Difference between revisions of "Phosphatase Subfamily PTC7"
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=== Technical notes === | === Technical notes === | ||
Revision as of 21:14, 20 November 2015
Phosphatase Classification: Fold PPM (PP2C): Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PTC7
Contents
Evolution
The PTC7 subfamily is found throughout eukaryotes. It is single copy in most opisthokonts.
Domain Architecture
PTC7 proteins typically consist of a single structural domain: a PPM-fold phosphatase domain. A PLAT domain is found N-terminal of the phosphatase domain in Monosiga, some algae and scattered other organisms, and Monosiga also encodes an uncertain C-terminal LIM domain.
Functions
Yeast Ptc7p, dephosphorylates and activates the mitochondrial hydroxylase Coq7p (Cat5p) and so activates coenzyme Q6 biosynthesis. Ptc7 may reverse the action of the Coq8 kinase (ABC1/YGL119W) (see, e.g. [1]), and in humans, ABC1 kinases ADCK3 and ACDK4 have been implicated in the related coenzyme Q10 biosynthesis [2]. COQ7 is found in most eukaryotes, except plants and excavates [3]. COQ7 in humans is targeted to mitochondria, cleaved to become trapped in these organelles, and then function in the biosynthesis of ubiquinone, a cofactor in the electron transport chain. The uncleaved form of these proteins in the nucleus [4].
Subcellular localization
Human PPTC7 is reported as a mitochondrial protein by multiple datasets summarized in Mitominer, and knockdown in human cells has an effect on mitochondrial respiration [5], though PPTC7 lacks a mitochondrial targeting signal TargetP 1.1.
References
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- Error fetching PMID 24270420:
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Technical notes
Accessory PLAT domain is found in a small number of single cellular eukaryotes
The combination of PLAT and PPM domain is found in sparsely, by BLASTing monosiga PTC7, both full sequence and the region containing PLAT and PPM, against eukaryotes NR dataset. domain (1-400). Below are the organisms and their genes that have the domain combination of PLAT and PPM:
- Algae: Monoraphidium neglectum (KIY99478.1), Micromonas sp. RCC299 (XP_002499745.1), Bathycoccus prasinos (XP_007509274.1)
- Eudicot: Capsella rubella (XP_006283668.1)
- Cryptomonad: Guillardia theta (XP_005819750.1)
- Fungus: Blastocystis hominis (CBK25361.2)
