Phosphatase Family NagD

Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD

The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:

• PGP is a ubiquitous HAD subfamily in eukaryotes. The two members in human have distinct functions: PDXP (aka chronophin) dephosphorylates protein cofilin on serine residue, as well as pyridoxal 5'-phosphate; PGP is a putative tyrosine-specific protein phosphatase. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.

• LHPP is a protein histidine phosphatase subfamily conserved in holozoan.

• CUT - no strong evidence supports it has protein phosphatase activity.