Phosphatase Subfamily LHPP

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Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily LHPP

LHPP is a protein histidine phosphatase conserved in holozoan.

Evolution

LHPP is found across holozoa. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi and oomycetes also have HDHD2-like genes. HDHD2-like genes are also found in a small number of bacteria.

Domain

LHPP subfamily has a single domain, HAD domain.

Function

LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids [1]. HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied.

References

  1. Hiraishi H, Yokoi F, and Kumon A. Bovine liver phosphoamidase as a protein histidine/lysine phosphatase. J Biochem. 1999 Aug;126(2):368-74. DOI:10.1093/oxfordjournals.jbchem.a022459 | PubMed ID:10423531 | HubMed [Hiraishi]