Difference between revisions of "Phosphatase Superfamily CC1"

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CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of three families in human:
 
CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of three families in human:
  
- [[Phosphatase_Family_PTP|Classic PTP]] (Protein Tyrosine Phosphatase; generally tyrosine specific)
+
- [[Phosphatase_Family_PTP|PTP]] (Protein Tyrosine Phosphatase; generally tyrosine specific)
  
 
- [[Phosphatase_Family_DSP|DSP]] (Dual Specificity Phosphatases; tyr/ser/thr specific)
 
- [[Phosphatase_Family_DSP|DSP]] (Dual Specificity Phosphatases; tyr/ser/thr specific)

Revision as of 16:29, 3 April 2015

Phosphatase classification: Fold CC1: Superfamily CC1

CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of three families in human:

- PTP (Protein Tyrosine Phosphatase; generally tyrosine specific)

- DSP (Dual Specificity Phosphatases; tyr/ser/thr specific)

- PTEN Lipid phosphatases closely related to DSPs.

- Myotubularin (lipid specific).

Fungi, plants and many protists also have the OCA family.

It shares a Cys-based catalytic motif, CX5R with another two superfamilies CC2 and CC3, but it has distinct structure from them.