Phosphatase Superfamily RTR1 - Revision history

Gerard at 21:04, 17 October 2016

2016-10-17T21:04:38Z

Gerard at 20:58, 17 October 2016

2016-10-17T20:58:56Z

Mark at 17:02, 1 January 2015

2015-01-01T17:02:03Z

Mark at 17:00, 1 January 2015

2015-01-01T17:00:36Z

Gerard at 02:18, 28 December 2014

2014-12-28T02:18:29Z

Mark at 20:35, 2 May 2014

2014-05-02T20:35:21Z

Mark: Created page with "NOTOC Phosphatase Classification: Superfamily RTR1 RTR1 is a superfamily that has a single family, which ..."

2014-05-02T20:33:50Z

Created page with "__NOTOC__ Phosphatase Classification: Superfamily RTR1 RTR1 is a superfamily that has a single family, which ..."

New page

__NOTOC__

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]

RTR1 is a superfamily that has a single family, which is one of the [[CTD_Phosphorylation|RNA polymerase II C-terminal domain]] phosphatases.

@@ Line 1: / Line 1: @@
 __NOTOC__
 [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_RTR1|Fold RTR1]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]
 RTR1 is a phosphatase conserved in eukaryotes that regulates the [[CTD_Phosphorylation|phosphorylation states of C-terminal domain (CTD) of RNA polymerase II]].
 === Evolution ===
-RTR1 is found in most eukaryotes. It is absent from the sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast (RTR1, RTR2).
+RTR1 is found in most eukaryotes, usually single copy, though duplicated in yeast.
-−
-=== Domain Structure===
-RTR1 has a conserved phosphatase domain with a unique mechanism of action <cite>Irani</cite>. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. The human homolog, RPAP2, has a longer tail with limited sequence similarity to CTR, and is known to bind RNA pol II subunit Rpb6 and to be involved in pre-mRNA 3'-end formation <cite>Wani</cite>.
-−
-=== Function ===
-Yeast RTR1 dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite> and also the anti-termination tyrosine-1 on CTD repeats <cite>hsu14</cite>.
-=== References ===
+=== Family structure ===
-<biblio>
+RTR1 has a single family, also named  [[Phosphatase_Family_RTR1| RTR1]]
-#Mosley09 pmid=19394294
-#Wani pmid= 25639305
-#Irani pmid=26933063
-#Kim09 pmid=19679665
-#xiang12 pmid=22781759
-#hsu14 pmid=24951832
-</biblio>

@@ Line 5: / Line 5: @@
 === Evolution ===
-RTR1 is found in most of eukaryotes. It is absent from Monosiga and sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast.
+RTR1 is found in most eukaryotes. It is absent from the sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast (RTR1, RTR2).
-=== Domain ===
+=== Domain Structure===
-RTR1 has a conserved domain that carries out the phosphatase activity. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. Human RTR1 encoded by gene RPAP2 has a longer tail, but whether its function is unclear given the limited sequence similarity with CTR in yeast RTR1.
+RTR1 has a conserved phosphatase domain with a unique mechanism of action <cite>Irani</cite>. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. The human homolog, RPAP2, has a longer tail with limited sequence similarity to CTR, and is known to bind RNA pol II subunit Rpb6 and to be involved in pre-mRNA 3'-end formation <cite>Wani</cite>.
 === Function ===
-Yeast RTR1 encodes the phosphatase that dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite>. Moreover, it has been shown that Rtr1 dephosphorylates not only serine-5 but also the newly described anti-termination tyrosine 1 marker on CTD repeats <cite>hsu14</cite>.
+Yeast RTR1 dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite> and also the anti-termination tyrosine-1 on CTD repeats <cite>hsu14</cite>.
 === References ===
 <biblio>
 #Mosley09 pmid=19394294
 #Kim09 pmid=19679665
 #xiang12 pmid=22781759
 #hsu14 pmid=24951832
 </biblio>

@@ Line 1: / Line 1: @@
 __NOTOC__
-[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]
+RTR1 is a phosphatase conserved in eukaryotes that regulates the [[CTD_Phosphorylation|phosphorylation states of C-terminal domain (CTD) of RNA polymerase II]].
-RTR1 is a superfamily that has a single family, [[Phosphatase_Family_Rtr1|RTR1]] which is one of the [[CTD_Phosphorylation|RNA polymerase II C-terminal domain]] phosphatases.
+=== Evolution ===

← Older revision		Revision as of 17:00, 1 January 2015
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	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]

−	RTR1 is a superfamily that has a single family, [[Phosphatase_Family_Rtr1\|RTR1]] which ~~may be~~ one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.	+	RTR1 is a superfamily that has a single family, [[Phosphatase_Family_Rtr1\|RTR1]] which is one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.

← Older revision		Revision as of 02:18, 28 December 2014
Line 3:		Line 3:
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]

−	RTR1 is a superfamily that has a single family, which may be one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.	+	RTR1 is a superfamily that has a single family, [[Phosphatase_Family_Rtr1\|RTR1]] which may be one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.

← Older revision		Revision as of 20:35, 2 May 2014
Line 3:		Line 3:
	[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]		[[Phosphatase classification\|Phosphatase Classification]]: [[Phosphatase_Superfamily_RTR1\|Superfamily RTR1]]

−	RTR1 is a superfamily that has a single family, which is one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.	+	RTR1 is a superfamily that has a single family, which may be one of the [[CTD_Phosphorylation\|RNA polymerase II C-terminal domain]] phosphatases.