Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
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(→Classification Chart of Protein Phosphatases) |
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|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM]] (PP2C)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM]] (PP2C)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
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| − | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] (Alkaline Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_AP|AP]]|| bgcolor="#ffffff" colspan="1" | | + | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] (Alkaline Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_AP|AP]]|| bgcolor="#ffffff" colspan="1" | pTyr, perhaps pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
|bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_HP|HP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_HP|HP]] (Histidine Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_HP1|HP, branch 1]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_HP|HP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_HP|HP]] (Histidine Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_HP1|HP, branch 1]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
Revision as of 15:49, 5 January 2015
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart of Protein Phosphatases
| Fold | Superfamily | Family | Substrate | Present in human |
|---|---|---|---|---|
| CC1 | CC1 (Cystine-based group 1) | Classic PTP | pTyr | Yes |
| DSP | pTyr, pSer/pThr, small molecule | Yes | ||
| PTEN | lipid | Yes | ||
| Myotubularin | lipid | Yes | ||
| OCA | ? | No | ||
| CC2 | CC2 (Cysteine Based Group 2) | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | ||
| ArsC | Arsenate | No | ||
| CC3 | CC3 (Rhodanese) | CDC25 | pTyr, pThr | Yes |
| HAD | HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | ||
| NagD | pTyr, pSer | Yes | ||
| MTDP | MTDP (MeTallo-Dependent Phosphatases) | PPP | pSer/pThr | Yes |
| PAP (purple acid phosphatase) | ? | Yes | ||
| PPM | PPM (PP2C) | PPM | pSer/pThr | Yes |
| AP | AP (Alkaline Phosphatase) | AP | pTyr, perhaps pSer/pThr | Yes |
| HP | HP (Histidine Phosphatase) | HP, branch 1 | pTyr, pSer/pThr | Yes |
| HP, branch 2 | pTyr | Yes | ||
| PHP | PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | RTR1 | pSer | Yes |
