Phosphatase Subfamily VSP - Revision history

Gerard at 20:12, 20 April 2017

2017-04-20T20:12:23Z

2015-04-24T16:59:06Z

2014-12-29T04:52:30Z

‎Evolution

2014-12-29T03:57:41Z

2014-12-29T03:57:14Z

2014-12-29T03:51:24Z

2014-12-29T03:48:59Z

2014-12-29T03:47:47Z

2014-12-29T03:47:34Z

2014-12-29T03:47:15Z

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 ===Evolution===
-VSPs are holozoan-specific and lost in insects and nematodes (but found in arachnids). There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis, and at least one of which is conserved in orangutan.
+VSPs are holozoan-specific and lost in insects and nematodes (but found in arachnids). There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis and other selected tissues. At least one of these is conserved as far as to orangutan, and TPTE2P1 has been reported to have a role in migration of gallbladder cancer cells <cite>Lv</cite>.
 ===Domain Structure===
@@ Line 25: / Line 25: @@
 #Murata pmid=15902207
 #Guipponi pmid=11810268
 #Ogasawara pmid=21172457
 </biblio>

@@ Line 8: / Line 8: @@
 ===Domain Structure===
-VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a PTEN_C2 domain
+VSPs consist of an N-terminal voltage sensor with four transmembrane regions, followed by a phosphatase domain and a C2 domain. The C2 domain modulates VSP's function by interacting with the membrane <cite>Castle15</cite>.
 ===Functions===
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 ===References===
 <biblio>
 #Walker pmid=11716755
 #Iwasaki pmid=18524949

@@ Line 5: / Line 5: @@
 ===Evolution===
-VSPs are holozoan-specific and lost in [[ecdysozoa]]. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis, and at least one of which is conserved in orangutan.
+VSPs are holozoan-specific and lost in insects and nematodes (but found in arachnids). There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis, and at least one of which is conserved in orangutan.
 ===Domain Structure===

@@ Line 20: / Line 20: @@
 ===References===
 <biblio>
-Walker pmid=11716755
+#Walker pmid=11716755
-Iwasaki pmid=18524949
+#Iwasaki pmid=18524949
-Murata pmid=15902207
+#Murata pmid=15902207
-Guipponi pmid=11810268
+#Guipponi pmid=11810268
-Ogasawara pmid=21172457
+#Ogasawara pmid=21172457
 </biblio>

@@ Line 5: / Line 5: @@
 ===Evolution===
-VSPs are holozoan-specific and lost in [ecdysozoa]. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis, and at least one of which is conserved in orangutan.
+VSPs are holozoan-specific and lost in [[ecdysozoa]]. There are two human genes, TPTE (PTEN2) and TPTE2 (TPIP). TPTE is a primate-specific duplicate of the TPTE2 locus (found in human and Gorilla, but not in chimp) There are 7 subfamily pseudogenes, some of which are expressed in testis, and at least one of which is conserved in orangutan.
 ===Domain Structure===