Difference between revisions of "Phosphatase Subfamily TIMM50"
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| − | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_TIMM50|TIMM50]] | |
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TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) <cite>Yamamoto</cite> <cite>Meinecke</cite>. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site. | TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) <cite>Yamamoto</cite> <cite>Meinecke</cite>. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site. | ||
| − | == | + | ===Evolution=== |
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| − | + | ||
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TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human. | TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human. | ||
| − | + | ===Domain Structure=== | |
| − | == Domain | + | |
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== Catalytic activity == | == Catalytic activity == | ||
| − | + | None | |
| − | == | + | ===Related Kinases=== |
| + | 1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 <cite>Raf</cite>, but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper). | ||
| + | ===Curation notes=== | ||
| − | == References == | + | ===References=== |
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<biblio> | <biblio> | ||
#Raf pmid=12620389 | #Raf pmid=12620389 | ||
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</biblio> | </biblio> | ||
| − | + | ===Links=== | |
| − | == Links == | + | |
[http://www.ncbi.nlm.nih.gov/gene/92609 Human TIMM50] from NCBI Gene | [http://www.ncbi.nlm.nih.gov/gene/92609 Human TIMM50] from NCBI Gene | ||
Revision as of 05:31, 29 December 2014
Phosphatase Classification: FCP: TIMM50
TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.
Evolution
TIMM50 is conserved from yeast to human, while Raf is conserved from sponge to human.
Domain Structure
Catalytic activity
None
Related Kinases
1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [3], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).
Curation notes
References
Error fetching PMID 12620389:
Error fetching PMID 12437925:
Error fetching PMID 16763150:
Error fetching PMID 12437925:
Error fetching PMID 16763150:
- Error fetching PMID 12437925:
- Error fetching PMID 16763150:
- Error fetching PMID 12620389:
Links
Human TIMM50 from NCBI Gene
