Phosphatase Subfamily CG9801
Phosphatase Classification: Fold PPM: Superfamily PPM: Family PPM: Subfamily CG9801
Evolution
CG9801 is found in metazoa but lost in deuterostomes. It is also found in some Amoebozoa. It is most closely related to the PTC7 subfamily, but their sequence similarity is very low
Domain Structure
CG9801 has a PPM phosphatase domain, with additional flanking conserved motifs that have not been annotated.
Function
The function of CG9801 is unclear. In Drosophila, it is reported to be subject to RNA editing [1], to be induced by ecdysone during moulting [2], and to possibly interact with the circadian clock [3]. The C. elegans homolog, F33G12.6, is uncharacterized. Dictyostelium tipA is involved in early development and tip formation [4], and interacts genetically with tipC (VPS13) and tipD (ATG16/ATG16L1), components of the autophagy system [5].
References
- Stapleton M, Carlson JW, and Celniker SE. RNA editing in Drosophila melanogaster: New targets and functional consequences. RNA. 2006 Nov;12(11):1922-32. DOI:10.1261/rna.254306 |
- Beckstead RB, Lam G, and Thummel CS. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol. 2005;6(12):R99. DOI:10.1186/gb-2005-6-12-r99 |
- Dubruille R, Murad A, Rosbash M, and Emery P. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet. 2009 Dec;5(12):e1000787. DOI:10.1371/journal.pgen.1000787 |
- Stege JT, Shaulsky G, and Loomis WF. Sorting of the initial cell types in Dictyostelium is dependent on the tipA gene. Dev Biol. 1997 May 1;185(1):34-41. DOI:10.1006/dbio.1997.8538 |
- Muñoz-Braceras S, Calvo R, and Escalante R. TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells. Autophagy. 2015;11(6):918-27. DOI:10.1080/15548627.2015.1034413 |
