Phosphatase Family HP1

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Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): HP, branch1 family

Subfamilies found in human

PGAM

PGAM subfamily mainly functions as glycolytic enzymes regulating intracellular levels of its substrate 3-phosphoglycerate and product 2-phosphoglycerate. Human BPGM is a 2,3-bisphosphoglycerate mutase. They are found throughout most eukaryotes.

PGAM5

PGAM5 is a protein phosphatase conserved in metazoan. It has distinct substrates.

TIGAR

Vertebrate TIGAR functions as a fructose-2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.

STS (TULA or UBASH3)

STS is protein tyrosine phosphatase involved in T-cell receptor signaling. In particular, STS dephosphorylates kinases Syk and ZAP-70 of Syk subfamily. STS is conserved in metazoan.

PFKFB

PFKFB is a bifunctional enzyme responsible for the synthesis (as kinase) and degradation (as phosphatase) of fructose-2,6-bisphosphatase that is a signal molecule that controls glycolysis. Its two opposite enzymatic activities are encoded in two separate domains, N-terminal kinase domain and C-terminal phosphatase domain. PFKFB is found in most if not all eukaryotes. It emerged by gene fusion of the ancestors of the gene containing kinase domain and that containing phosphatase domain.

Other subfamilies

Cele-STS-like
TFC7
HP1LE
Dicty-HP1-sf1