Phosphatase classification

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Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Classification Chart of Protein Phosphatases

Fold Superfamily Family Substrate Present in human
CC1 CC1 (Cystine-based group 1) Classic PTP pTyr Yes
DSP pTyr, pSer/pThr, small molecule Yes
PTEN lipid Yes
Myotubularin lipid Yes
OCA  ? No
CC2 CC2 (Cysteine Based Group 2) LMWPTP pTyr Yes
SSU72 pSer Yes
ArsC Arsenate No
CC3 CC3 (Rhodanese) CDC25 pTyr, pThr Yes
HAD HAD EYA pTyr Yes
FCP pSer Yes
NagD pTyr, pSer Yes
MTDP MTDP (MeTallo-Dependent Phosphatases) PPP pSer/pThr Yes
PAP (purple acid phosphatase)  ? Yes
PPM/PP2C PPM/PP2C PPM/PP2C pSer/pThr Yes
AP AP (Alkaline Phosphatase) AP pTyr, perhaps pSer/pThr Yes
HP HP (Histidine Phosphatase) HP, branch 1 pTyr, pSer/pThr Yes
HP, branch 2 pTyr Yes
PHP PHP PHP pHis Yes
RTR1 RTR1 RTR1 pSer Yes

Non-protein phosphatases

Other Classification Schemes