Difference between revisions of "Phosphatase Superfamily RTR1"

From PhosphataseWiki
Jump to: navigation, search
 
Line 1: Line 1:
 
__NOTOC__
 
__NOTOC__
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_RTR1|Fold RTR1]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_RTR1|Fold RTR1]]: [[Phosphatase_Superfamily_RTR1|Superfamily RTR1]]
−
 
 
RTR1 is a phosphatase conserved in eukaryotes that regulates the [[CTD_Phosphorylation|phosphorylation states of C-terminal domain (CTD) of RNA polymerase II]].  
 
RTR1 is a phosphatase conserved in eukaryotes that regulates the [[CTD_Phosphorylation|phosphorylation states of C-terminal domain (CTD) of RNA polymerase II]].  
  
 
=== Evolution ===
 
=== Evolution ===
−
RTR1 is found in most eukaryotes. It is absent from the sponge genome, though it is perhaps due to the quality of genome assembly. It is single copy in human, sea urchin, fruit fly, ''C elegans''. However, two copies are found in yeast (RTR1, RTR2).
+
RTR1 is found in most eukaryotes, usually single copy, though duplicated in yeast.
−
 
+
−
=== Domain Structure===
+
−
RTR1 has a conserved phosphatase domain with a unique mechanism of action <cite>Irani</cite>. Yeast RTR1 has a C-terminal region (CTR) that auto-inhibits the catalytic domain <cite>hsu14</cite>. The human homolog, RPAP2, has a longer tail with limited sequence similarity to CTR, and is known to bind RNA pol II subunit Rpb6 and to be involved in pre-mRNA 3'-end formation <cite>Wani</cite>.
+
−
 
+
−
=== Function ===
+
−
Yeast RTR1 dephosphorylates serine-5 of CTD repeats of RNA pol II <cite>Mosley09 kim09</cite>. These findings were challenged by later studies <cite>xiang12</cite>, but more recent study supports its activity towards serine-5 <cite>hsu14</cite> and also the anti-termination tyrosine-1 on CTD repeats <cite>hsu14</cite>.
+
  
−
=== References ===
+
=== Family structure ===
−
<biblio>
+
RTR1 has a single family, also named  [[Phosphatase_Family_RTR1| RTR1]]
−
#Mosley09 pmid=19394294
+
−
#Wani pmid= 25639305
+
−
#Irani pmid=26933063
+
−
#Kim09 pmid=19679665
+
−
#xiang12 pmid=22781759
+
−
#hsu14 pmid=24951832
+
−
</biblio>
+

Latest revision as of 21:04, 17 October 2016

Phosphatase Classification: Fold RTR1: Superfamily RTR1 RTR1 is a phosphatase conserved in eukaryotes that regulates the phosphorylation states of C-terminal domain (CTD) of RNA polymerase II.

Evolution

RTR1 is found in most eukaryotes, usually single copy, though duplicated in yeast.

Family structure

RTR1 has a single family, also named RTR1

Retrieved from "http://phosphatome.net/wiki/index.php?title=Phosphatase_Superfamily_RTR1&oldid=3900"