Phosphatase Family HP1

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Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family

Subfamilies found in human

PGAM
PGAM5

PGAM5 is a protein phosphatase conserved in metazoan. It has distinct substrates.

TIGAR

Vertebrate TIGAR functions as a fructose- 2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.

STS (TULA or UBASH3)

STS is protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoan.

PFKFB

Other subfamilies

Cele-STS-like
TFC7
HP1LE
Dicty-HP1-sf1