View source for Phosphatase Subfamily PPM1K

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPM|Fold PPM]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM]]: [[Phosphatase_Family_PPM|Family PPM]]: [[Phosphatase_Subfamily_PPM1K|Subfamily PPM1K]] (PP2Cκ, PP2Cm, BDP)

PPM1K is a mitochondrial phosphatase that regulates the membrane permeability transition pore and is part of the BCKDA complex.

=== Evolution ===
The PPM1K subfamily emerged in [[Phosphatase_Glossary#Holozoa|holozoa]]. It was lost in [[Phosphatase_Glossary#Ecdysozoa|ecdysozoa]] and sponge. PPM1K is most similar to the ER-anchored phosphatase subfamily [[Phosphatase_Subfamily_PPM1L|PPM1L]].

=== Domain ===
The PPM1K subfamily has an N-terminal mitochondria target signal (MTS) and phosphatase domain <cite>Joshi07, Lu07</cite>. The MTS (predicted by MitoProt) and phosphatase domain are conserved throughout the PPM1K subfamily.

=== Functions ===
Human PPM1K is widely expressed in different tissues, most abundant in heart <cite>Lu07, Joshi07</cite> and [http://www.gtexportal.org/home/gene/PPM1K GTEx database]. Human PPM1K is localized to mitochondrial matrix <cite>Lu07</cite>. It regulates mitochondrial membrane permeability transition pore (MPTP) opening, but the underlying molecular mechanism(s) is unclear <cite>Lu07</cite>. It also functions as pSer phosphatase of the branched-chain a-keto acid dehydrogenase complex <cite>Joshi07</cite>. 

=== References ===
<biblio>
#Joshi07 pmid=17336929
#Lu07 pmid=17374715
</biblio>