Difference between revisions of "Phosphatase Family HP2"

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(Subfamilies)
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2]]
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase): [[Phosphatase_Family_HP2|Family HP, branch 2 (HP2)]]
  
 
Refer to Pfam ID [http://pfam.xfam.org/family/PF00328 PF00328] for general information.
 
Refer to Pfam ID [http://pfam.xfam.org/family/PF00328 PF00328] for general information.
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=== Subfamilies ===
 
=== Subfamilies ===
  
====== [[Phosphatase_Subfamily_ACP2|ACP2]] ======
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* [[Phosphatase_Subfamily_ACP2|ACP2]] is a '''protein phosphatase''' subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
ACP2 is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
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====== [[Phosphatase_Subfamily_ACP6|ACP6]] ======
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* [[Phosphatase_Subfamily_ACP6|ACP6]]
  
====== [[Phosphatase_Subfamily_MINPP1|MINPP1]] ======
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* [[Phosphatase_Subfamily_MINPP1|MINPP1]] is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
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====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) ======
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* [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans <cite>koike14</cite>. It is widely found in bilateria.
PXYLP1 dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans <cite>koike14</cite>. It is widely found in bilateria.
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======[[Phosphatase_Subfamily_ PPIP5K| PPIP5K]] ======
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* [[Phosphatase_Subfamily_ PPIP5K| PPIP5K]] has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3. It also has a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8.
PPIP5K has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3 and a kinase domain of RimK superfamily. The proteins therefore show kinase activity which convert InsP6 and 5-InsP7 to 1-InsP7 and InsP8.
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======[[Phosphatase_Subfamily_cf60|cf60]] ======
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* [[Phosphatase_Subfamily_cf60|Cf60]] is cellular slime mold specific '''pseudophosphatase'''. It encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.  
Cf60 is cellular slime mold specific.
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===References===
 
===References===

Revision as of 19:42, 30 May 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2 (HP2)

Refer to Pfam ID PF00328 for general information.

Subfamilies

  • ACP2 is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
  • MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan. Known substrates include InsP6 and 2,3-BPG.
  • PXYLP1 (ACPL2) dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [1]. It is widely found in bilateria.
  • PPIP5K has a pseudophosphatase domain which bind to PtdIns(3,4,5)P3. It also has a kinase domain of RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8.
  • Cf60 is cellular slime mold specific pseudophosphatase. It encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies using.

References

  1. Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 | PubMed ID:24425863 | HubMed [koike14]
  2. Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 | PubMed ID:11067847 | HubMed [ACPP_1]
  3. Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104. DOI:10.1074/jbc.273.34.22096 | PubMed ID:9705354 | HubMed [ACPP_2]
All Medline abstracts: PubMed | HubMed