View source for Phosphatase Subfamily PTPRC

__NOTOC__

[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]]


PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

===Evolution===
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.

===Domain ===
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.

===Functions===
CD45 modulates immune function <cite>furlan14</cite>. It is selectively expressed on lymphocytes and dephosphorylates and activates the [http://kinase.com/wiki/index.php/Kinase_Family_Src src family] tyrosine kinases lck, fyn and lyn in B and T cells.

===References===
<biblio>
#furlan14 pmid=25128530
</biblio>