Difference between revisions of "Phosphatase Superfamily CC1"

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[[Phosphatase classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]
 
[[Phosphatase classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]
  
CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of three families in human:
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CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below:
  
- [[Phosphatase_Family_PTP|PTP]] (Protein Tyrosine Phosphatase; generally tyrosine specific)
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* [[Phosphatase_Family_PTP|PTP]] (Protein Tyrosine Phosphatase)  - generally tyrosine-specific phosphatases.
  
- [[Phosphatase_Family_DSP|DSP]] (Dual Specificity Phosphatases; tyr/ser/thr specific)
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* [[Phosphatase_Family_DSP|DSP]] (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules.
  
- [[Phosphatase_Family_PTEN|PTEN]] Lipid phosphatases closely related to DSPs.
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* [[Phosphatase_Family_PTEN|PTEN]] - phosphoinositide phosphatases.
  
- [[Phosphatase_Family_Myotubularin|Myotubularin]] (lipid specific).
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* [[Phosphatase_Family_Myotubularin|Myotubularin]] - phosphoinositide phosphatases.
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* [[Phosphatase_Family_SAC|SAC]] - phosphoinositide phosphatases.
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* [[Phosphatase_Family_Paladin|Paladin]] - catalytically inactive phosphatase.
  
 
Fungi, plants and many protists also have the [[Phosphatase_Family_OCA|OCA]] family.  
 
Fungi, plants and many protists also have the [[Phosphatase_Family_OCA|OCA]] family.  
  
 
It shares a Cys-based catalytic motif, CX5R with another two superfamilies [[Phosphatase_Superfamily_CC2I| CC2]] and [[Phosphatase_Superfamily_CC3|CC3]], but it has distinct structure from them.
 
It shares a Cys-based catalytic motif, CX5R with another two superfamilies [[Phosphatase_Superfamily_CC2I| CC2]] and [[Phosphatase_Superfamily_CC3|CC3]], but it has distinct structure from them.

Revision as of 20:57, 27 April 2015

Phosphatase classification: Fold CC1: Superfamily CC1

CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below:

  • PTP (Protein Tyrosine Phosphatase) - generally tyrosine-specific phosphatases.
  • DSP (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules.
  • PTEN - phosphoinositide phosphatases.
  • SAC - phosphoinositide phosphatases.
  • Paladin - catalytically inactive phosphatase.

Fungi, plants and many protists also have the OCA family.

It shares a Cys-based catalytic motif, CX5R with another two superfamilies CC2 and CC3, but it has distinct structure from them.