Difference between revisions of "Phosphatase Subfamily CDC25"
(→Catalytic activity and functions) |
(→Evolution) |
||
| Line 3: | Line 3: | ||
=== Evolution === | === Evolution === | ||
| − | CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in | + | CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in many species, including two in human, and Drosophila and four in C. elegans, all from apparently independent duplications. |
=== Domain === | === Domain === | ||
Revision as of 17:40, 22 August 2015
Phosphatase Classification: Fold CC3 (Rhondanese): Superfamily CC3 (Rhondanese): Family CDC25: Subfamily CDC25
Evolution
CDC25 subfamily is found in a broad of eukaryotes, but absent from most if not all of plants. It has multiple copies in many species, including two in human, and Drosophila and four in C. elegans, all from apparently independent duplications.
Domain
Human CDC25s have an N-terminal regulatory domain and phosphatase domain, called M-phase inducer phosphatase domain in Pfam. Due to alternative splicing, the isoforms of human CDC25s have different sequences at regulatory domain region. The N-terminal regulatory domain is found in most deuterostomes, but not protostomes.
Catalytic activity and functions
Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Their structures and functions have been reviewed in detail [1, 2, 3].
References
Error fetching PMID 17568790:
Error fetching PMID 17328562:
- Error fetching PMID 16488126:
- Error fetching PMID 17328562:
- Error fetching PMID 17568790:
