Difference between revisions of "Phosphatase Gene HsapP726"
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| − | TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element. | + | TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element. It is expressed at ~2 RPKM in a wide variety of tissues (GTEx), and is consistently downregulated in a variety of cancers (TCGA). Bisulfite sequencing indicated that it is silenced in cancers by DNA methylation <cite>Liang10</cite>. A 15 kD ORF was detected by peptide antibodies, but no function is known. |
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== References == | == References == | ||
Latest revision as of 17:25, 22 October 2015
TPTEP1 (psiTPTE22) is a pseudogene copy of the tensin phosphatase, TPTE. It is fragment of TPTE, from AA 51-~140. It is expressed under the control of an HERV endogenous retrovirus element. It is expressed at ~2 RPKM in a wide variety of tissues (GTEx), and is consistently downregulated in a variety of cancers (TCGA). Bisulfite sequencing indicated that it is silenced in cancers by DNA methylation [1]. A 15 kD ORF was detected by peptide antibodies, but no function is known.
