View source for Phosphatase Subfamily DSP14

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]]

DSP14 is a subfamily emerged in eumetazoan and duplicated in vertebrates. Human has four members, DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28. Little is known about their functions.

=== Evolution ===
DSP14 subfamily emerged in eumetazoan and duplicated in vertebrates.

=== Domain ===
DSP14 subfamily has a single phosphatase domain.

=== Function ===
DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation <cite>Zheng13</cite>. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see [http://www.gtexportal.org/home/gene/DUSP14 GTEx]).

DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 <cite>Wu06</cite>. USP18 was widely expressed in different tissues as evidenced by RT-PCR <cite>Wu03</cite>. RNA-seq from [http://www.gtexportal.org/home/gene/DUSP18 GTEx] shows a high expression in testis and pituitary, and a low expression in skeleton.

DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation <cite>Deng14</cite>.

DUSP28 is widely expressed in different tissues according to RNA-seq data from [http://www.gtexportal.org/home/gene/DUSP28 GTEx], but its function is unknown.

=== References ===
<biblio>
#Deng14 pmid=23929653
#Wu03 pmid=12591617
#Wu06 pmid=16720344
#Zheng13 pmid=23229544
</biblio>