Difference between revisions of "Phosphatase Subfamily PPM1Z"
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=== Evolution === | === Evolution === | ||
| − | The PPM1Z subfamily is found in | + | The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to [[Phosphatase_Subfamily_PPM1G|PPM1G]], but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to [[Phosphatase_Subfamily_PPM1A|PPM1A]], and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies. |
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Notice: Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z. | Notice: Monosiga has [http://phosphatome.net/3.0/database/gene/uid/MbreP135 an unclassified phosphatase] that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z. | ||
Revision as of 04:38, 11 November 2016
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1Z
Evolution
The PPM1Z subfamily is found in eumetazoa but lost from vertebrates. Its sequence is most similar to PPM1G, but it lacks the characteristic PPM1G acidic domain inserted into phosphatase domain. It is also similar to PPM1A, and there is some uncertainty as to whether some unicellular homologs belong to each of these subfamilies.
Notice: Monosiga has an unclassified phosphatase that has a N-terminal myristoylation site but the overall sequence similarity does not well support it is PPM1Z.
Domain
The PPM1Z subfamily has a N-terminal myristoylation site and a phosphatase domain. The phosphatase domain is closer to PPM1G than other PPMs in sequence, but it does not have the acidic domain inserted in catalytic domain which is common in PPM1G subfamily.
Functions
The function of PPM1Z is unclear.
