Difference between revisions of "Phosphatase Subfamily PP2D1"
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=== Evolution === | === Evolution === | ||
| − | The PP2D1 subfamily is found in | + | The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48). |
=== Domain === | === Domain === | ||
| − | The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using [http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi NLS mapper] and [http://www.moseslab.csb.utoronto.ca/NLStradamus/ NLStradamus]. | + | The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using [http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi NLS mapper] and [http://www.moseslab.csb.utoronto.ca/NLStradamus/ NLStradamus]. [http://www.proteinatlas.org/search/PP2D1 Protein Atlas] reports it to be found in the nucleoplasm and intermediate filaments, by high-throughput antibody staining. |
=== Function === | === Function === | ||
| − | + | The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta <cite>Virok</cite> | |
=== References === | === References === | ||
<biblio> | <biblio> | ||
| + | #Virok pmid=21244100 | ||
</biblio> | </biblio> | ||
Latest revision as of 21:37, 4 March 2017
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PP2D1
Evolution
The PP2D1 subfamily is found in eumetazoans but is frequently lost. It is absent from major model systems including Drosophila, C. elegans and zebrafish. It has a single human member, PP2D1 (C3orf48).
Domain
The PP2D1 subfamily has a single structural domain: the phosphatase domain. It has a predicted nuclear localization signal (NLS) using NLS mapper and NLStradamus. Protein Atlas reports it to be found in the nucleoplasm and intermediate filaments, by high-throughput antibody staining.
Function
The only publications on any member of the subfamily are showing high-throughput interaction between human PP2D2 and the amyloid protein Abeta [1]
