Difference between revisions of "Phosphatase Subfamily Dullard"
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1. Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 <cite>SantosRosa05</cite>. | 1. Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 <cite>SantosRosa05</cite>. | ||
Revision as of 05:21, 29 December 2014
Phosphatase Classification: FCP:Subfamily Dullard
Dullard, is also known as CTDNEP1 (CTD nuclear envelope phosphatase 1). It participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and the cascade is conserved from yeast to human [1] (in particular, Figure 5B). Dullard, as well as its substrate, phosphatidic acid phosphatase, lipin, is conserved from yeast to human.
Evolution
Dullard is conserved from yeast to human, so is its substrate lipin and the kinases phosphorylating lipin. However, interestingly, the described kinases in yeast and mammals are of different families, though both of them are present in yeast and mammals.
Domain Structure
Substrates and Related Kinases
| Phosphatase | Lipin | Kinase | |
|---|---|---|---|
| Yeast | Nem1-Spo7 complex | Smp2 | Cdc28/Cdk1 |
| Mammals | Dullard (-? complex) | LIPIN | mTOR |
Notes:
1. Cdc28/Cdk1 (in yeast). Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7 [2].
2. mTOR (in mammals). Lipin has multiple phosphorylation sites. Though many kinases may involve in the multisite phosphorylation, mTOR plays an important role [3].
Catalytic activity
Curation notes
References
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- Error fetching PMID 15889145:
- Error fetching PMID 11792863:
Links
Human Dullard from NCBI Gene
