View source for Phosphatase Subfamily eak

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_eak|Subfamily Eak]]

=== Evolution ===
The eak subfamily is nematode specific. ''C. elegans'' has two members eak-6 and sdf-9 (eak-5).

=== Domain ===
The eak subfamily has a single structural domain: the phosphatase domain of CC1 fold.

=== Function ===
In ''C. elegant'', both members, eak-6 and sdf-9, potentiate AKT-1/PKB signaling. Eak-6 and sdf-9 mutants have similar [http://www.wormbook.org/chapters/www_dauer/dauer.html dauer] formation phenotypes. The function seems independent of phosphatase activity, because sdf-9 is predicted to be catalytically inactive given the replacement of cysteine by serine at the Cx5R motif <cite>Hu06</cite>.

=== References ===
<biblio>
#Hu06 pmid=16839187
</biblio>