Difference between revisions of "Phosphatase Subfamily TIMM50"
From PhosphataseWiki
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===Evolution=== | ===Evolution=== | ||
| − | TIMM50 is conserved from yeast | + | TIMM50 is conserved from yeast to human. |
===Domain Structure=== | ===Domain Structure=== | ||
Revision as of 05:32, 29 December 2014
Phosphatase Classification: FCP: TIMM50
TIMM50 (or TIM50) is named after translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [1] [2]. It is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. It lacks the DxDx[T|V] motif at catalytic site.
Evolution
TIMM50 is conserved from yeast to human.
Domain Structure
Catalytic activity
None
Related Kinases
1) Raf. High throughput yeast two-hybrid assay show Raf kinase can interact with TIMM50, as well as FCP1. The paper also guessed Raf is the substrate of TIMM50 [3], but actually TIMM50 lacks the catalytic motif. (Note: Raf also interacts with FCP1 in the paper).
Curation notes
References
Error fetching PMID 12620389:
Error fetching PMID 12437925:
Error fetching PMID 16763150:
Error fetching PMID 12437925:
Error fetching PMID 16763150:
- Error fetching PMID 12437925:
- Error fetching PMID 16763150:
- Error fetching PMID 12620389:
Links
Human TIMM50 from NCBI Gene
