Phosphatase Subfamily LHPP

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Phosphatase Classification: HAD: NagD: HDHD2

HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied. A related protein, LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate two proteins on hisitidine and also has activity against free phospho-lysine and phospho-histidine amino acids [1].

Evolution

Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks an LHPP gene and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi, oomycetes and choanoflagellates also have a family member, which is generally closer to HDHD2 in sequence. A small number of bacterial homologs are also found.


References

  1. Hiraishi H, Yokoi F, and Kumon A. Bovine liver phosphoamidase as a protein histidine/lysine phosphatase. J Biochem. 1999 Aug;126(2):368-74. DOI:10.1093/oxfordjournals.jbchem.a022459 | PubMed ID:10423531 | HubMed [Hiraishi]