Difference between revisions of "Phosphatase Family PHP"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PHP|PHP Superfamily]]: [[Phosphatase_Famiyl_PHP|PHP Family]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PHP|PHP Superfamily]]: [[Phosphatase_Famiyl_PHP|PHP Family]] | ||
| − | This superfamily has a single family, subfamily and gene PHPT1 in human. It is found throughout eukaryotes, though lost from fungi. In most species, it is a single-copy gene, but four were found in fruit fly | + | This superfamily has a single family, subfamily and gene PHPT1 in human. It is found throughout eukaryotes, though lost from fungi. In most species, it is a single-copy gene, but four were found in fruit fly. |
Revision as of 01:05, 1 May 2014
Phosphatase Classification: PHP Superfamily: PHP Family
This superfamily has a single family, subfamily and gene PHPT1 in human. It is found throughout eukaryotes, though lost from fungi. In most species, it is a single-copy gene, but four were found in fruit fly.
The known substrates are beta subunit of heterotrimeric G proteins [1], the metabolic enzyme adenosine 5’-triphosphate-citrate lyase (ACL) [2], and the Ca2+-activated K+ channel KCa3.1 [3]. These are known or suspected substrates of the nucleoside diphosphate kinases (NDK).
Involved in nervous system
Its role in neuronal cells is particularly interesting. In C. elegans, the ortholog is expressed exclusively in neurons [4]. In human cells, the overexpression of PHPT1 decreases the activity of ACL and reduces the viability of neuronal cells [5].
References
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- Error fetching PMID 12788074:
- Error fetching PMID 18796614:
- Error fetching PMID 12468887:
- Error fetching PMID 19138678:
