View source for Phosphatase Subfamily DSP11

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP11|Subfamily DSP11]]

DSP11 is a metazoan-specific subfamily. Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing. 

=== Evolution ===
DSP11 subfamily is found through metazoan ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004984/overview unpublished data from gOrtholog]).

=== Domain ===
DSP11 has a single domain: phosphatase domain.

=== Function ===
DSP11 is mainly localized to the cell nucleus. It was originally identified as being associated with RNA or ribonucleoprotein complexes. It is therefore called  phosphatase that interacts with RNA–ribonucleoprotein complex 1 (PIR1). Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing <cite>Sankhala14</cite>. DSP11 prefers to dephosphorylate RNA than phosphoprotein substrates. Its primary function in vivo is supposed to dephosphorylate RNA 5′-ends <cite>Deshpande99</cite>. This is not surprising given that it is close to another ''atypical'' DSP, RNGTT, RNA guanylyltransferase and 5'-phosphatase. Its function was reviewed in introduction of <cite>Sankhala14</cite> in details.

=== References ===
<biblio>
#Deshpande99 pmid=10347225
#Ho99 pmid=10572165
#Lima99 pmid=10589681
#Sankhala14 pmid=21636784
</biblio>