View source for Phosphatase Subfamily CDC14

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:  [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_CDC14|Subfamily CDC14]]

CDC14 subfamily consists of cell cycle genes widely found in eukaryotes with the exception of higher plants. 

=== Evolution ===
CDC14 is found in most eukaryotes with the exception of higher plants. Most vertebrates express two paralogs typically designated CDC14A and CDC14B (see [http://resdev.gene.com/gOrtholog/view/cluster/MC0000760/overview unpublished data from gOrtholog]). 

=== Domain ===
CDC14 has two tandem structural equivalent domains linked by an alpha helix. Both domains have a DSP fold and the second domain is catalytic active. CDC14 also has a conserved nuclear export sequence (NES) at C-terminal. . Yeast CDC14 has a nucleolar targeting sequence at C-terminal  (517-551), which functions as a nuclear localization signal (NLS) in vivo and also binds to Kap121p (also known as Pse1p), an essential nuclear import carrier (karyopherin/importin) in yeast, in a Gsp1p-GTP-dependent manner in vitro <cite>Kobayashi15</cite>. The importin is also found in human (IPO5), but human CDC14s has nucleolar targeting sequence at N-terminal instead of C-terminal and it is unclear whether IPO5 binds to this region <cite>Gray03</cite>.

=== Function ===
Unlike the budding yeast enzyme, Cdc14 orthologs of most other species are not required for mitotic exit <cite>Mocciaro10, Bremmer12</cite>. In vertebrates, there are conflicting reports on the functions of the Cdc14 isoforms, but there is evidence for involvement in regulating mitotic entry, centrosome duplication, DNA repair, and cytokinesis <cite>Mocciaro10, Bremmer12</cite>. 

=== References ===
<biblio>
#Bremmer12 pmid=22117071
#Gray03 pmid=12853468
#Mocciaro10 pmid=20720150
</biblio>