Difference between revisions of "Phosphatase Subfamily YMR1"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_YMR1|Subfamily YMR1]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Myotubularin|Family Myotubularin]]: [[Phosphatase_Subfamily_YMR1|Subfamily YMR1]] | ||
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===Evolution=== | ===Evolution=== | ||
| − | YMR1 is found in most fungi. | + | YMR1 is found in most fungi <cite>Chen</cite>. |
===Domain Structure=== | ===Domain Structure=== | ||
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===Catalytic activity and functions=== | ===Catalytic activity and functions=== | ||
| − | YMR1 | + | YMR1 in both S. cerevisiae and S. pombe has PI(3)P phosphatase activity <cite>taylor00, blondeau00</cite>. |
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
| + | #Chen pmid=28400531 | ||
#taylor00 pmid=10900271 | #taylor00 pmid=10900271 | ||
#blondeau00 pmid=11001925 | #blondeau00 pmid=11001925 | ||
</biblio> | </biblio> | ||
Latest revision as of 23:50, 13 April 2017
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily YMR1
YMR1 encodes PI(3)P phosphatase found in fungi [1]. It is the single myotubularin in most fungi.
Evolution
YMR1 is found in most fungi [2].
Domain Structure
YMR1 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.
Catalytic activity and functions
YMR1 in both S. cerevisiae and S. pombe has PI(3)P phosphatase activity [1, 3].
References
- Taylor GS, Maehama T, and Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. DOI:10.1073/pnas.160255697 |
- Chen MJ, Dixon JE, and Manning G. Genomics and evolution of protein phosphatases. Sci Signal. 2017 Apr 11;10(474). DOI:10.1126/scisignal.aag1796 |
- Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, and Mandel JL. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. Hum Mol Genet. 2000 Sep 22;9(15):2223-9. DOI:10.1093/oxfordjournals.hmg.a018913 |
