Phosphatase Subfamily YMR1
From PhosphataseWiki
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Myotubularin: Subfamily YMR1
YMR1 encodes PI(3)P phosphatase found in fungi [1]. It is the single myotubularin in most fungi.
Evolution
YMR1 is found in most fungi [2].
Domain Structure
YMR1 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.
Catalytic activity and functions
YMR1 in both S. cerevisiae and S. pombe has PI(3)P phosphatase activity [1, 3].
References
- Taylor GS, Maehama T, and Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. DOI:10.1073/pnas.160255697 |
- Chen MJ, Dixon JE, and Manning G. Genomics and evolution of protein phosphatases. Sci Signal. 2017 Apr 11;10(474). DOI:10.1126/scisignal.aag1796 |
- Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, and Mandel JL. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. Hum Mol Genet. 2000 Sep 22;9(15):2223-9. DOI:10.1093/oxfordjournals.hmg.a018913 |
