP-2) promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients <cite>Xiang2017</cite>.

	===== Drosophila Corkscrew (csw) =====		===== Drosophila Corkscrew (csw) =====

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 ===== PTPN11/SHP2 =====
 PTPN11 is a major player in receptor tyrosine kinase signaling to Ras, by a variety of mechanisms.
 PKA phosphorylates PTPN11/SHP-2 at Thr-73 and Ser-189 in two SH2 domains, respectively. The phosphorylation inhibits ligand-binding mediated by SH2 domains and phosphatase activity <cite>Burmeister15</cite>.

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 PTPN6 expression by NK cells is required for in vivo-mismatched bone marrow allograft rejection as well as for NK memory responses to happen <cite>Gumbleton15</cite>.
-===== PTPN11 =====
+===== PTPN11/SHP2 =====
 PKA phosphorylates PTPN11/SHP-2 at Thr-73 and Ser-189 in two SH2 domains, respectively. The phosphorylation inhibits ligand-binding mediated by SH2 domains and phosphatase activity <cite>Burmeister15</cite>.
 PTPN11/SHP-2 acts as a regulator of the tyrosyl phosphorylation of FGFR4 and of its immediate target FRS2α, thus being essential for the FGF15/19-mediated activation of the FGFR4/P-ERK1/2/PKC signaling pathway as a integrator of hepatic [http://en.wikipedia.org/wiki/Bile_acid bile acid] and FGF15/FGF19 signaling <cite>Perino14</cite>.
-A PTPN11 allele encoding a catalytically impaired protein was found in a patient with a Noonan syndrome phenotype <cite>Edwards14</cite>. But, it is unclear whether PTPN11 is a general caustic gene of Noonan syndrome phenotype.
+A PTPN11 allele encoding a catalytically impaired protein was found in a patient with a Noonan syndrome phenotype <cite>Edwards14</cite>. But, it is unclear whether PTPN11 is a general casuative gene of Noonan syndrome.
-PTPN11 (SHP-2) can operat as a scaffold, facilitating the recruitment of kinase Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.
+PTPN11 (SHP-2) can operate as a scaffold, facilitating the recruitment of kinase Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.
 ===== Drosophila Corkscrew (csw) =====

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 The PTPN6 subfamiy is extensively studied and reviewed (e.g. <cite>Neel03, Lorenz09</cite>). Below are some examples of their functions:
-===== PTPN6 =====
+===== PTPN6/SHP1 =====
 PTPN6/SHP-1 dephosphorylates and inhibites Transient receptor potential vanilloid 1 (TRPV1) receptors in rat dorsal root ganglions (DRGs) <cite>Xiao15</cite>. [http://en.wikipedia.org/wiki/TRPV1 TRPV1] is a nonselective cation channel that provides sensation of scalding heat and pain (nociception).

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 ===== Drosophila Corkscrew (csw) =====
-Drosophila has a single gene of PTPN6 subfamily, corkscrew (css). It binds to and dephosphorylates Draper-II, an alternative splice variant of Draper <cite>Logan12</cite>, which is orthologous to human [http://www.ncbi.nlm.nih.gov/gene/84465 MEGF11] (multiple EGF-like-domains 11).
+Drosophila has a single gene of PTPN6 subfamily, corkscrew (csw). It binds to and dephosphorylates Draper-II, an alternative splice variant of Draper <cite>Logan12</cite>, which is orthologous to human [http://www.ncbi.nlm.nih.gov/gene/84465 MEGF11] (multiple EGF-like-domains 11).
 ===References===

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 ===Domain ===
-The PTPN6 subfamily has two tandem SH2 domains and phosphatase domain. Besides the structural domains, it has a C-terminal tail important for the regulation of its function <cite>Poole05</cite>.  For example, PTPN11 (SHP-2) has a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.
+The PTPN6 subfamily has two tandem SH2 domains and phosphatase domain. Besides the structural domains, it has a C-terminal tail important for the regulation of its function <cite>Poole05</cite>.  For example, PTPN11 (SHP2) has a carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM) <cite>Deng15</cite>.
 The genes of PTPN6 subfamily have multiple alternative splicing isoforms, which may result in different domain combinations. For instance, the longest isoform of Drosophila genus do not have the first SH2 domain (technical notes: the longest isoforms in [http://ensemblgenomes.org Ensembl genomes]).
 ===Functions===
-Human PTPN6 (SHP-1) and PTPN11 (SHP-2) are proposed to have different roles in signal transduction: PTPN6/SHP-1 plays a largely negative signalling role, whereas PTPN11/SHP-2 plays a largely positive role in cell signalling leading to cell activation. Expression of PTPN6/SHP-1 is restricted mainly to haematopoietic cells whereas PTPN11/SHP-2 is more widely expressed; both enzymes are expressed in many haematopoietic cells <cite>Poole05</cite>.
+Human PTPN6 (SHP1) and PTPN11 (SHP2) are proposed to have different roles in signal transduction: PTPN6 plays a largely negative signalling role, whereas PTPN11 plays a largely positive role in cell signalling leading to cell activation. Expression of PTPN6 is restricted mainly to haematopoietic cells whereas PTPN11 is more widely expressed; both enzymes are expressed in many haematopoietic cells <cite>Poole05</cite>.
-The PTPN6/SHP subfamiy is under extensive studies and see more in reviews (e.g. <cite>Neel03, Lorenz09</cite>) and papers. Below are some examples of their functions:
+The PTPN6 subfamiy is extensively studied and reviewed (e.g. <cite>Neel03, Lorenz09</cite>). Below are some examples of their functions:
-===== PTPN6 (SHP-1) =====
+===== PTPN6 =====
 PTPN6/SHP-1 dephosphorylates and inhibites Transient receptor potential vanilloid 1 (TRPV1) receptors in rat dorsal root ganglions (DRGs) <cite>Xiao15</cite>. [http://en.wikipedia.org/wiki/TRPV1 TRPV1] is a nonselective cation channel that provides sensation of scalding heat and pain (nociception).
@@ Line 22: / Line 22: @@
 PTPN6 expression by NK cells is required for in vivo-mismatched bone marrow allograft rejection as well as for NK memory responses to happen <cite>Gumbleton15</cite>.
-===== PTPN11 (SHP-2) =====
+===== PTPN11 =====
 PKA phosphorylates PTPN11/SHP-2 at Thr-73 and Ser-189 in two SH2 domains, respectively. The phosphorylation inhibits ligand-binding mediated by SH2 domains and phosphatase activity <cite>Burmeister15</cite>.

← Older revision		Revision as of 03:00, 10 May 2016
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		+	__NOTOC__
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN6\|Subfamily PTPN6]] (SHP/SHIP/csw/Corkscrew)		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN6\|Subfamily PTPN6]] (SHP/SHIP/csw/Corkscrew)

← Older revision		Revision as of 19:12, 5 July 2015
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−	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN6\|Subfamily PTPN6]] (SHP/SHIP)	+	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Fold_CC1\|Fold CC1]]:[[Phosphatase_Superfamily_CC1\|Superfamily CC1]]: [[Phosphatase_Family_PTP\|Family PTP]]: [[Phosphatase_Subfamily_PTPN6\|Subfamily PTPN6]] (SHP/SHIP/csw/Corkscrew)

	===Evolution===		===Evolution===

@@ Line 40: / Line 40: @@
 #Edwards14 pmid=24891296
 #Gumbleton15 pmid=25687756
 #Lorenz09 pmid=19290938
 #Neel03 pmid=12826400