View source for Phosphatase Subfamily TIGAR

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HP|Fold HP]]: [[Phosphatase_Superfamily_HP|Superfamily HP]] (histidine phosphatase):  [[Phosphatase_Family_HP1|HP, branch1 family]]: [[Phosphatase_Subfamily_TIGAR|Subfamily TIGAR]]

Vertebrate TIGAR functions as a fructose- 2,6-bisphosphatase, which results in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. TIGAR is also found in some basal eumetazoan, but is absent from nematodes and arthropoda.

=== Evolution ===
TIGAR is also found in some basal [[Phosphatase_Glossary#eumetazoa|eumetazoan]], but is absent from nematodes and arthropoda.

=== Domain ===
TIGAR has a single domain: HP1 phosphatase.

=== Functions ===
TIGAR is fructose- 2,6-bisphosphatase <cite>bensaad06, li09</cite>, the same function with PFKFB1 of [[Phosphatase_Subfamily_PFKFB|PFKFB]]. (PS: functional redundancy?)

===References===
<biblio>
#bensaad06 pmid=16839880
#li09 pmid=19015259
</biblio>