Difference between revisions of "Phosphatase Subfamily CDC25"
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=== Domain === | === Domain === | ||
| − | Human CDC25s have an N-terminal regulatory domain | + | Human CDC25s have an N-terminal regulatory domain known as [http://pfam.xfam.org/family/M-inducer_phosp M-phase inducer phosphatase domain] and a C-terminal phosphatase domain with a rhodanese fold. Both human CDC25s show alternative splicing of the regulatory domain. The N-terminal regulatory domain is classified as tetrapod-specific in Pfam, but has clearly conserved homology with CDC25 genes across the metazoa. |
=== Catalytic activity and functions === | === Catalytic activity and functions === | ||
Revision as of 17:43, 22 August 2015
Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25
Evolution
CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in many species, including two in human, and Drosophila and four in C. elegans, all from apparently independent duplications.
Domain
Human CDC25s have an N-terminal regulatory domain known as M-phase inducer phosphatase domain and a C-terminal phosphatase domain with a rhodanese fold. Both human CDC25s show alternative splicing of the regulatory domain. The N-terminal regulatory domain is classified as tetrapod-specific in Pfam, but has clearly conserved homology with CDC25 genes across the metazoa.
Catalytic activity and functions
Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Their structures and functions have been reviewed in detail [1, 2, 3].
References
- Boutros R, Dozier C, and Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol. 2006 Apr;18(2):185-91. DOI:10.1016/j.ceb.2006.02.003 |
- Rudolph J. Cdc25 phosphatases: structure, specificity, and mechanism. Biochemistry. 2007 Mar 27;46(12):3595-604. DOI:10.1021/bi700026j |
- Boutros R, Lobjois V, and Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat Rev Cancer. 2007 Jul;7(7):495-507. DOI:10.1038/nrc2169 |
