View source for Phosphatase Subfamily PP2D1

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM (PP2C)]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PP2D1|Subfamily PP2D1]]

=== Evolution  ===
The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48).

=== Domain ===
The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using [http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi NLS mapper] and [http://www.moseslab.csb.utoronto.ca/NLStradamus/ NLStradamus].

=== Function ===
The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta <cite>Virok</cite>

=== References ===
<biblio>
#Virok pmid=21244100
</biblio>